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Author Topic: AS HARVONI STARTS DESTROYING THE THE VIRUS,DOES YOUR WBC CONTINUE THE ATTACK  (Read 5884 times)

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Offline The Terminator

  • Member
  • Posts: 21
srry about the caps ,was thinking as the harvoni works doing its thing on the virus,does that help your white blood cells,to keep attacking the virus also,anyone have a comment

Offline gnatcatcher

  • Member
  • Posts: 1,372
Harvoni doesn't depend on your immune system (white blood cells, etc.) to get rid of HCV. The older treatments DID need your immune system's help. Having said that, my WBC before treatment was 5.1, and after 28 Harvoni pills it was 5.7. (Both were within the normal range, which was 4.4-11.3 at that lab.) I wonder if that means the WBCells knew something was going on and therefore mobilized somewhat.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,461
  • Get tested, get treated, get cured, fight Hep c!
Hi Terminator

http://www.infohep.org/Hepatitis-C-treatment-factsheet-iHarvonii-sofosbuvir-ledipasvir/page/2942285/

"How does Harvoni work?"

"Harvoni contains two direct-acting antiviral drugs that target different steps of the hepatitis C virus (HCV) lifecycle. Sofosbuvir is a nucleotide analogue HCV polymerase inhibitor, meaning it blocks the polymerase enzyme which the virus must use to reproduce. Ledipasvir is an HCV NS5A replication complex inhibitor that interferes with another protein HCV uses to reproduce."

Or in other words Harvoni does not destroy the virus it prevents the virus from making copies of itself so as the virus cells age they die off without reproducing.

Not sure about those minor changes in WBC that Gnatty experienced as they were all in normal range.

I had numerous CBC done during my treatment because I was on Ribavirin results as follows:
before tx: 4.8,
On tx in order : (week 4)4.6, (week 8)4.7, (week 10)4.8, (week 11)6.8, (week 12)5.1, (week 13)4.1, (week 14)3.7, (week 15)4.6, (week 17)5.4, (week 24)4.4
Post tx: (SVR12)4.5

I think those couple of higher tests I had a cold with a cough for a couple of weeks during treatment. But otherwise my tests were all in a narrow range up and down and pretty close to my pre and post tx tests. And actually until week 11 when I was sick they were lower than my pre treatment WBC test.

I am not thinking that our immune system response has much to do with the mechanism of action of Harvoni.

If our immune systems could beat hep c we never would have been chronically infected.

So that's my 2 cents anyway
Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline The Terminator

  • Member
  • Posts: 21
thanks for both replies makes sense,27pills to go

Offline The Terminator

  • Member
  • Posts: 21
well my friends doc just called with 4week viral load no virus detected,21 pills to go then 8week vl,viral load at start of first pill 200,000 as of now no virus detected nxt will be eot 1/19/2016,then the 12week wait for final result,4/19/2016 for svr,still no side effects,all blood work is perfect,hang in there everyone,and thanks to you all-
The Terminator 

Offline gnatcatcher

  • Member
  • Posts: 1,372
wonderful to hear! Happy New Year!
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline The Terminator

  • Member
  • Posts: 21
yes great way to start anew

 


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