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Author Topic: Clinical Trial for People Who Failed at Previous DAA  (Read 9437 times)

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Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Clinical Trial for People Who Failed at Previous DAA
« on: December 16, 2015, 01:39:45 pm »
A few people on the forums have reported that they relapsed, or never reached SVR12, after taking Sovaldi, Harvoni or Viekira.

Here is a clinical trial that would be relevant to that situation. The trial is currently recruiting. There are study locations all over US, plus Canada, UK, Australia, NZ, France. It seems to be for all genotypes:

https://clinicaltrials.gov/ct2/show/study/NCT02607735

The trial is: "Safety and Efficacy of Sofosbuvir/Velpatasvir/GS-9857 in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy (POLARIS-1)"

kim
« Last Edit: December 16, 2015, 02:07:45 pm by KimInTheForest »
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #1 on: December 16, 2015, 02:24:33 pm »
That is the trial my specialist was going to sign me up for if the AbbVie treatment didn't work.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #2 on: December 16, 2015, 03:38:22 pm »
It's all so promising right now. If people don't get cured one way, they'll get cured another.

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #3 on: December 17, 2015, 08:29:30 pm »
Ooh That's the trial my Prof was telling me about too Phily if I relapse. I see it's at RBH Brisbane too. I've been on a clinical trial there before. Trouble being that there's a placebo arm...........Cal :'(
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline hepctreatnow

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  • Posts: 46
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #4 on: January 29, 2016, 07:38:31 pm »
Hi Everyone,

New treatment: Sofosbuvir, Velpatasvir, GS-9857. 1 pill a day with food. This will be the one for all genotypes that will hit the market later this year or early next year.
Its been 10 days and no side effects whatsoever. Vieira Pak + Ribavirin treatment failed 12 weeks EOT.
Contracted 1980's - blood transfusion
Relapse on first treatment - Viekira Pak + Ribavirin
Fibr. Stage F4 Severe Fibrosis
Fibroscan score 28 kpa
Genotype 4 - VL 233,000 at beginning of treatment
Current Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial
Start: 01/19/16
12 weeks treatment

Offline gnatcatcher

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Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #5 on: January 29, 2016, 08:18:19 pm »
very good to hear -- thanks, hepctreatnow.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #6 on: January 30, 2016, 07:15:18 pm »
00
« Last Edit: January 31, 2016, 03:54:18 am by HHburme »
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline hepctreatnow

  • Member
  • Posts: 46
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #7 on: January 30, 2016, 07:19:53 pm »
Hi HHBurme,

Nice to know. I'm in the Deferred Treatment Subsidy group. So far so good. How are you doing?
Contracted 1980's - blood transfusion
Relapse on first treatment - Viekira Pak + Ribavirin
Fibr. Stage F4 Severe Fibrosis
Fibroscan score 28 kpa
Genotype 4 - VL 233,000 at beginning of treatment
Current Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial
Start: 01/19/16
12 weeks treatment

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #8 on: January 30, 2016, 07:31:43 pm »
00
« Last Edit: January 31, 2016, 03:53:54 am by HHburme »
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline hepctreatnow

  • Member
  • Posts: 46
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #9 on: January 30, 2016, 07:38:07 pm »
If you don't mind asking, how's your liver are an F0-1-2-3-4? I'm an F4 compensated but am physically in great shape and my liver improved from my last failed treatment. I will share results as they are made available. This treatment surely is a breeze compare to taking Ribavirin.
Contracted 1980's - blood transfusion
Relapse on first treatment - Viekira Pak + Ribavirin
Fibr. Stage F4 Severe Fibrosis
Fibroscan score 28 kpa
Genotype 4 - VL 233,000 at beginning of treatment
Current Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial
Start: 01/19/16
12 weeks treatment

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: Clinical Trial for People Who Failed at Previous DAA
« Reply #10 on: January 30, 2016, 07:59:13 pm »
00
« Last Edit: January 31, 2016, 03:53:07 am by HHburme »
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

 


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