Welcome, Guest. Please login or register.
May 26, 2024, 11:12:41 am

Login with username, password and session length


Members
  • Total Members: 6309
  • Latest: Vicki
Stats
  • Total Posts: 55126
  • Total Topics: 4851
  • Online Today: 98
  • Online Ever: 1314
  • (June 22, 2016, 05:23:42 am)
Users Online
Users: 0
Guests: 40
Total: 40

Welcome

Welcome to the Hep Forums, a round-the-clock discussion area for people who have Fatty Liver Disease, Hepatitis B, C or a co-infection, their friends and family and others with questions about hepatitis and liver health. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

Privacy Warning: Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.
  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.
  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.
  • Product advertisement (including links); banners; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from the Hep Forum Moderators.
Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Pantoprazole 40 mg and Harvoni  (Read 9955 times)

0 Members and 1 Guest are viewing this topic.

Offline HCV_FIGHTER

  • Member
  • Posts: 9
  • This Too Shall Pass
Pantoprazole 40 mg and Harvoni
« on: April 05, 2016, 03:56:37 am »
Hi Every one,

I have question is there any interaction between "Pantoprazole 40 mg" and Harvoni ?

I'm under treatment for 6 week with "Pantoprazole 40 mg" and soon I'm going to start my harvoni for 12 weeks.

I asked my physician and he not answer me clearly he said no problem ! with no details. :-X


Thank you
Merai
This Too Shall Pass

Offline Coach Mike

  • Member
  • Posts: 292
    • Affordable Hepatitis C Treatment
Re: Pantoprazole 40 mg and Harvoni
« Reply #1 on: April 05, 2016, 01:24:29 pm »
Hi,
Any drug that decreases acidity in the stomach is not a good idea when taking Harvoni, as ledipasvir requires an acidic environment for absorption.  Many people I know who simply can not do without their stomach meds have chosen sofosbuvir/daclatasvir instead.
There is some very detailed information on this topic at FixHepC.com.
CM
Genotype 1a, Biopsy:11/2014: F-1, Tx Naive
Fibrosure, 7/20/15: F-1-2
Pre tx v/l: 1,600,000, ALT: 75, AST: 48
Started generic sofosbuvir & ledipasvir: 10/23/15
4 wk labs: 11/19/15, ALT: 21, AST: 16, V/L:  UND
Started 8 week Harvoni tx: 11/20/15
8 wk labs, 12/15/15, ALT: 15, AST: 13, V/L: UND
4/11/16 12 week EOT-Undetected
7/5/16 SVR 24

Offline HCV_FIGHTER

  • Member
  • Posts: 9
  • This Too Shall Pass
Re: Pantoprazole 40 mg and Harvoni
« Reply #2 on: April 05, 2016, 08:02:29 pm »
Hi Coach Mike,
Thanks a lot for your post I will read that topic at fixhepc.com.

So I shall return back to my doctor prior to start Harvoni to see if I have to stop the "Pantoprazole 40 mg" .


CM
This Too Shall Pass

Offline Coach Mike

  • Member
  • Posts: 292
    • Affordable Hepatitis C Treatment
Re: Pantoprazole 40 mg and Harvoni
« Reply #3 on: April 05, 2016, 08:06:30 pm »
Good choice.
There is a lot more knowledge on this concern now. Growing by the day!
CM
Genotype 1a, Biopsy:11/2014: F-1, Tx Naive
Fibrosure, 7/20/15: F-1-2
Pre tx v/l: 1,600,000, ALT: 75, AST: 48
Started generic sofosbuvir & ledipasvir: 10/23/15
4 wk labs: 11/19/15, ALT: 21, AST: 16, V/L:  UND
Started 8 week Harvoni tx: 11/20/15
8 wk labs, 12/15/15, ALT: 15, AST: 13, V/L: UND
4/11/16 12 week EOT-Undetected
7/5/16 SVR 24

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Pantoprazole 40 mg and Harvoni
« Reply #4 on: April 05, 2016, 10:46:11 pm »
Hi Fighter
Pantoprazole is in the same family of medicines as Prilosec it is a PPI or Proton-pump inhibitor and should be taken per the prescribing information sheet instructions for PPI's:

"Proton-pump inhibitor doses comparable to omeprazole 20 mg or lower can be administered simultaneously with HARVONI under fasted conditions."

As your dose is higher that could be a concern unless Pantoprazole 40 mg is equivalent to omeprazole 20 mg.

I discontinued taking Prilosec (omeprazole 20 mg) while I was on treatment I have frequent GERD so it was a long 24 weeks.

If you can take your Pantoprazole you will need to take your dose at the same time as Harvoni on an empty stomach. But if you can avoid taking Pantoprazole while on treatment that would be best to avoid interfering with the absorption of the Ledipasvir component of Harvoni. I just took OTC antacids like Tums well away from my Harvoni dose.

Here is the prescribing information sheet for Harvoni see table 4 page 9

https://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf

good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline HCV_FIGHTER

  • Member
  • Posts: 9
  • This Too Shall Pass
Re: Pantoprazole 40 mg and Harvoni
« Reply #5 on: April 07, 2016, 01:27:49 am »
Hi
Thanks for every one, I went back to my doctor and I show him the gilead durg prescription and finally he agreed  ;) and he said "yes there is an interaction" I stopped taking Pantoprazole and I started my first pill of Harvoni today  ;D

 Thank you again guys.
This Too Shall Pass

 


© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.