AS HARVONI STARTS DESTROYING THE THE VIRUS,DOES YOUR WBC CONTINUE THE ATTACK

[The Terminator]

srry about the caps ,was thinking as the harvoni works doing its thing on the virus,does that help your white blood cells,to keep attacking the virus also,anyone have a comment

[gnatcatcher]

Harvoni doesn't depend on your immune system (white blood cells, etc.) to get rid of HCV. The older treatments DID need your immune system's help. Having said that, my WBC before treatment was 5.1, and after 28 Harvoni pills it was 5.7. (Both were within the normal range, which was 4.4-11.3 at that lab.) I wonder if that means the WBCells knew something was going on and therefore mobilized somewhat.

[Lynn K]

Hi Terminator

http://www.infohep.org/Hepatitis-C-treatment-factsheet-iHarvonii-sofosbuvir-ledipasvir/page/2942285/

"How does Harvoni work?"

"Harvoni contains two direct-acting antiviral drugs that target different steps of the hepatitis C virus (HCV) lifecycle. Sofosbuvir is a nucleotide analogue HCV polymerase inhibitor, meaning it blocks the polymerase enzyme which the virus must use to reproduce. Ledipasvir is an HCV NS5A replication complex inhibitor that interferes with another protein HCV uses to reproduce."

Or in other words Harvoni does not destroy the virus it prevents the virus from making copies of itself so as the virus cells age they die off without reproducing.

Not sure about those minor changes in WBC that Gnatty experienced as they were all in normal range.

I had numerous CBC done during my treatment because I was on Ribavirin results as follows:
before tx: 4.8,
On tx in order : (week 4)4.6, (week 8)4.7, (week 10)4.8, (week 11)6.8, (week 12)5.1, (week 13)4.1, (week 14)3.7, (week 15)4.6, (week 17)5.4, (week 24)4.4
Post tx: (SVR12)4.5

I think those couple of higher tests I had a cold with a cough for a couple of weeks during treatment. But otherwise my tests were all in a narrow range up and down and pretty close to my pre and post tx tests. And actually until week 11 when I was sick they were lower than my pre treatment WBC test.

I am not thinking that our immune system response has much to do with the mechanism of action of Harvoni.

If our immune systems could beat hep c we never would have been chronically infected.

So that's my 2 cents anyway
Lynn

[The Terminator]

thanks for both replies makes sense,27pills to go

[The Terminator]

well my friends doc just called with 4week viral load no virus detected,21 pills to go then 8week vl,viral load at start of first pill 200,000 as of now no virus detected nxt will be eot 1/19/2016,then the 12week wait for final result,4/19/2016 for svr,still no side effects,all blood work is perfect,hang in there everyone,and thanks to you all-
The Terminator 

[gnatcatcher]

wonderful to hear! Happy New Year!

[The Terminator]

yes great way to start anew