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Author Topic: SVR 12  (Read 15776 times)

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Offline andrew j

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  • Posts: 477
SVR 12
« on: September 11, 2016, 07:44:58 pm »
I'm clear!! I'm freakin clear!!!
Yay!!!

What a relief!

I just feel - a bit safer, now.
It's like that, eh?
Not well well maybe, but ... better.

A lot of it is down to this place, I reckon.
This place is like ... the place I go.
I check in here every day - even if I don't post that often.

Love you guys.

Offline lporterrn

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  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: SVR 12
« Reply #1 on: September 11, 2016, 09:15:15 pm »
Fantastic! Welcome to a new life of freedom.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: SVR 12
« Reply #2 on: September 11, 2016, 09:53:52 pm »
Congrats Andrew!!! :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #3 on: September 11, 2016, 10:43:56 pm »
It's lovely to hear from you both.
Thankyou.

You know - I was just thinking -
Lucinda, you were the first person I made contact with here at Hep Mag - whenever it was ... maybe 18 months ago.
I live in New Zealand.
Do you remember me?
(I guess you get so many messages? ...).

Kim - I often read your posts, and usually (always!) like them.

Thank you guys,
Andrew.

Offline Baxter

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  • Posts: 87
Re: SVR 12
« Reply #4 on: September 11, 2016, 11:00:37 pm »
Congratulations, Andrew, that's beyond fantastic! I expect that by tomorrow at this time, I'll be posting a similar thread. I had my 12-week test on Wednesday, and I should know the result tomorrow. It's very good news for you, and I hope I soon join your club!
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis

Offline andrew j

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  • Posts: 477
Re: SVR 12
« Reply #5 on: September 12, 2016, 12:57:46 am »
Gee - I hope so too, Baxter.

Lots of love, and prayers,

Andrew.


Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: SVR 12
« Reply #6 on: September 12, 2016, 08:50:17 am »
Wow Andrew, wonderful news! What's the treatment landscape like in NZ?

So happy you've made svr12. :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline FutureThinker

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  • Posts: 711
  • Onward and upward!
Re: SVR 12
« Reply #7 on: September 12, 2016, 12:36:21 pm »
Andrewj --- Thrilled to hear your news and doin' the HAPPY DANCE!!! Welcome to the SVR12 Club!!

I just received my SVR12 ~ 3 weeks ago, and it seems I just really needed to hear those words, "You're still undetected" at 3 mos. post-tx. They took a little time to truly sink in, but once they did, I guess I felt like a weight was lifted off my shoulders, perhaps one that I wasn't acutely aware of as it's been there ever since I was diagnosed in '11. My energy level is also continuing to improve, for which I am very happy.

Enjoy the news and all the best to you -- The future is bright!  FT

Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline brie41

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  • Posts: 191
Re: SVR 12
« Reply #8 on: September 12, 2016, 02:37:17 pm »
Hi Andrew,

  Excellent news and I also joined the svr club not so long ago!  The feeling is still with me and everyday seems a bit brighter!  New Zealand is on my bucket list to visit sometime, how wonderful for you to live there!  Enjoy your new found freedom!  Brie

Baxter,
 
  Good luck to you!   Brie
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #9 on: September 12, 2016, 05:21:41 pm »
Thankyou Philly, FT and Brie,

FT and Brie: Yes - I knew that my timing was generally similar to yours
(and Baxter's) ...

Philly: I will get back to you soon re tx situation in New Zealand.

Lots of love,
Andrew.

Offline Baxter

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  • Posts: 87
Re: SVR 12
« Reply #10 on: September 12, 2016, 06:26:17 pm »
Hi Andrew,

  Excellent news and I also joined the svr club not so long ago!  The feeling is still with me and everyday seems a bit brighter!  New Zealand is on my bucket list to visit sometime, how wonderful for you to live there!  Enjoy your new found freedom!  Brie

Baxter,
 
  Good luck to you!   Brie

Thanks, Brie - today was not the day. The cake and ice cream will still taste just as good tomorrow, though!
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #11 on: September 13, 2016, 07:03:45 pm »
Hi Philly,

Although there is a mix of public and private, NZ's health system is essentially publicly funded.
The Government's procurement agency ('Pharmac') is charged with being as economical (read frugal) as possible.

From July 1st, Viekira Pak has been funded for geno 1s.
For the first three months there are some limitations on access - then, it will be available for all geno 1s.
Harvoni is funded also, but only for those with advanced liver disease.

So - on the face of it - if you have genos 2 - 6, you're out of luck for now.

Hopefully, because we are now hooked in to AbbVie and Gilead, they may be willing to make meds. available for genos 2 - 6 on the QT.
If not - I guess these folks will be stuck with having to go the generic route, with all the edginess this entails.

Offline Lynn K

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  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: SVR 12
« Reply #12 on: September 13, 2016, 07:15:36 pm »
Awesome news Andrew Congrats!!!

Doing the hep c free happy dance!  :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #13 on: September 13, 2016, 07:29:01 pm »
Thankyou, Lynn.

Yes - I do do that dancin' thang!

It's really nice to hear from you again.

Lots of love, eh?
Andrew xx.


Offline morab

  • Member
  • Posts: 232
  • Lives in the woods
Re: SVR 12
« Reply #14 on: September 13, 2016, 07:40:50 pm »
Congrats!!!!!!!!!
I will be joining you in October!
morab
3/2016 G 1a
Alt 84
Ast 62
Fibrosis score lab 0.66
quantitation 894,670
4/23/16 day 6, naive Harvoni 12 week treatment
5/27/16 week 4 lab results UNDETECTED AST 23 ALT17

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #15 on: September 13, 2016, 07:48:02 pm »
Thanks, Morab.

You'll be fine, I'm sure.


Offline morab

  • Member
  • Posts: 232
  • Lives in the woods
Re: SVR 12
« Reply #16 on: September 13, 2016, 09:42:00 pm »
andrew j
I know I am cured, intuition I call it. Some call it having a third eye. Some on this forum will call me crazy.
 I have NO doubts at all about being cured. I was undetected at 4 weeks in.......that is equal to cured! 12 weeks of harvoni,,,,,,,,,,,, when I believe 8 weeks would have done the job.
 The long term effects of Havoni? Not so sure about. Joint problems? Oh yes I do have them post tx.
But yes I WILL be fine.
morab
3/2016 G 1a
Alt 84
Ast 62
Fibrosis score lab 0.66
quantitation 894,670
4/23/16 day 6, naive Harvoni 12 week treatment
5/27/16 week 4 lab results UNDETECTED AST 23 ALT17

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: SVR 12
« Reply #17 on: September 13, 2016, 11:03:14 pm »
Thanks for that info Andrew - interesting! :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #18 on: September 14, 2016, 10:49:43 pm »
Morab,

I got to feeling much more secure - like you seem.
It was largely down to my gastro, who blew a lot of anxieties out of the water
(not entirely, of course) - and who signed me off when I met him at the EOT.

He said to me:
'You won't relapse.
Hep C is an RNA virus. There's nowhere for it to hide' (unlike HIV, which is a DNA virus, apparently) ...
He said :'Even if you had the post-EOT test at 4 weeks, you'd be done and dusted.'
He said: 'You know what it feels like to have Hep C (he was right about that?!).
You'll know if you have relapsed'.

... So, after four or five weeks, I thought:
You know, I'm still feeling better every day.
I must be OK!

Offline Baxter

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  • Posts: 87
Re: SVR 12
« Reply #19 on: September 15, 2016, 12:47:27 am »
He said to me:
'You won't relapse.
Hep C is an RNA virus. There's nowhere for it to hide' (unlike HIV, which is a DNA virus, apparently) ...
He said :'Even if you had the post-EOT test at 4 weeks, you'd be done and dusted.'
He said: 'You know what it feels like to have Hep C (he was right about that?!).
You'll know if you have relapsed'.

... So, after four or five weeks, I thought:
You know, I'm still feeling better every day.
I must be OK!

You've got a good doctor - mine sucks. He never told me anything encouraging like that. In fact, I've only met the man once - a week before I started treatment. Every other visit was with a LNP or PA. Their clinic is nothing but a pill mill for HCV patients.

Which, of course, is OK if that's all you need, and in my case it was all I needed. So no harm.

But what he told you, I had to figure out for myself. By week 4 or 5 post-treatment, I started to realize that if the virus had survived, my viral load would be up by now, and I would be feeling symptomatic. But instead, I was feeling better with each passing week - significantly better. I knew there was still a theoretical possibility that I would relapse, but by the end of 12 weeks, I would have been shocked to learn that I was still sick.
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis

Offline andrew j

  • Member
  • Posts: 477
Re: SVR 12
« Reply #20 on: September 15, 2016, 12:59:41 am »
He was good at dispelling fears and anxieties, yes.

Here in New Zealand you get assigned a specialist through the public health system.
I guess it's similar to the U.S., in that it's pretty much a lottery?
... Professionalism (and their innate intelligence) should result in a service (if not a relationship) that is a substantial resource for their patients.

Offline Baxter

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  • Posts: 87
Re: SVR 12
« Reply #21 on: September 15, 2016, 01:09:55 am »
He was good at dispelling fears and anxieties, yes.

Here in New Zealand you get assigned a specialist through the public health system.
I guess it's similar to the U.S., in that it's pretty much a lottery?
... Professionalism (and their innate intelligence) should result in a service (if not a relationship) that is a substantial resource for their patients.

The desire to keep up with the payments on his Porsche convertible that he parks outside the office during the 2 or 3 hours each day that he actually spends on the premises seems to outweigh any other motivational factors from which he may or may not suffer.
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: SVR 12
« Reply #22 on: September 15, 2016, 01:17:01 am »
When I treated with Sovaldi and Olysio March to June 2014 I was not detected all through treatment and at EOT. I was not tested again until 12 weeks post treatment September 2014.

I got my liver functions back first and my AST had risen back to above normal. I got my viral load back a few days later and my viral load was at 2.4 million slightly higher than my pre-treatment level of 2.0 million. I had no clue I had relapsed until I saw that my ALT had gone above normal. I felt no different before during or after treatment or 12 weeks post when I learned about my relapse.

But anyway enough gloom I am cured now after my 5th treatment with 24 weeks of Harvoni and 15 weeks of ribavirin.

Congrats again Andrew on your SVR 12 the date we all know for sure we are free!
« Last Edit: September 15, 2016, 10:13:20 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

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  • Posts: 477
Re: SVR 12
« Reply #23 on: September 15, 2016, 07:07:50 pm »
That's interesting, Lynn.

You say you felt no different 'before, during or after treatment'.
Maybe that's the key.
I started to feel a bit better even after only four or five days. Like lights slowly coming back on.

I feel a lot better now, but I still live the same smallish life I did when I was unwell.
Maybe it's just about the limitations that have accrued over time.
(I have also been left with some damage, courtesy of the virus (risks I took because of persistent and unrelenting brain fog)).
So I think I'm still recovering from a few things.

I still feel really tired a lot.

Baxter: Ha! Ha! Ha!
Yeah - they're like that here, too - esp. the ones who work mostly in private practice.
Drs and specialists:
There has always been something God-like about them, hasn't there?!


Offline Lynn K

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Re: SVR 12
« Reply #24 on: September 15, 2016, 10:11:18 pm »
I guess when I say I really felt no different is because I never felt bad. If I hadn't donated blood back in 1989 I really never would have known I had hep c. Hep c is called a silent illness it was totally so in my case.

Maybe I am a little tired at times but I push myself a lot. I was taking a college class and working a full time job and part time on a second job and I am 58 after all. But really I am doing my best to never slow down. When I was diagnosed with cirrhosis I did something I hadn't done in years I signed up for a 5 day back packing hike in the Goat rocks wilderness here in Washington State. They advertised it as  beginner hike so not exactly mount Everest but still hiking through the woods for a week.

Ran a 10 K that year. PS never again lol But seriously I need to get back to exercise as I need to loose 25 lbs right now and am currently a couch potato.

Maybe I will sign up for another hike next summer as a motivator to get running again

Best to all
LK
« Last Edit: September 15, 2016, 10:14:25 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

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  • Posts: 477
Re: SVR 12
« Reply #25 on: September 15, 2016, 10:29:14 pm »
Sweet as, Lynn.

Thank you.


 


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