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Author Topic: SOF/VEL GS-9857 99% SVR Rate for relapses  (Read 6450 times)

0 Members and 1 Guest are viewing this topic.

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline chino1969

  • Member
  • Posts: 110
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #1 on: May 05, 2016, 02:00:58 PM »
I sincerely hope it works for you.

Offline jakas

  • Member
  • Posts: 252
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #2 on: May 05, 2016, 02:15:19 PM »
Really hopes it works for all of us who need it or will need it
M/55 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and finally SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/17
SVR 63 May 2017

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #3 on: August 16, 2016, 12:03:44 PM »
SVR12......cured . the trial worked and had little side effects
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline FutureThinker

  • Member
  • Posts: 709
  • Onward and upward!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #4 on: August 16, 2016, 02:44:31 PM »
HHburme, do you know how many people were in this study or how many reached SVR12 with it? This is such fantastic news, so very happy research has finally reached this point!!  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #5 on: August 16, 2016, 03:11:08 PM »
Stage 3, 320 people, 50% placebo. 99% cure rate for all GT. One pill a day, 3 meds.
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #6 on: August 16, 2016, 03:17:08 PM »
320 , I don't know if that's USA only or worldwide. Specifically for patients treated with DAA that failed. Only 4 patients in Chicago are where I participated and I was first one finished. In Europe a 99% SVR rate. Epclusa plus a third drug in the pill. I experienced some achy joints, so little SE .
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline FutureThinker

  • Member
  • Posts: 709
  • Onward and upward!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #7 on: August 16, 2016, 03:32:34 PM »
Thanks! This could be the game changer in this fight against HCV.  Looking forward to seeing the final results when they are in.  Congrats again!!!  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #8 on: November 18, 2016, 05:32:41 PM »
Any idea of anticipated FDA approval for this?
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #9 on: November 18, 2016, 06:24:35 PM »
New med SOF/VEL/VOX should be approved within next few months. I was in the clinical trial study for this med after relapsing at SVR12 lab test following 12 weeks of Harvoni treatment. This time SVR12 was UD and SVR24 labs have been drawn but have not yet received yet. Been assured by medical team that it will be UD, but still waiting for final test to be UD. Fingers crossed, feel fine. I experienced aches in my joints, specifically my knees, but really minor sides.
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #10 on: November 18, 2016, 06:36:33 PM »
Very good news, HH

And thank you for volunteering in that trial.

Since Sof/Vel/Vox in pangenotype, with such high success rates, and with mild side effects, it might well be the cutting edge treatment for HCV.

I know they're also looking into 8 week versus 12 weeks for selected patients
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline FutureThinker

  • Member
  • Posts: 709
  • Onward and upward!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #11 on: November 19, 2016, 11:01:12 AM »
HH, FANTASTIC NEWS!! So glad to hear you reached SVR 12 and likely SVR 24.  It was quite the journey for you, but it's now in your past.

Time for a new journey!!  Keep us posted on the SVR 24, FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline easygoing1

  • Member
  • Posts: 12
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #12 on: November 20, 2016, 10:40:53 PM »
Great news HH.... I failed 8 weeks Harvoni treatment. Relapse at 12 week post treatment testing. I had resistance testing and have F2 fibro score 1.2mil count. Geno 1a. Dr. suggested i wait 6 months and wait for new DAA drug. This may be the one I'm waiting for. Hopefully it gets approved. Happy to hear it worked for you and good that you did the trial to test a new drug.

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #13 on: November 20, 2016, 11:05:34 PM »
FT, thx and I'll keep you posted.   
E.G., this drug will be the one ! You have similar story . I relapsed after 12 wks of Harvoni and was resistant to DAA's also. I was hopeless until this trial came along. Just be patient, as I'm told this drug should be approved soon.
The reasons I posted any of this was to hopefully let people like us know that there was hope for us.
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #14 on: November 30, 2016, 02:39:06 PM »
I gather theres little information yet as to whether this sof/vel/vox would be useful for those who fail/relapse on  Epclusa. Since Epclusa has only been out a few months. Outside of the clinical trials, there might not be no such reports as of now, since it wasnt approved until end of June 2016. From the Phase III Epclusa trials, there were only 13 virological failures I believe..

But down the road, I'm hoping this works as well for Epclusa failures as for Harvoni failures. Does anyone if they're planning that?

I'm also thinking this might come to be be the drug used initially, rather than Epclusa. Since a "response guided" approach would allow shortening the time frame to eight weeks for many on it. Possibly depending on rapidity of response. It also seems to have even higher success rate. For some genotypes. Hard to improve much on the 100% for GT2 , though often real life situations arent as great as in clinical settings
« Last Edit: December 01, 2016, 04:32:04 AM by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,533
  • Get tested, get treated, get cured, fight Hep c!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #15 on: November 30, 2016, 04:50:47 PM »
Alright HH so very happy for you!

Your awesome news has made my day!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #16 on: December 12, 2016, 02:15:50 PM »
Gilead has now formally filed a New Drug Application with the FDA

http://www.healio.com/infectious-disease/hepatitis-c/news/online/%7B238deccc-9464-4015-ab81-d6bab9697d8e%7D/gilead-submits-nda-for-investigational-treatment-of-hcv

Question: :

How likely is insurance here to cover this if used as salvage therapy for previously covered DAA treatment?
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #17 on: December 27, 2016, 01:44:03 PM »
SVR24 !!!!! I finally made it !!!
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline jakas

  • Member
  • Posts: 252
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #18 on: December 27, 2016, 02:21:07 PM »
FANTASTIC God Bless  :) :) :)
M/55 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and finally SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/17
SVR 63 May 2017

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #19 on: December 27, 2016, 04:01:38 PM »
Congratulations HHburme

Thank you again for volunteering for that trial. Seems quite effective for re-treatment of DAA failures
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline FutureThinker

  • Member
  • Posts: 709
  • Onward and upward!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #20 on: December 27, 2016, 07:19:30 PM »
HHburme --- SVR 24 !!!!!  HAPPY NEW YEAR TO YOU AND YOURS!!  Hope you have a great 2017, you deserve it!!  The future is very bright, FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,533
  • Get tested, get treated, get cured, fight Hep c!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #21 on: December 27, 2016, 08:05:14 PM »
Wow woo whooooo!

Congrats on finally beating the dragon that is wonderful news so happy for you!!!!!

:)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline easygoing1

  • Member
  • Posts: 12
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #22 on: January 27, 2017, 09:36:40 AM »
After failing Harvoni 8 weeks treatment my Doctor advised waiting six months for a new drug that would be effective treatment on geno type 1a for those with resistant variants. I'm just looking for updates or success stories with similar results. I know many people have been through failed treatment and it's tough waiting after such a let down.

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #23 on: January 27, 2017, 03:45:52 PM »
It does have high success rate for those who failed Harvoni

One question though: Why did the doctor want you to wait six months? Was it a medical reason, or to wait till FDA approval?

Gilead applied for FDA approval for this last month
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline easygoing1

  • Member
  • Posts: 12
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #24 on: January 27, 2017, 04:18:18 PM »
I believe Dr. is waiting for new drug approval. How long does it take for FDA approval after big Pharma submits the drug to the FDA? As soon as I find that a drug is approved I will be calling my Dr. Hopefully in less than six months.
Thanks.

Offline elias

  • Member
  • Posts: 285
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #25 on: January 27, 2017, 04:44:43 PM »
I read this one is expected to be approved~ mid 2017. Please keep us posted
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,533
  • Get tested, get treated, get cured, fight Hep c!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #26 on: January 27, 2017, 10:52:20 PM »
Do you know the name of the medicine you are waiting to be approved? This thread is discussing SOF/VEL trade name Epclusa which was approved Jun 28th 2016.

http://www.gilead.com/news/press-releases/2016/6/us-food-and-drug-administration-approves-gileads-epclusa-sofosbuvirvelpatasvir-for-the-treatment-of-all-genotypes-of-chronic-hepatitis-c

For a timeline Gilead submitted Epclusa for approval in October 2015 and was granted priority review status Jan 4th 2016 so from original application to approval was 8 months but that was faster than normal because of the priority review status.

http://www.gilead.com/news/press-releases/2016/1/gilead-announces-us-fda-priority-review-designation-for-sofosbuvirvelpatasvir-for-treatment-of-all-genotypes-of-chronic-hepatitis-c-infection
« Last Edit: January 27, 2017, 10:59:02 PM by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline HHburme

  • Member
  • Posts: 115
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #27 on: January 11, 2018, 02:27:04 PM »
Vesovi is the name that Gilead gave to my trial drug. Now over  13 months SVR
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline jakas

  • Member
  • Posts: 252
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #28 on: January 11, 2018, 03:40:25 PM »
Glad 13 months and SVR you are free HH. Take care :)
M/55 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and finally SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/17
SVR 63 May 2017

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,533
  • Get tested, get treated, get cured, fight Hep c!
Re: SOF/VEL GS-9857 99% SVR Rate for relapses
« Reply #29 on: January 11, 2018, 06:04:01 PM »
Hey HH congrats on 15 months SVR wow!

I found some info

Vosevi (Sofosbuvir, Velpatasvir and Voxilaprevir)

This is a combination medicine that has been approved to treat adults with chronic HCV, either with no cirrhosis or with compensated cirrhosis, who have already had certain treatments.

Epclusa (Sofosbuvir-velpatasvir)

Pulled this from your study information

ILC2016 Sofosbuvir/velpatasvir and experimental compound GS-9857 shows promise in Hepatitis C infected patients whose previous treatment has failed

Looks like it was approved in Jul 2017. Cutting edge stuff wow!
« Last Edit: January 11, 2018, 06:06:00 PM by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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