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Author Topic: Daclatasvir and sofosbuvir Tomorrow  (Read 10938 times)

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Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Daclatasvir and sofosbuvir Tomorrow
« on: March 23, 2016, 06:45:59 am »
Greetings all,

I am one of the fortunate few from Australia who has just received my first script of the above mentioned drugs.
And let it be known how eternally grateful I am to be in Australia and allowed access to these drugs at such an affordable price,  something I know many,  many countries are far behind in doing.

I am HIV/HCV 3 and was diagnosed 18 months ago.
Although a newcomer to HCV I have had many side effects to HIV medications and other treatments and am sitting here now excited about saying goodbye to hepatitis but at the same time nervous as all hell about something going wrong.

I would greatly appreciate any words of wisdom and advice.
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #1 on: March 23, 2016, 07:00:22 am »
Drink plenty of water! Get plenty of rest if you need it. Don't forget to take your pills. Stay in touch with others going through treatment - you'll get tips, tricks, sympathy, good advice and be able to share your own knowledge.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #2 on: March 23, 2016, 07:07:50 am »
Thank you yes,  that is excellent advice.
I came here when first diagnosed and found the forum very helpful.
Once again I will be doing the same.
Water,  no problem as I drink litres a day,  sleep has always been an issue but with HIV I have learnt the hard way how absolutely essential compliance is so no problems there.
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #3 on: March 23, 2016, 07:10:32 am »
You will romp it in, then. All your ducks are in a row. All you need to do now is start! :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #4 on: March 23, 2016, 07:13:31 am »
Keep an eye too on David Peiper's blog here - he is in a similar position to you. And aren't we lucky here in Aust to have access to these drugs! So far there have been 3,800 prescriptions written for DAAs in March alone. More than all the treatments Australia-wide fir all of 2015.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #5 on: March 23, 2016, 07:23:14 am »
Thank you I will.
Yes us Australians are very very blessed.
It's not a right and I never expected it to be so am extremely grateful.
Night from Sydney and thank you
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #6 on: March 23, 2016, 01:53:16 pm »
Welcome to the forums, Tomcat, and good luck on your treatment journey! I too was Geno 3, and I was cured with Harvoni+Ribavirin last year. Would have much preferred the combo you will be taking since I would have avoided the ribavirin effects that way. But daclatasvir had not yet been approved when I started treatment.

Enjoy the ride :)
kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #7 on: March 23, 2016, 04:52:04 pm »
Hi Kim,
Thank you so much.
I know these drugs are nothing compared to the old generation and so grateful for that.
Have been taking HIV ARV for almost 20 years now so used to popping my pills on time.
Am so excited as tonight is the night that I start to fight back.
Unfortunately I have had severe side effects to some medication and although I am sure all will go well I am very nervous.
It's like a roller-coaster of excitement versus anxiety.
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #8 on: March 23, 2016, 04:54:24 pm »
There have been a few other forum people on the sofosbuvir/daclatasvir combo so far (since it is fairly new). And from what I have heard, it has pretty much the least side effects of anything so far... I think you'll be fine. :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #9 on: March 23, 2016, 04:57:38 pm »
Yay!
Thanks for that little gem,  you just gave me a happy little boost.
Here's to day 1!
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #10 on: March 24, 2016, 06:50:29 am »
Well it's 10pm in Sydney and the first pills are down and so far so good.
I hope that all my anxiety will pass and my body kindly accepts these amazing drugs.
Feeling very bloated right now with tonight and tomorrow morning being the real test.
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #11 on: March 24, 2016, 07:05:20 am »
All the best. Try to focus on things other than treatment for large chunks of your day or you'll drive yourself crazy. I know this from experience! ;)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Tomcat

  • Member
  • Posts: 73
  • HCV/ HIV on Daklinza and Sofosbuvir
Re: Daclatasvir and sofosbuvir Tomorrow
« Reply #12 on: March 24, 2016, 07:43:54 am »
Thank you.
Watching my favourite movie,  feeling good and ready to enjoy the Easter weekend.
Hope you to are planning on a nice weekend.
HIV/HCV G3 Coinfection diagnosed March 2014
Started Dak/ Sof Treatment March 2016
09/03     AST 147  ALT 261
03/05     AST 21    ALT 24
28/06     AST 21    ALT 19
Viral Load - Undetected

 


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