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Author Topic: High viral load..effect cure rate from DAA's?  (Read 9853 times)

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Offline NoDarkCloudz

  • Member
  • Posts: 9
High viral load..effect cure rate from DAA's?
« on: July 22, 2016, 11:25:16 pm »
Hi,im on my 4th week of treatment on Solvaldi/Daklinza now.Everythings going great no side effects whatsoever.I just had my first checkup with the clinic nurse and got the bloods taken.il fond out how effective the tx has been in 2weeks.I noticed while with the nurse my viral load was 13.000000 when i started.apparently its quite high.My question is-Does the amount of viral load effect how effective these new DAA's are?? The nurse did mention that some people had higher amd usually after 4wks some came back with only 15! Which she said was basically undetectable and thats hopefully what i should get.Any info would be apprecciated.
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Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: High viral load..effect cure rate from DAA's?
« Reply #1 on: July 23, 2016, 08:23:26 am »
Viral loads doesn't seem to play any part in whether or not you clear the virus. We are hearing people with wildly ranging VL numbers clearing - for example mine was close to 400,000 when I started treatment and I cleared. And then I  know of people here with VLs well into the millions who also cleared.

Don't be surprised if your VL plummets remarkably in the first few weeks. There was someone here on a trial who had their VL taken every few hours for the first couple of days and it dropped dramatically even in that short time, down into the hundreds or maybe even double digits (I've forgotten now but I remember being amazed at how quickly it happened)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline NoDarkCloudz

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  • Posts: 9
Re: High viral load..effect cure rate from DAA's?
« Reply #2 on: July 23, 2016, 08:31:42 am »
Hi philadelphia,
        Thanks for your reply.much appreiciated.Yes it was abit bewildering because from what ive been seeing on this forum the most i saw anyone have was 3-4million so when i saw mine was 13.000000 i was kind of worried.My fibro was 6.1 and apparently this is really good.No cirrhosis.But i cant rememebr the word for it.but my liver was highly inflammed.normal range was 50-90 and i was 148.Im still trying to understand all these terms relating to this desease.But im hoping it should still be all good and the tx is doing its job well.
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Offline BillT

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  • Posts: 573
Re: High viral load..effect cure rate from DAA's?
« Reply #3 on: July 23, 2016, 09:27:35 am »
Hi Dark,
           Like Philly said it is really amazing how quickly the VL drops on these treatments.Your Fibroscan number looks great.I was told they were looking for anything under 7.Mine dropped from 10 to 5.3 on the one I had done recently(6 months EOT).I think once you clear the the virus you'll find that all your numbers will go down nicely.I'm glad to hear you're breezing through this.I love watching dragons die. 8)
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline AussieRosa

  • Member
  • Posts: 226
Re: High viral load..effect cure rate from DAA's?
« Reply #4 on: July 23, 2016, 11:03:57 am »
My viral load before treatment was almost 3 million. At 4 weeks I was undetectable. At 12 weeks post EOT I was still undetectable and therefore cured. I wouldn't worry about viral load numbers until you are EOT. Best of luck for SVR!
Logged
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline FutureThinker

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  • Posts: 711
  • Onward and upward!
Re: High viral load..effect cure rate from DAA's?
« Reply #5 on: July 23, 2016, 01:12:31 pm »
Hi Dark, re: VL numbers, mine ranged between 15 and 3 million over a ~ 5 year span, so don't be alarmed! I also had the virus for over 4 decades.  I remember how alarmed I, too, was when I saw my first VL, so I understand your concern.  They are using the VL at this time to determine length of treatment for some, but that's also still being looked at.  That's why you'll see some folks on 8 wks of Harvoni and others on 12.  My doctor chose 12 weeks of treatment due to my fluctuations over time, despite being at 3 mil when I started treatment.

Hope this helps, FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: High viral load..effect cure rate from DAA's?
« Reply #6 on: July 23, 2016, 01:29:37 pm »
Really the factors common to the most difficult to treat are those with advanced liver disease and those who were prior treatment failures more so than higher viral load.

I treated with interferon based treatment 3 times and was a null responder. I was diagnosed 8 years ago with cirrhosis and my pre treatment fibroscan score was 27. My pretreatment viral load was 2.4 million. But even with all that I was able to be cured.

These new meds are ground breaking curing nearly all.

You will be cured too believe it.
« Last Edit: July 23, 2016, 04:09:46 pm by Lynn K »
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Wiglaf

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  • Posts: 14
Re: High viral load..effect cure rate from DAA's?
« Reply #7 on: July 23, 2016, 03:55:59 pm »
Look at my vl before tx. Hep C virus was undetectable at four weeks.
Logged
Contracted: 1969
Treatment: Naïve
Geno 1A
VL: 15,900,000
ALT 38, AST 37
Belirubin 1.3
TX start date: Mar 2, 2015
Harvoni and Ribavirin (1200 mg)
EOT (24 weeks) 5/25/15 undetected
6 mths post TX: undetected 11/24/15
ALT 10, AST 17
Belirubin 0.8

Offline NoDarkCloudz

  • Member
  • Posts: 9
Re: High viral load..effect cure rate from DAA's?
« Reply #8 on: July 30, 2016, 06:43:47 am »
Thankyou everyone for your replys and much sought after advice and info! Im not as worried now thanks to all you great ppl on this forum.Im into week 5 now.I go to get my first lab results in a few days.I cant wait to see just how affective tx has been,if anything like most ppls experiences have been on here i should well and truly be on the way to that magic word...UND......!! One thing i havent been doing is drink that much water.never really been a good water drinker to be honest.But il try and do better.Besides that everything has been great.Have had vivid and weird dreams ever since the 2nd week of tx..its great!lol  Hope everyone is doing great and heres to a brighter day!:)
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Offline BillT

  • Member
  • Posts: 573
Re: High viral load..effect cure rate from DAA's?
« Reply #9 on: July 30, 2016, 10:47:10 am »
You must be some kind of Goddess to have done the interferon 3 times and survived Lynn.I can't even imagine that.

Are you a good witch or a bad witch? :)
« Last Edit: July 30, 2016, 10:53:18 am by BillT »
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: High viral load..effect cure rate from DAA's?
« Reply #10 on: July 30, 2016, 12:14:33 pm »
Hi Bill

LOL mostly a dragon fighter of old determined to try to beat the thing no matter how difficult to do. When the going gets tough just get tougher and fight on!
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline NoDarkCloudz

  • Member
  • Posts: 9
Re: High viral load..effect cure rate from DAA's?
« Reply #11 on: August 05, 2016, 08:57:55 pm »
Hi guys just like to update..I got my first bloods back (4wk) and im Undetected!! From 13.000000vl to Undetectable is unbelievable! The doc said ive had one of the best results in terms of effectiveness.My liver was highly inflammed before i started treatment,was in the region of 3x the normal functioning level and now im back to totally normal.This daas are a godsend.waited so many years to be in this position i never thought it would come.So keep up the good fight everyone.
         God bless us all ❤️
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Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: High viral load..effect cure rate from DAA's?
« Reply #12 on: August 06, 2016, 12:30:24 am »
Great news No Dark Cloudz. So pleased for you. :)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline brie41

  • Member
  • Posts: 191
Re: High viral load..effect cure rate from DAA's?
« Reply #13 on: August 08, 2016, 09:20:03 am »
Hi,

  Congrats on those numbers!  It is amazing isn't it how powerful these drugs are and yet we barely notice them working their magic!  I also freaked out when first diagnosed and my Doctor told me I had a viral load of 6 million.  My viral load was around 2.5 million when I started treatment.  I also cleared the virus quickly and so far so good.  Hang in there! Brie
Logged
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline BillT

  • Member
  • Posts: 573
Re: High viral load..effect cure rate from DAA's?
« Reply #14 on: August 08, 2016, 10:26:26 am »
By the end of the year they may have to put dragons on the endangered species list. 8)
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Baxter

  • Member
  • Posts: 87
Re: High viral load..effect cure rate from DAA's?
« Reply #15 on: August 08, 2016, 02:33:32 pm »
I was at about 6 million at start of treatment, and tested at 60 at 4 weeks, <15 at 8 weeks, and clear at 12. I'm 8 weeks post treatment now, and still feeling great. A month away from my 12 week post, but you know... when you've been sick 20+ years, you know what it feels like -  and I think you kind of know what it feels like when you're not sick anymore.

It seems more and more clear that high viral loads are not that much of a factor in whether or not DAAs work; the question is whether your particular strain is resistant or not. Evidently the drug either works or it doesn't, regardless of how high your viral load is.
« Last Edit: August 08, 2016, 02:35:20 pm by Baxter »
Logged
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis
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