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Author Topic: Liver improvement after cure?  (Read 26486 times)

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Offline Bucky

  • Member
  • Posts: 341
Liver improvement after cure?
« on: February 29, 2016, 04:36:37 pm »
Well, it has been a long time for me since I started treatment (6/6/14) with S&O and was declared cured. I have been having USs every six months for cancer screening, to monitor my cirrhosis and portal hypertension. About a year ago my hepatologist started me on 20mg of Corgard because I have a small abdominal varices.
I had my last US last week and the finding have kind of left me in shock.
The tech was looking at my liver and stated "well it looks like you have a fairly normal looking liver"! I sat up and told her I wanted to look at the monitor since in my 20 years of getting these I pretty well know what a crusty old liver looks like. The scan showed a fairly smooth liver and the kicker was that I now have normal blood flow in my liver. She switched to the Doppler and I could hear the smooth flow of blood and the image of the portal vein showed only blue, not blue then red as in the past.
I received the report today and these were the findings:
"Evaluation of the liver doesn't demonstrate evidence of intraheptic or extraheptic biliary dilation. Common bile duct measures 3.5mm. There is normal hepatopedal flow in the portal vein."
I see my doctor next week but I can only believe that I have maybe turned the corner and my liver is really healing.
My liver is normal size but my spleen is still enlarged and  my gallstone is still growing but only a little.
Bucky
 
« Last Edit: February 29, 2016, 11:38:44 pm by Bucky »
I HAVE SLAYED THE DRAGON.....CURED SVR24!

Offline Mugwump

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  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
Re: Liver improvement after cure?
« Reply #1 on: February 29, 2016, 04:44:06 pm »
Thanks for posting that. I am hoping beyond hope to see something less than a Texas sized cheeseburger with warts and the Rio Grand in flood with spilt taco sauce on my next reports. FANTASTIC news!
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Re: Liver improvement after cure?
« Reply #2 on: February 29, 2016, 05:36:25 pm »
Hi Bucky,

Great news about your liver improvement! Thanks for letting us know, it certainly gives me, and no doubt others, encouragement for the future.  :)
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Liver improvement after cure?
« Reply #3 on: February 29, 2016, 08:06:50 pm »
Hey Bucky,

Great news.  You are not alone, however, considering the severity of your cirrhosis...let me understate by saying, small miracle.  I had a sort of unbelievable one myself...I have wondered about one of my scans being off.  Many folks have reported reversals and indeed many studies show this is happening.  I'm taking a wait and see approach, but I think it is the real deal.  Liver tissue is truly amaising.  So happy for you. 
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Liver improvement after cure?
« Reply #4 on: February 29, 2016, 10:25:22 pm »
That is fantastic hopeful news Bucky!

I had my annual upper endoscopy last Friday. I had grade 3 varicies that required banding back in 2011-2012 had 4 sessions over 4 months time to get them all. That is why I have annual ones now.

Anyway my prior EGD's said I had portal hypertensive gastropathy or Gastric antral vascular ectasia (GAVE) sometimes called watermelon stomach because of the apperance of the stomach lining due to liver cirrhosis but on this EGD there was no mention just normal appearing fundus. So yay!

I am taking this as a good sign but still need to ask my doctor about the full report.

Having my abdominal ultrasound in a few weeks hope mine looks improved also. My flow was always in the right direction but I do have an enlarged spleen. So maybe.......

Best to all
Lynn
« Last Edit: February 29, 2016, 10:30:09 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bucky

  • Member
  • Posts: 341
Re: Liver improvement after cure?
« Reply #5 on: February 29, 2016, 11:45:02 pm »
Thanks everyone! I can't hardly wait until next week to see what my platelet count is along with the rest of my blood work.
Bucky
I HAVE SLAYED THE DRAGON.....CURED SVR24!

Offline Bucky

  • Member
  • Posts: 341
Re: Liver improvement after cure?
« Reply #6 on: February 29, 2016, 11:52:22 pm »
Hey Bucky,

Great news.  You are not alone, however, considering the severity of your cirrhosis...let me understate by saying, small miracle.  I had a sort of unbelievable one myself...I have wondered about one of my scans being off.  Many folks have reported reversals and indeed many studies show this is happening.  I'm taking a wait and see approach, but I think it is the real deal.  Liver tissue is truly amaising.  So happy for you.
Beto
The fear that something was wrong with the scan was why I asked to look at the US image. The tech was impressed that I could read it as well as she could and I told her that I had "On the job training" with my many years of having USs.
Bucky
I HAVE SLAYED THE DRAGON.....CURED SVR24!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Liver improvement after cure?
« Reply #7 on: March 01, 2016, 10:11:24 am »
How fantastic.  Great job Bucky.  I will likely get a scan sometime after my 24 week SVR.  I hope to hear more stories of liver improvement.   
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Flaco

  • Member
  • Posts: 56
Re: Liver improvement after cure?
« Reply #8 on: March 04, 2016, 09:34:33 pm »
Outstanding! I am very happy for you and this is encouraging news.
Best Regards,
Jack

Diag 2001
Failed PEG-int/Riba 2002, 48 wks.
2015-16:
F4 compensated
VL 14.7 million
GT 1A
Alkaline Phosphatase(37-127 U/L): 12/23/15 216; 1/14/16 152; 1/29/16 103; 3/18/16 68; 4/1/16 70
SGPT (ALT) (15-78 U/L) 12/23/15 862; 1/15/16 753; 1/29/16 518; 3/18/16 48; 4/1/16 28
SGOT (AST) (9-44 U/L) 12/23/15 283; 1/15/16 226; 1/29/16 165; 3/18/16 24; 4/1/16 19
Start Harv 24 wks. 3/4/16
Undetected 2 weeks into Tx
Liver&metabolic nos. steadily improving since start TX
EOT 8/18/16

Offline CureSeeker

  • Member
  • Posts: 121
  • Virus Free! Happy Dance Time!
Re: Liver improvement after cure?
« Reply #9 on: March 06, 2016, 02:51:12 pm »
Amazing!  Here's to the researchers who have things moving so quickly and effectively.  Praying for their continued success. 

Congratulations Bucky!  Keep up the good heals!
Once you eliminate the impossible, whatever remains, no matter how improbable, must be the truth.

~ Arthur Conan Doyle


Genotype 3a, F 0-1
Sovaldi & Ribavirin x 24 weeks

2/23/16 - UNDETECTED!  SVR12 achieved.  :D
6/21/17 - UNDETECTED!  1.5 years post treatment.
July 2018 - UNDETECTED!

Offline Mugwump

  • Member
  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
Re: Liver improvement after cure?
« Reply #10 on: March 06, 2016, 03:24:33 pm »
Well after having a fibroscan confirmed at 26kpg just one month prior to 24 weeks of treatment in 2014-'15 which was eot in may 2015. For the first time I am starting to hike and build up a full body sweat and hold my urine for more than 4 hours while I work or exercise. AND not have my urine smell and look like it came out a camel that just crossed the Nafud desert!

So I will take this as meaning my much abused Texas sized hunk of pork which passes as a liver is starting to get the message!

All the best to everyone on this road we travel.

Cheers
Eric
« Last Edit: March 06, 2016, 04:50:42 pm by Mugwump »
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Liver improvement after cure?
« Reply #11 on: March 06, 2016, 03:36:24 pm »
Ah Eric. Ever the poet! lol
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Bucky

  • Member
  • Posts: 341
Re: Liver improvement after cure?
« Reply #12 on: March 09, 2016, 10:42:58 am »
I went yesterday for my yearly follow up and my doctor was very much excited by my US results. She said that the return to normal flow of blood in my liver was a very big deal and an clinical indication of an improving/healing liver. She also said that she has a large number of cured patients receiving great news similar to mine.
All my blood work is perfect except for my platelets with are still not normal, but up by 20,000 from 70,000 to 90,000. It is hard to get an accurate count with my enlarged spleen distorting the size of them, but my PT & INR was within normal range.
My AST 28, ALT 18 and my Bili was 1.0.

Bucky
 
I HAVE SLAYED THE DRAGON.....CURED SVR24!

Offline AllShookUp

  • Member
  • Posts: 30
  • "itching like a man on a fuzzy tree" - Not anymore
Re: Liver improvement after cure?
« Reply #13 on: March 09, 2016, 04:26:13 pm »
That is tremendous news.
Thank you for sharing.
Gives hope to us wannabe better livers.
Male - BabyBoomer
1995 - diagnosed HCV
2002 - Peg + Riba - quit after 5 weeks severe anemia
2015 Nov -start 12 weeks Harvoni +Riba + Procrit
Gen 1b - VL 1,500,000 -ALT93-AST143
Comp cirrhosis - enlarged spleen - platelets 35
Week 5 of Tx - HCV undetected - ALT/AST normal
End Week 12 of Tx - HCV UD - ALT/AST normal
Jan. 25, 2016 EOT
April 4, 2016 - SVR10 UD - ALT/AST normal
May 5, 2016 - SVR14 UD - ALT/AST normal
Aug 5, 2016 - SVR28 UD - ALT/AST normal

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Liver improvement after cure?
« Reply #14 on: March 09, 2016, 07:41:43 pm »
Love, love, love these great success stories!!! I think 2016 and 2017 are going to be banner years in the field of hepatology! FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline AussieRosa

  • Member
  • Posts: 226
Re: Liver improvement after cure?
« Reply #15 on: March 14, 2016, 01:07:11 am »
Bucky, this is truly awesome news. I'm so pleased for you. Couldn't be a better outcome. Congratulations!
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline Flaco

  • Member
  • Posts: 56
Re: Liver improvement after cure?
« Reply #16 on: March 14, 2016, 09:59:08 am »
I had my annual upper endoscopy last Friday. I had grade 3 varicies that required banding back in 2011-2012 had 4 sessions over 4 months time to get them all. That is why I have annual ones now.

Anyway my prior EGD's said I had portal hypertensive gastropathy or Gastric antral vascular ectasia (GAVE) sometimes called watermelon stomach because of the apperance of the stomach lining due to liver cirrhosis but on this EGD there was no mention just normal appearing fundus. So yay!

I am taking this as a good sign but still need to ask my doctor about the full report.

Having my abdominal ultrasound in a few weeks hope mine looks improved also. My flow was always in the right direction but I do have an enlarged spleen. So maybe.......
Sounds good, Lynn!  8)
Hoping for the best. It's high time things started going your way.  :D
Best Regards,
Jack

Diag 2001
Failed PEG-int/Riba 2002, 48 wks.
2015-16:
F4 compensated
VL 14.7 million
GT 1A
Alkaline Phosphatase(37-127 U/L): 12/23/15 216; 1/14/16 152; 1/29/16 103; 3/18/16 68; 4/1/16 70
SGPT (ALT) (15-78 U/L) 12/23/15 862; 1/15/16 753; 1/29/16 518; 3/18/16 48; 4/1/16 28
SGOT (AST) (9-44 U/L) 12/23/15 283; 1/15/16 226; 1/29/16 165; 3/18/16 24; 4/1/16 19
Start Harv 24 wks. 3/4/16
Undetected 2 weeks into Tx
Liver&metabolic nos. steadily improving since start TX
EOT 8/18/16

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Liver improvement after cure?
« Reply #17 on: March 14, 2016, 07:12:06 pm »
More good news!

Just got my Lab work back except for viral load.

ALT 24 & AST 22 both lower than last July ALT 29 & AST 27

Platelet count up to a whopping 111 was 92 in July

Woo whooo!!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Liver improvement after cure?
« Reply #18 on: March 14, 2016, 07:37:53 pm »
Lynn, I'm happy dancing for you --- fantastic news!!!!!  Onward and upward! FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Liver improvement after cure?
« Reply #19 on: March 14, 2016, 07:41:12 pm »
Slowly but surely and don't call me Shirley!  :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Liver improvement after cure?
« Reply #20 on: March 14, 2016, 10:18:00 pm »
Fantastic, Lynn!!!  You are healing and that's a fact!  ;D 8) ;D
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Liver improvement after cure?
« Reply #21 on: March 14, 2016, 11:29:47 pm »
Lynn I knew your labs would rock...
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline coastal girl

  • Member
  • Posts: 36
Re: Liver improvement after cure?
« Reply #22 on: March 15, 2016, 12:35:51 am »
Lynn,  So happy to hear of your positive test results.  Post like this keep hope alive!
8/6/15
1a, shear wave elastography F4
ast-114 alt-80,
viral load 5,941,282

Start Harvoni 9/3/15
ast-131 ast-97, viral load 12,997,415

9/29/15 4 week labs VL 64
ast 34 alt 17
11/25/15  12 wk EOT Undetected!
AST 29 ALT 17  Albumin 3.8 Bil .06

12 week PostTX UNDETECTED!!!
AST 33 ALT 20  Bil. 0.9 Albumin 3.9

25 week Post Tx  UNDETECTED

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Liver improvement after cure?
« Reply #23 on: March 15, 2016, 03:54:44 am »
Look at your platelets! Wow!
What's your INR like?
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Liver improvement after cure?
« Reply #24 on: March 15, 2016, 04:08:12 am »
INR steady at 1.1 same as before treatment. The oldest I have record for is August 2013.

Apparently my INR is the only score I have that raises my MELD to 7

BILIRUBIN 0.5 mg/dL
CREATININE 0.89 mg/dL

My AFP is now 10.8 ng/mL still above max normal of 8.3 ng/mL but before I treated it was 26.6 ng/mL in August 2013 so even more good signs
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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  • Member
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  • It only looks like I know what I'm doing
Re: Liver improvement after cure?
« Reply #25 on: March 15, 2016, 04:26:15 am »
Nice! Your INR kicks my INR's butt! (1.4 I think).

My APF is 8, but before treatment it was nearly 80 so I'm pretty happy about that. Alb, creat and Bili all normal (well bili 1 point above normal but nearly!)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline jakas

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  • Posts: 265
Re: Liver improvement after cure?
« Reply #26 on: March 15, 2016, 05:20:00 am »
My INR is 1 now and 1 before treatment what does it mean ?
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #27 on: March 15, 2016, 05:26:03 am »
Has to do with how long it takes your blood to clot 1 is good higher numbers means it takes longer for your blood to clot.

Cirrhosis effects this number which is why those with cirrhosis bruise easily. Also low platelets which is tied up in all this.

How are your platelet counts?
« Last Edit: March 15, 2016, 05:28:05 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bucky

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Re: Liver improvement after cure?
« Reply #28 on: March 16, 2016, 07:10:16 pm »
More good news!

Just got my Lab work back except for viral load.

ALT 24 & AST 22 both lower than last July ALT 29 & AST 27

Platelet count up to a whopping 111 was 92 in July

Woo whooo!!

I am so happy for you my Little Flying Squirrel!
Bucky
I HAVE SLAYED THE DRAGON.....CURED SVR24!

Offline jakas

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Re: Liver improvement after cure?
« Reply #29 on: March 17, 2016, 05:34:38 am »
My platelet count was 159 the last time they took it which was 2 months before tx.
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #30 on: March 17, 2016, 05:53:39 am »
Wow you are fortunate yours are in normal range. I haven't seen normal for at least 4 years. :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Cute

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Re: Liver improvement after cure?
« Reply #31 on: March 22, 2016, 04:31:50 pm »
More good news!

Just got my Lab work back except for viral load.

ALT 24 & AST 22 both lower than last July ALT 29 & AST 27

Platelet count up to a whopping 111 was 92 in July

Woo whooo!!

My congratulations Lynn! I am so happy for you.

Offline Cute

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Re: Liver improvement after cure?
« Reply #32 on: March 24, 2016, 04:26:01 am »
I found these links compelling.

http://www.medscape.com/viewarticle/839337

http://www.aidsmap.com/Liver-fibrosis-improves-after-successful-treatment-for-hepatitis-C/page/3015981/   

Moreover, we know how is important platelet level after Hepatitis C treatment. Doctors consider the platelet level as sign of successful treatment of Hepatitis C and healing of the liver.

Study given below indicates that growing platelet level after liver surgery may point out regeneration of the liver.  I am not a doctor, but I think it isn't barrier for using my logic.
Logic says if growing platelet level after liver surgery is a indicator of regeneration of the liver, then growing platelet level after Hep C treatment may be considered as a sign of the reverse of the liver fibrosis. The same principle should work here. So, please watch your platelet level. Longer your platelet is in the normal range, stronger is your liver!!!   

http://hepatitiscnewdrugs.blogspot.com/2015/11/platelets-promote-livers-regeneration.html
« Last Edit: March 24, 2016, 04:41:35 am by Cute »

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #33 on: March 29, 2016, 03:00:31 am »
Just got my ultrasound results folks

Liver is now normal size of 16.7 cm was 19.1 cm October 22 2015. Spleen is also decreased in size compared with October study and is now also normal size.

Also previous reports had said a small amount of ascities. The report said "There is no free fluid"

The tech came back to ask me for the doctor if I had done anything since October like lose weight so I was thinking they saw something. I said only thing I had done was cure my hep c

Wow just WOW!!!
« Last Edit: March 29, 2016, 03:02:53 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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Re: Liver improvement after cure?
« Reply #34 on: March 29, 2016, 03:03:04 am »
Amazing news Lynn!
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Cute

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Re: Liver improvement after cure?
« Reply #35 on: March 29, 2016, 04:47:48 am »
Just got my ultrasound results folks

Liver is now normal size of 16.7 cm was 19.1 cm October 22 2015. Spleen is also decreased in size compared with October study and is now also normal size.

Also previous reports had said a small amount of ascities. The report said "There is no free fluid"

The tech came back to ask me for the doctor if I had done anything since October like lose weight so I was thinking they saw something. I said only thing I had done was cure my hep c

Wow just WOW!!!

My Congratulations!!!  :) :) :) Very good news. I am so glad for You!!!
Lynn, previous report said a small amount of ascities. What was the maximum amount ascities ever?


Offline Lynn K

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Re: Liver improvement after cure?
« Reply #36 on: March 29, 2016, 04:55:33 am »
Yes every report for the last several years said some ascities or scant ascities or similar. But never more than that. So the remark no free fluid seems to me to be kind of significant.

This test was done about 46 weeks after finishing treatment and 15 months since my first not detected result after 4 weeks of Harvoni. Basically my liver has not been under attack from hep c since December 2014.
« Last Edit: March 29, 2016, 02:25:58 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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Re: Liver improvement after cure?
« Reply #37 on: March 29, 2016, 05:48:14 am »
Since Dec 2015 or Dec 2014?
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #38 on: March 29, 2016, 02:27:46 pm »
Oops tiny keyboard challenged or math I am not saying which LOL.

Yes 2014 I edited the year in my post
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline KimInTheForest

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Re: Liver improvement after cure?
« Reply #39 on: March 29, 2016, 04:20:40 pm »
Just got my ultrasound results folks. Liver is now normal size of 16.7 cm was 19.1 cm October 22 2015. Spleen is also decreased in size compared with October study and is now also normal size. Also previous reports had said a small amount of ascities. The report said "There is no free fluid"

Wow just WOW!!!

Amazing Lynn. Such good news! Congrats. :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline beto

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Re: Liver improvement after cure?
« Reply #40 on: March 30, 2016, 09:54:40 am »
Amazing our livers...so happy for you Lynn.  I am eager to to hear more.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline dragonslayerinprogress

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Re: Liver improvement after cure?
« Reply #41 on: April 02, 2016, 05:46:53 am »
I sooo needed to read this tonight. I have been in tears because of fear that kept me from treating 2 years ago when I was still an F-2. To see livers healing and reversing is awesome!
I do have a question....after starting treatment is when I started swelling in ankles, feet, and lower legs. I feel like the hulk breaking out of his clothes. I have wonderful long feet...size 10 that now look like puffed up elephant feet. Pitting edema too. I  have had low albumin levels since last year. 3.0 and range is 3.5 -? Also high alk phosphates 188. Have any of you monitored those and how long did it take to go to normal? Will the swelling go away and it seems neuropathy has now set in. Hands and feet. Again, just cried because I could have avoided. I have 1 week to go. At and as is normal. Bilirubin down from 1.9 to 1.4. Albumin is up to 3.2. Platelets are slow but climbing from the lowest point being 47,000 to now being 60,000. I am just really scared and I want to be around for awhile. Thanks for the inspirational stories.
Geno 2b
dx in 1990, 52 years old
Origin: unsure. Might have been infected at birth
Tx Naive
Pre tx labs 12/7/15
VL 1,315,890 6.119
ALT 188
AST 161
Started tx Solvadi/Ribavirin on 1/19/16
4 weeks undetected
8 weeks undetected
12 weeks undetected
16 weeks undetected
20 weeks undetected
24 weeks...no testing
EOT 4 wks UNDETECTED
ALT 34
AST 42
EOT 8 wks- UNDETECTED
ALT 38
AST 50
Platelets 49

Offline Mugwump

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Re: Liver improvement after cure?
« Reply #42 on: April 02, 2016, 06:14:47 am »
I sooo needed to read this tonight. I have been in tears because of fear that kept me from treating 2 years ago when I was still an F-2. To see livers healing and reversing is awesome!
I do have a question....after starting treatment is when I started swelling in ankles, feet, and lower legs. I feel like the hulk breaking out of his clothes. I have wonderful long feet...size 10 that now look like puffed up elephant feet. Pitting edema too. I  have had low albumin levels since last year. 3.0 and range is 3.5 -? Also high alk phosphates 188. Have any of you monitored those and how long did it take to go to normal? Will the swelling go away and it seems neuropathy has now set in. Hands and feet. Again, just cried because I could have avoided. I have 1 week to go. At and as is normal. Bilirubin down from 1.9 to 1.4. Albumin is up to 3.2. Platelets are slow but climbing from the lowest point being 47,000 to now being 60,000. I am just really scared and I want to be around for awhile. Thanks for the inspirational stories.
For some of us it is a longer process to overcome the effects of cirrhosis. HANG IN THERE.  Prior to treatment in 2103 I had taken myself off the road because of brain fog, I was using a cane to get around and starting to forget where I was going and what I was doing.


I finished TX in May 2015 and today I actually worked a ten hour shift on my feet institutional cooking for the first time in over 7 years!


It was a long tedious road back from the brink. I am 63 and I am now in better shape than I have been in a very long time. I am no longer suffering the slow downward spiral of this curse. Sure I am not a 20 year old buck but at least now the horrors of cirrhosis and the feeling of hopelessness are gone.


Cheers
Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Philadelphia

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Re: Liver improvement after cure?
« Reply #43 on: April 02, 2016, 07:00:14 am »
Dragonslayer inprogress, it takes time. And for some of us we see improvement in some areas but not in others.

My albumin levels were dropping and were below the normal range. I had oedema and ascites and was on a diuretic for that. I stayed on that all through treatment, although as albumin started to pick up I cut it down. Now I'm off it altogether except for  when I am doing a lot of air travel or it's really hot weather and im on my feet  for 12+ hour stretches. Even then I'll just take a little and the stop when things are stable. Mightonly be for a few days.

Now most of my levels are normal except for my INR and platelets. They are still funky. So there's still an issue there somewhere. But things are better than they were and it was all going to hell in a hand basket so any improvement is a cause for celebration.

It took a long time to get sick, I figure it'll take a long time to get better. One day at a time.

CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #44 on: April 02, 2016, 01:38:44 pm »
I also have pitting edema I have been taking a diuretic Spironolactone 50 mg which is a low dose which relieves the lower leg and foot swelling. I tried to stop taking it the last couple of months but couldn't take the swollen feet and eventually my knees also were swelling restricting motion so I went back on the Spironolactone.

Are you taking anything for yours you could talk to your doctor about it for symptom relief

Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline dragonslayerinprogress

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Re: Liver improvement after cure?
« Reply #45 on: April 03, 2016, 01:58:04 am »
Lyn,
I haven't talked to him yet but think I might need to. It really hurts. Also seeing neuropathy in hands and feet. Not sure that can recover but sure hope so. Trying not to get discouraged and beating myself up about the fear but...I am still scared lol. Praying God does a miracle.
Geno 2b
dx in 1990, 52 years old
Origin: unsure. Might have been infected at birth
Tx Naive
Pre tx labs 12/7/15
VL 1,315,890 6.119
ALT 188
AST 161
Started tx Solvadi/Ribavirin on 1/19/16
4 weeks undetected
8 weeks undetected
12 weeks undetected
16 weeks undetected
20 weeks undetected
24 weeks...no testing
EOT 4 wks UNDETECTED
ALT 34
AST 42
EOT 8 wks- UNDETECTED
ALT 38
AST 50
Platelets 49

Offline Lynn K

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Re: Liver improvement after cure?
« Reply #46 on: April 04, 2016, 09:13:12 pm »
Hi All

Had a fibroscan done today and not much change to report.

My Nov 2014 score was 27 and my score from today April 2016 was 33 so actually a bit higher but I believe that is not significant and just statistical variation owing to the variability if the test itself.

Bottom line so far at least my cirrhosis remains unchanged but I am cured so I should not get any worse and may improve with time

Only time will tell.....
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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