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Author Topic: VL is back 12 weeks after EOT  (Read 9670 times)

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Offline Lusitano

  • Member
  • Posts: 9
VL is back 12 weeks after EOT
« on: March 17, 2016, 04:30:32 pm »
So today I received a call from the local VA infectious disease clinic who treated me with Viekira pak + Ribavirin for 12 weeks. It has been 12 weeks after EOT and labs show return of VL, again... Followed instructions to a tee and never missed a dose. VA following up with some type of resistance testing? Confidence is low at this point... :(
Logged
1982 diag non a-b
2000 Genotype 1A, InterferonA2b/Riba part responder
2013 Biopsy - Mild, F1
2015 Fibroscan score F3
2015 Veikira Pak +Riba x 12 weeks

Pretreat: ALT 83, AST 46, VL 8.3M
Week 2: ALT 36, AST 21
Week 4: VL 19
Week 6: VL <15 (<1.18 log)
Week 8: No virus detected
Week 12: EOT No virus detected
Week 24: Relapse :-(
Week 25: Resistance Testing

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: VL is back 12 weeks after EOT
« Reply #1 on: March 17, 2016, 04:47:12 pm »
So terribly sorry. Even if you didn't take the medication perfectly and missed a few doses, this isn''t your fault. Sadly, some have resistance. So, they will find out what you have and very likely offer you something easier with fewer side effects than Viekira.

Don't freak if your VL and ALT are higher than before for awhile - this is normal and expected.

Also, even though you weren't permanently cured, your liver likely had time to heal a bit and you didn't waste your time.

Keep us posted.
Logged
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Lusitano

  • Member
  • Posts: 9
Re: VL is back 12 weeks after EOT
« Reply #2 on: March 17, 2016, 05:19:59 pm »
Thanks Lucinda. I will post any news.
Logged
1982 diag non a-b
2000 Genotype 1A, InterferonA2b/Riba part responder
2013 Biopsy - Mild, F1
2015 Fibroscan score F3
2015 Veikira Pak +Riba x 12 weeks

Pretreat: ALT 83, AST 46, VL 8.3M
Week 2: ALT 36, AST 21
Week 4: VL 19
Week 6: VL <15 (<1.18 log)
Week 8: No virus detected
Week 12: EOT No virus detected
Week 24: Relapse :-(
Week 25: Resistance Testing

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: VL is back 12 weeks after EOT
« Reply #3 on: March 18, 2016, 01:37:35 am »
So sorry to hear this news. There are new cures coming - stay focused on that if you can.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline jakas

  • Member
  • Posts: 265
Re: VL is back 12 weeks after EOT
« Reply #4 on: March 18, 2016, 05:07:25 am »
So sorry to hear this. I myself have just finished tx so this is very disturbing :(
But keep your chin up, there is a cure, sometimes it happens as planned sometimes not. You will make it soon again.
Logged
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Lusitano

  • Member
  • Posts: 9
Re: VL is back 12 weeks after EOT
« Reply #5 on: March 18, 2016, 03:36:12 pm »
Thank you all for the words of encouragement. Feeling very disappointed but not hopeless. I will continue the fight :-|
Logged
1982 diag non a-b
2000 Genotype 1A, InterferonA2b/Riba part responder
2013 Biopsy - Mild, F1
2015 Fibroscan score F3
2015 Veikira Pak +Riba x 12 weeks

Pretreat: ALT 83, AST 46, VL 8.3M
Week 2: ALT 36, AST 21
Week 4: VL 19
Week 6: VL <15 (<1.18 log)
Week 8: No virus detected
Week 12: EOT No virus detected
Week 24: Relapse :-(
Week 25: Resistance Testing

Offline BillT

  • Member
  • Posts: 573
Re: VL is back 12 weeks after EOT
« Reply #6 on: March 19, 2016, 11:48:53 am »
Keep the faith Lustino.I'm using the VA also and this is one area they're really good with.As Philly said the new meds are coming out and they'll sort you then.I finished my tx in January and have my 12 week bloods coming up on the first and I'm a mess right now.Eventually we're going to bury the dragon for good.It's just going to take some of us longer than others.
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline BillT

  • Member
  • Posts: 573
Re: VL is back 12 weeks after EOT
« Reply #7 on: March 19, 2016, 12:14:27 pm »
While I'm thinking about it and just for the information,I just read a article that said the number of veterans being treated by the VA for HCV is putting a huge dent in their budget.They are willing to spend the money on us and they are willing to do whatever they need to to treat us.Keep us posted on what happens.
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: VL is back 12 weeks after EOT
« Reply #8 on: March 19, 2016, 12:42:16 pm »
Quote from: Lusitano on March 18, 2016, 03:36:12 pm
Thank you all for the words of encouragement. Feeling very disappointed but not hopeless. I will continue the fight :-|

Good luck Lusitano! I can only imagine what a blow this news is. But as others here have said, new drugs and refinements are coming out all the time right now, including drugs for treating relapsers and those who have resistant strains. It's a gold rush for Hep C meds. And everyone will be getting cured one way or another. Keep the faith.

kim
Logged
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/
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