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Author Topic: Harvoni/DAAs and less tartar?  (Read 9007 times)

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Offline FutureThinker

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  • Posts: 711
  • Onward and upward!
Harvoni/DAAs and less tartar?
« on: May 04, 2016, 11:44:02 am »
I'm going to ask this on 2 threads, here and in the post-treatment category:

Is anyone noticing less dental tartar buildup while being treated with Harvoni...... or any of the other DAAs for that matter?  I noticed after several weeks on treatment that there seemed to be less tartar during my daily oral hygiene routine.

This could be a good side effect (for a change) ........ thanks for your input, Future Thinker
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Harvoni/DAAs and less tartar?
« Reply #1 on: May 04, 2016, 11:50:39 am »
True for me, too -- my dentist confirmed it at my January appointment, and added that what little tartar there was came off more easily than before my Harvoni treatment.
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Harvoni/DAAs and less tartar?
« Reply #2 on: May 04, 2016, 11:54:22 am »
Interesting! My next dental hygiene appt is a week after I finish my treatment, so I'll get her feedback then and post it.  I just wondered if anyone else had noticed this.  FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline brie41

  • Member
  • Posts: 191
Re: Harvoni/DAAs and less tartar?
« Reply #3 on: May 05, 2016, 07:30:26 am »
Hi,

  I actually did notice that, although my gums started bleeding about a week ago when I floss.  But last night I had a little blood just from brushing.  I have never had that happen.  I stopped using my water pic so I wonder if that is the reason.  I don't think we can always blame Harvoni for everything!  Enjoy the perks!!!  Brie
Logged
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Harvoni/DAAs and less tartar?
« Reply #4 on: May 05, 2016, 12:12:28 pm »
Brie, thanks for answering.  We have 3 for 3 so far on this question, so hopefully we can get more input from more people.  FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Luna7

  • Member
  • Posts: 179
Re: Harvoni/DAAs and less tartar?
« Reply #5 on: May 06, 2016, 12:25:46 pm »
I do have cleaner-feeling teeth, but thought it might be due to these toothbrushes I bought to throwaway during treatment. I used an electric toothbrush before.
Sounds like there might really be something to this tartar lessening during treatment.
Logged
Between F2 & F3
Alt & Ast nearly 100
Viral load over 8 million
Gt 3a

Treated 12 weeks with Sovaldi & Daklinza, start date mid-April 2016
Undetected at 4 weeks into treatment
Alt & Ast  normal
Treatment completed July 14
Most likely will be undetected at 12 weeks (mid October 2016) as symptoms are gone

Offline FutureThinker

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  • Posts: 711
  • Onward and upward!
Re: Harvoni/DAAs and less tartar?
« Reply #6 on: May 06, 2016, 12:31:19 pm »
Thanks, Luna for replying.  I'm wondering what effect drinking so much more water could have on this?  I have literally doubled my water intake since starting treatment, and plan to continue drinking close to what I am now once finished.

Hope we get more input from other members -- Thanks, FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Harvoni/DAAs and less tartar?
« Reply #7 on: May 11, 2016, 01:49:30 pm »
Hi everyone out there -- bringing this question up to the top of the topics to see if there is any more feedback.

Does anyone know if there is a connection between DAAs and decreased tartar buildup?  Or is it the omission of HCV in our systems once we are undetected?  Or is it the increased water intake?  Or a combo????  Thanks!! FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline morab

  • Member
  • Posts: 232
  • Lives in the woods
Re: Harvoni/DAAs and less tartar?
« Reply #8 on: May 11, 2016, 04:25:32 pm »
I doubled water intake, and also notice less tartar on teeth.
Not sure what is the helping matter, removing the Hep C? Or the increase in water.
Morab
Logged
3/2016 G 1a
Alt 84
Ast 62
Fibrosis score lab 0.66
quantitation 894,670
4/23/16 day 6, naive Harvoni 12 week treatment
5/27/16 week 4 lab results UNDETECTED AST 23 ALT17

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Harvoni/DAAs and less tartar?
« Reply #9 on: May 11, 2016, 06:01:30 pm »
My increase in hydration during treatment wasn't drastic -- only a cup or so per day. The reduction in tartar during tx was significant, and I continue to have less tartar even though I've been back to my pre-treatment hydration level ever since I finished tx at the end of September. Perhaps excessive tartar is an extrahepatic manifestation (EHM) of the HCV?

Gnatty
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Harvoni/DAAs and less tartar?
« Reply #10 on: May 12, 2016, 11:54:22 am »
Thanks Gnatty, this is the kind of feedback I'm seeking.  I have been getting my teeth cleaned 3x/year (vs. 2x/year) for awhile now, and I actually cancelled my dental cleaning appt at the end of the month because I really don't need it yet! Rescheduled it for a 6 mos. cleaning vs. 4, so we'll see how that works out.

I hope we get more feedback on this phenomena, as I haven't seen anything as of yet in the literature on this.  FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni/DAAs and less tartar?
« Reply #11 on: May 12, 2016, 06:47:12 pm »
I get my teeth cleaned 3 times a year I have never had a tartar problem. My tartar is unchanged. But I believe my dental does not have to worry about catching hep c from me anymore! ;)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!
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