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Author Topic: Harvoni - Dramatic elevated enzymes during first two weeks  (Read 6302 times)

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Offline MagicMike76

  • Newbie
  • Posts: 1
Harvoni - Dramatic elevated enzymes during first two weeks
« on: June 03, 2016, 05:40:29 am »
 So firstly I am very thankful to be heading into my fourth week of Harvoni treatment.  A little scared here nevertheless.  My ATL and AST levels (113/106 pre-treatment on 5/4  to 154/471 tested on 5/19) shot up dramatically during my first and second week of treatment (158/373 on 5/27).  I am now scheduled to see my doctor this Tuesday and for an ultrasound the following week.   Was drinking water, juicing and taking a multivitamin along with anxiety med (Xanax) that the doc knew about.   I have just been experiencing some abdominal pain along with dry mouth, insomnia with a touch of brain fog.   So far I have quit the Xanax so very curious to see what my 4 week test will look like.   :o
Tested 3/14/2016 - HCV genotype 1a  - VL 30,671,000
Tested 5/4/2016 - ALT 113  AST 106
Started Harvoni TX 5/13/2016
Tested 5/20/2016 - ALT 154  AST 471
Tested 5/27/2016 - ALT 158  AST 373
β€œIt is your life, enthusiastically accept the challenge.”
― Lailah Gifty Akita

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni - Dramatic elevated enzymes during first two weeks
« Reply #1 on: June 04, 2016, 12:35:39 am »
Enzyme levels vary all the time I would not worry about it at this point
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: Harvoni - Dramatic elevated enzymes during first two weeks
« Reply #2 on: June 04, 2016, 06:01:52 pm »
The ALT isn't as troubling as the AST. Are you taking any herbs or dietary supplements? Any alcohol use? Were you taking Xanax before treatment? (Xanax can raise liver enzymes) Glad you have an upcoming appt. Although this is disconcerting, your liver enzymes can go into 5-digits and still be functioning - the liver is incredible. Mostly I wanted you to know that although this is high, the liver is very resilient.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni - Dramatic elevated enzymes during first two weeks
« Reply #3 on: June 04, 2016, 09:37:16 pm »
Thanks Lucinda  for improving on my answer
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: Harvoni - Dramatic elevated enzymes during first two weeks
« Reply #4 on: June 05, 2016, 08:59:33 pm »
It's usually the other way around Lynn. I am humbled by your knowledge and care.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

 


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