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Author Topic: Non-Detectible after 5 weeks on Harvoni!  (Read 13687 times)

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Offline Allen Cunningham

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Non-Detectible after 5 weeks on Harvoni!
« on: March 05, 2016, 04:50:09 pm »
Diagnosed 8/97 with HepC
Liver Transplant 7/2004
Genotype 1b, Biopsy:12/2015: TX Naive, Fibrosis Level 1
v/l: ~600,000 - ~1,000,000 ALT: 26, AST: 26
Started 12 wks Harvoni on 1/19/16

Hi guys, I'm on my 7th week of Harvoni and I tested nondetectable at week 5!
I haven't really had any side effects since I've been on it except for a very pleasant buzz the first week when I took it in the morning.
It is just so liberating to know that I am free of the virus. The psychological effects alone knowing that you no longer have the virus gives you a new joy for life!

I had a liver transplant in 2004, and when I had a biopsy in December 2015 I was at fibrosis level 1, my ACT and AST were normal and my virus level was at about 1 million.
Since I was post transplant I was at the top of the list for Harvoni and I didn't have to pay anything for a $94,000 treatment.

I probably got hepatitis C back in the mid-60s from injection drug usage or when I was in Vietnam as a medic I was around a lot of blood. All I know is I've had the virus in my body for probably 50 years. Even when I was diagnosed in 1997 I really didn't have any severe hep C effects that I knew about. They came later when I needed the transplant

No I post transplant for 11 years I didn't think I noticed any effects of my hepatitis C. I was very blessed because most post-transplant patients have cirrhosis within about  7 years because the virus attacks the new liver.
 but now I feel so much better after only about five weeks. I am hoping they loosen the criteria for others so everyone can get this treatment. I'm coming up on eight weeks of treatment next week and one more bottle of Harvoni and I'll be finished.
Feeling very blessed!

Offline Philadelphia

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #1 on: March 05, 2016, 05:29:46 pm »
Congratulations on your "undetected" results! Great news.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline NYCHEPCMAN

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #2 on: March 05, 2016, 05:34:58 pm »
Way to go! Terrific news!!
GT 1b
VL 1,237,287
Diagnosed November 2015
alt 66 ast 35
F2 fibrosure
2/3/16 Started 12 weeks Viekira
Week 4: Hep C virus by PCR   <1.18 NOT detected, <15 not detected IU/Ml AST 18, ALT  25

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #3 on: March 05, 2016, 06:32:19 pm »
Thanks guys!

Offline dragonslayerinprogress

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #4 on: March 07, 2016, 07:04:27 pm »
I see everyone saying undetected. Why did my dr use Negative instead? Kind of wierd since everyone is saying undetected. Curious minds want to know
Geno 2b
dx in 1990, 52 years old
Origin: unsure. Might have been infected at birth
Tx Naive
Pre tx labs 12/7/15
VL 1,315,890 6.119
ALT 188
AST 161
Started tx Solvadi/Ribavirin on 1/19/16
4 weeks undetected
8 weeks undetected
12 weeks undetected
16 weeks undetected
20 weeks undetected
24 weeks...no testing
EOT 4 wks UNDETECTED
ALT 34
AST 42
EOT 8 wks- UNDETECTED
ALT 38
AST 50
Platelets 49

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #5 on: March 07, 2016, 07:45:47 pm »
It probably means the same thing. My lab report says

 'HCV RNA Not Detected'

Offline FutureThinker

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #6 on: March 08, 2016, 12:26:26 pm »
Allen, TERRIFIC NEWS!!!  ft
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline malou

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #7 on: March 08, 2016, 01:20:18 pm »
Wonderful news Alan, so very happy for you.

I too have been undetected after 4 and now 8 weeks of treatment, and I feel wonderful.  Tons of energy, I have been physically active every day for the first time in many years.

I have 16 pills left, and I expect this thing is gone.  Best of luck to you Alan, hope this all continues.
HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #8 on: March 08, 2016, 01:54:46 pm »
Fantastic! I 'm sure you will be completely cured since you were undetected after 4 weeks!

Harvoni (and the generics) are kickin' ass and taking no virus prisoners!

I am especially happy for all the folks that had to go through tx on  IFN and all the disappointment that stuff brought with all of the false undetectable labs.

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #9 on: March 08, 2016, 07:02:00 pm »
I never had that issue while I was on interferon. My viral load never declined and in fact actually increased while I was taking Interferon and ribavirin.

There were several ways a patient could respond to interferon treatment.

SVR: Interferon TX worked for about 30% of GT 1 patients.

Relapse: Unfortunately many did as you said relapse

Breakthrough: Some were not detected for a time on TX but then the virus became detectable again while still treating

Non responder: The viral decreased but never reached not detected.

Null responder: Viral load unchanged by treatment like me.

Leave it to me to get a tough bug. :)

Harvoni is awesome.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline beto

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  • "no risk it, no biscuit"
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #10 on: March 08, 2016, 07:27:14 pm »
Hey Allen,

Wow.  Nice!  Amazing that you are in such good shape after all you have been through.  A long time to have been coexisting with this crazy disease.  You have been having the "Harvoni High", not everyone gets to experience that.  Love your enthusiasm.  You are a pretty stalwart person. Keep up the good work.  peace
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Allen Cunningham

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  • Posts: 59
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #11 on: March 08, 2016, 08:15:19 pm »
Thank you guys for the encouragement!

Beto - Did you go from Cirrhosis to f0 due to Harvoni healing the scarring?

If so that is really amazing!

Offline beto

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  • "no risk it, no biscuit"
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #12 on: March 08, 2016, 09:08:43 pm »
Allen,

That is what my fibroscans report.  I am suspicious that possibly one of the scans, could have been off or, glitched for some reason.  I like to believe they are correct or close, however, a bit on the extreme side.  I do have the reports.  I thought of not posting because they are a challenge to believe for some.  At least, I have had posts by a few folks who appeared to indicate that could be the case. I guess people could easily come on this site and say anything they like.  Most are anonymous.

I also might "tell my story" for Lucinda and reveal my identity and post the scans.  For now i will just say; yes, if the scans are correct very remarkable.  I am being sincere.  Also, I have seen a few accounts on this forum that indicate scenarios like mine and have found studies to indicate the same.

Lastly, I have to wonder if it is possible that the sound wave of the scan could direct through "other" tissue on occasion.  That perhaps, bodies being different and internal organs in "slightly off" placements...well.  Of couse now I am talking myself out of one of my happiest moments in my life.  I hope they are correct and that millions will reverse damage after treatment.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #13 on: March 08, 2016, 09:51:53 pm »
Just amazing, we live in a wonderful age!

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #14 on: March 09, 2016, 12:42:58 am »
I will be seeing my liver specialist office in April getting my blood work and ultrasound soon.

I was diagnosed with cirrhosis in Jan 2008 by liver biopsy and had a fibroscan score of 27 to confirm cirrhosis for my insurance in Oct 2014. I treated in Mar 14 to Jun 14 relapsed but my liver had 3 months at least off and was not detected again after I treated again in Nov 2014 and have been not detected since so really my liver has been on a long vacation by now.

Getting very curious to see if I have had any improvement being a patient with symptomatic cirrhosis and for the last 2 years except for 4 or 5 months my liver was not being attacked.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline AussieRosa

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  • Posts: 226
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #15 on: March 09, 2016, 01:38:25 am »
Good luck with your treatment, Allen. You've had a hard road to travel. I hope you achieve SVR and full good health.

And good luck with your upcoming tests, Lynn.
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #16 on: March 09, 2016, 02:20:59 am »

It is just so liberating to know that I am free of the virus. The psychological effects alone knowing that you no longer have the virus gives you a new joy for life!

Feeling very blessed!

Congrats Allen!  Love that quote by you above!  8)
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Allen Cunningham

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  • Posts: 59
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #17 on: March 09, 2016, 12:12:43 pm »
Thanks for all the encouragement guys, what a game-changer these meds are!

Platelet count - I have had low platelets since my liver disease before transplant, I used to have to get platelets before any surgery.

After transplant I don't need them for surgery, however my platelets have been marginal, 116 where normal is > 120-400
What about you guys that were low before and now have been cured for a long time, how have platelets responded?

Offline Bree

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  • "Today is a good day for a great day!"
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #18 on: March 09, 2016, 02:59:19 pm »
Hey Allen, I'm about 6 months post and my platelets are still low (about the same as your numbers on that) .  Everything else normal range.  I get tested again this Monday, I'm interested to see if they have come up at all.  I'll let you know... Bree
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #19 on: March 09, 2016, 04:10:24 pm »
Thanks Bree, maybe they slowly come up after the healthy liver gets better at  clotting blood

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #20 on: March 09, 2016, 06:06:35 pm »
I am waiting to see shortly will be having blood tests next week. My platelets have been about 90 with normal for my lab at 150. I haven't had hep c bothering my liver since I started harvoni in Nov 2014 so will be interesting to see if there has been any change. See if my cirrhosis improves at all
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #21 on: March 09, 2016, 06:18:02 pm »
I am waiting to see shortly will be having blood tests next week. My platelets have been about 90 with normal for my lab at 150. I haven't had hep c bothering my liver since I started harvoni in Nov 2014 so will be interesting to see if there has been any change. See if my cirrhosis improves at all

Hey Lynn, I hope yours come up too. Normal at my lab is 150 also.   I just went back and looked and my platelets were 88 on Nov. 9 and 141 on Dec. 21 so they have come up. That's the highest in as long as I can remember.   Low platelets have been a continual thing for me. 

I've been sick lately so hoping my blood work looks good across the board.  Fingers crossed for all of us.  Let us know when you get your results.
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #22 on: March 09, 2016, 06:43:58 pm »
Bree - Platelets of 141 are normal on the labs I get. They are low normal, but they don't get flagged unless they are below 120

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #23 on: March 09, 2016, 06:49:57 pm »
My platelets are down because my spleen to be enlarged and sequestering platelets because of my cirrhosis. Mine were normal prior to being diagnosed with cirrhosis.

In July which was 3 months post treatment and 7 months since I tested not detected on Harvoni my platelets were still 92.

I guess there are several causes for low platelets including hep c infection but for mine to improve it would be a sign my cirrhosis is improving. So we shall see.....
« Last Edit: March 09, 2016, 06:52:38 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Allen Cunningham

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  • Posts: 59
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #24 on: March 09, 2016, 07:59:51 pm »
Diagnosed 8/97 with HepC
Liver Transplant 7/2004
Genotype 1b, Biopsy:12/2015: TX Naive, Fibrosis Level 1
ALT: 26, AST: 26
Started 12 wks Harvoni on 1/19/16
Week 5 undetectible!

Lynn - Do you ever want to get a transplant, or are you coping OK with your liver disease?

For me, it was a huge thing to go through, but I felt so good afterward it was worth it. I remember thinking while I was laying in the hospital a couple of days after surgery, "I haven't felt this good since I was 16 years old".

That was in  2004, and I had to constantly worry about Hepc attacking the graft. One of the nurses there told me "Usually in around 7 years transplant patients will have Cirhossis again", - What a way to spoil the joy!

After almost 12 years all my labs were normal and Biopsies shows only mild inflammation, then I started Harvoni and am now undetectable.


Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #25 on: March 09, 2016, 08:18:09 pm »
Hi Allen,

From what I understand I am not eligible for transplant as I am a child "A" MELD 8 and that you need at least MELD 15 to be listed because they want the risk of dying from liver disease to be greater than dying from the transplant. 

I person I know on another forum who had a transplant commented it is generally better to keep what with you were born with if possible because of the whole process of liver transplant and lifestyle changes you guys have to deal with post like all the anti rejection drugs and the side effects from them.

I have heard as well that Hep c can come roaring back with a vengeance post transplant and even as soon as 5 years without cure of the virus the new liver can have cirrhosis thank goodness for our magic pills

I guess I am coping well enough. I work full time only complications were esophageal varicies that I had banded and a small amount of ascities and some edema. So as long as I remain compensated and don't develop HCC I would not even be eligible anyway. I hope that is not a bridge I ever need to consider to cross.

Huge congrats on getting your transplant and giant huge congrats on being not detected on treatment!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline LeslieR1234

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  • Posts: 4
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #26 on: March 09, 2016, 09:22:13 pm »
Congratulations! I too tested "undetected" after 5 weeks. Im in week 7 too. Let's fight this fight!

Here's to a cure!!!
LeslieR
Genotype 1A
Diagnosed 1985 Hep C
Fibrospect F2-F4
HCV RNA 875,000
Treatment Naive
Started Harvoni 1/27/16
Lab Results on 3/1/16
HCV Viral load, undetected.
ALT just 5 points over range (all labs have been abnormal for the past 25 years)
EOT lab results HCV undetected
ALT and AST slightly elevated .

Offline AussieRosa

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #27 on: March 09, 2016, 10:44:50 pm »
Welcome to the forum, LeslieR! Good luck with your treatment. Please keep us posted on how you're doing.
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline Allen Cunningham

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  • Posts: 59
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #28 on: March 10, 2016, 01:01:18 am »
Lynn -

I had a low MELD also but I had a living donor so they transplanted me immediately.

I take Prograf for anti-rejection and I have had no side effects that ever made me feel bad. Just increased sensitivity to the sun and need to wear sunblock to avoid skin cancers. I have had to have a few frozen off but not the Melanoma type.

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #29 on: March 10, 2016, 02:36:50 am »
My only living relative is my brother in NY. I live in WA. He is 69 years old. And like I said I am a child "A"

Just hoping that rock inside me that was once my liver improves with time. And anyway I am fine as long as I don't get HCC. With being cured I will probably die from something other than liver disease.

The liver transplant procedure itself is not with out risk.

Got this from the Mayo clinic site

"For liver transplants using living donors, the five-year survival rate is about 78 percent. That means that for every 100 people who receive a liver transplant using a living donor, 78 will live for five years and 22 will die within five years."

As a Child "A"  my score says I have a life expectancy 15-20 years so better I dont get a transplant my odds are better without a transplant than with. Which is why a transplant center would not list someone as "healthy" as I am. I am 57 so 15 years is 72 the same age both my parents passed away. My other brother passed away at 68 years old.

So even with cirrhosis I will likely outlive my family.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #30 on: March 10, 2016, 04:41:37 am »
Can your Child-Pugh score improve with time? If your INR/Alb/Bili results improve, and they are partly what determine your Child-Pugh score, can you move from say B to A?
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #31 on: March 10, 2016, 04:50:39 am »
Absolutely people on the transplant move up and down often because of changing test values.

The Child Pugh score was what was used to determine transplant priority but several years ago they started using the MELD score to prioritize patients for severity of liver disease.

Of course anyone without liver disease could be evaluated against either scale. A healthy person would score as Child A and MELD 6 as that is the lowest score possible
« Last Edit: March 10, 2016, 04:52:25 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #32 on: March 10, 2016, 04:55:29 am »
Thanks Lynn, was hoping you'd see the question.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #33 on: March 10, 2016, 04:58:29 am »
Hope I answered your question. You and I are both child A so I assume this is about someone else
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Forest dweller

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #34 on: March 10, 2016, 07:46:29 pm »
I am soooo happy for you!!!!!
How many weeks were you on the Harvoni ???

Offline Allen Cunningham

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Re: Non-Detectible after 5 weeks on Harvoni!
« Reply #35 on: March 10, 2016, 08:11:19 pm »
I am going on week 8 next week. I just had my labs yesterday but haven't gottn the results back yet

 


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