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Author Topic: Started Harvoni treatment today (genotype 1a)  (Read 10335 times)

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Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Started Harvoni treatment today (genotype 1a)
« on: September 23, 2016, 12:33:55 am »
Hello everybody,

Just arrived here in the forum as I started my 24 week treatment with Harvoni today, or 17 hours ago to be exact.
My doctor offered me a 12 week treatment with harvoni+ribavirin, but i refused the ribavirin.
Would love to stay in this forum as the treatment progress and share the experience.
See you all.
Peace
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #1 on: September 23, 2016, 01:21:08 am »
Hi and welcome to the forum

Good luck with your treatment

Have you treated previously?

Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline hummingbird

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  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #2 on: September 23, 2016, 02:33:56 am »
Thank you Lynn,

No, I refused both doing a biopsy and Interferon treatment when I got the HCV diagnose in 2008.
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #3 on: September 23, 2016, 02:56:50 am »
When were you diagnosed with liver cirrhosis in September 2016?
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #4 on: September 23, 2016, 03:24:08 am »
Quote from: Lynn K on September 23, 2016, 02:56:50 am
When were you diagnosed with liver cirrhosis in September 2016?

Yes, I did the fibroscan and bloodtests this month, September 13th actually.
(I will update my footer)  ;)
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Started Harvoni treatment today (genotype 1a)
« Reply #5 on: September 23, 2016, 03:51:37 am »
Welcome, hummingbird. What was your FibroScan score (____ kPa)?

Here's wishing you an easy Harvoni journey (which is what most people have).

Gnatty
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #6 on: September 23, 2016, 03:58:39 am »
Quote from: gnatcatcher on September 23, 2016, 03:51:37 am
Welcome, hummingbird. What was your FibroScan score (____ kPa)?

Here's wishing you an easy Harvoni journey (which is what most people have).

Gnatty

Thank you Gnatty.
I never got any paper with scores or anything from my MD.
Maybe I should require that!?
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Started Harvoni treatment today (genotype 1a)
« Reply #7 on: September 23, 2016, 04:26:53 am »
Yes, it is a good idea to get copies of all laboratory results.
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #8 on: September 23, 2016, 06:23:17 am »
Quote from: gnatcatcher on September 23, 2016, 04:26:53 am
Yes, it is a good idea to get copies of all laboratory results.

Requested copies now.
Will post here as soon as they arrive.  8)
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lilly White

  • Member
  • Posts: 7
Re: Started Harvoni treatment today (genotype 1a)
« Reply #9 on: September 23, 2016, 12:22:00 pm »
Hi all, I'm on day 8. Started walking a few weeks before starting on harvoni and it helped me know that when I feel wobbly now it's not a sideffect. I just wobble a little.  I'll add more to my signature soon. Off to do life
Logged
Started Harvoni 9/16/16

Scheduled for 12 weeks
GT 1a or 1b
ALT 120
AST 61
Fibrospect II   17
Treatment naive


Probably infected in the 70's
Both kids tested negative

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #10 on: September 26, 2016, 11:29:58 am »
My fibroscan was 21,3 kPa
Is that heavy?
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #11 on: September 26, 2016, 11:46:11 am »
Have you discussed this with your doctor? They told you your score and didn't explain your result?

This really needs to come from your doctor but here is a link to the fibroscan score card

https://upload.wikimedia.org/wikipedia/commons/d/de/FibroScan_Scoring_Card_for_Liver_Stiffness_Diagnosis.png

This is from Wikipedia

"From the ten results, the median number is obtained and compared with the designated values on the FibroScan Scoring Card. The scoring card results range from 1.5 kPa to 75 kPa. Between 90–95% of healthy people without liver disease will have a liver scarring measurement less than 7.0 kPa (median is 5.3 kPa)."

For reference my fibroscan score before treatment was 27 back in 2014. I was diagnosed with cirrhosis in Jan 2008 using liver biopsy
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #12 on: September 26, 2016, 01:58:56 pm »
My doctor doesn't provide me with much information unfortunately.
I got the information from my online medic journal.
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #13 on: September 26, 2016, 02:09:14 pm »
What did the online medical journal say?

But again you really need to discuss this with your doctor. Is you doctor a hepatologist? With that kind of fibrosis you really should be seen by a hepatologist preferably associated with a transplant center. Or at least a good gastroenterologist.
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #14 on: September 26, 2016, 06:22:31 pm »
Journal:
Fibroscan 21,3 kPa. IQR 1,1. IQR/median 5%. (Equals an F4)
They will do a ultrasound/x-ray in the next weeks and then decide if the will do a gastroscopy.

What do you think about gastroscopy?
Purpose?
« Last Edit: September 26, 2016, 06:26:56 pm by hummingbird »
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #15 on: September 26, 2016, 09:00:02 pm »
OK I guess you mean an upper endoscopy.

From:

http://www.nhs.uk/Conditions/gastroscopy/Pages/Introduction.aspx

"A gastroscopy is a procedure where a thin, flexible tube called an endoscope is used to look inside the oesophagus (gullet), stomach and first part of the small intestine (duodenum). It's also sometimes referred to as an upper gastrointestinal endoscopy. The endoscope has a light and a camera at one end."

When I was initially diagnosed with cirrhosis my doctor had me get vaccinated against pneumonia, Hep A and Hep B and also to get an upper endoscopy.

Having cirrhosis we can develop pressure in the portal vein (the primary vein in the liver) because the liver being scarred can restrict blood flow. This pressure can cause the veins in the esophagus (swallowing tube) to become enlarged in some cases to the point the veins can burst. These veins are called esophageal varicies my doctor said kind of like varicose veins in you esophagus.

http://www.mayoclinic.org/diseases-conditions/esophageal-varices/home/ovc-20206457

So they are checking you to see if you have this happening and if so if mild they will do a repeat in a couple of years or they could opt to either treat with a beta blocker of possibly band the varicies to cut off blood flow and the tissue will die preventing a dangerous bleeding episode.

On my first endoscopy I had grade 1 varicies so we repeated 2 years later when they had grown more pronounced at grade 2. I was checked again a 1 year later and by then had grade 3 varicies. I could not take a BETA blocker so I underwent 4 upper endoscopies 1 month apart to eradicate them (they can only do so many at one time). I am now checked every year since 2012 and so far I have not had a reoccurance.

Best of luck
« Last Edit: September 26, 2016, 09:01:58 pm by Lynn K »
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline hummingbird

  • Member
  • Posts: 10
  • If you wanna do it, do it Now!
Re: Started Harvoni treatment today (genotype 1a)
« Reply #16 on: September 27, 2016, 02:16:54 am »
Quote from: Lynn K on September 26, 2016, 09:00:02 pm

Best of luck

Thank you Lynn, and thank you for info.

Let's see how it progress.
I will keep on posting here.

Next up will be bloodtests on the 6th october and ultrasound in a few weeks.
Logged
1996: Contracted
2008: Diagnosed genotype 1a
Refused Interferon treatment and biopsy
13/9/16: ALT 5,7 - AST 3,4 - TPK 89
VL HCV-RNA 6,22 log.
Fibroscan 21.3 kPa F4
Ferritin 1389
22/9/16: Tx start Harvoni (24w) (refused ribavirin)
6/10/16: ALT 1,9 - AST 1,1
VL HCV-RNA 2,15 log.
19/10/16: VL HCV-RNA plus 1,18 log.
16/11/16: VL HCV RNA plus < 1,8 log.
18/07/17: VL HCV RNA plus < 1,8 log. ALT 1,4, AST 0,96
Fibroscan 17,1 kPa (pre. 21,3 kPa)
08/02/19: Fibroscan 11,4 kPa !!!!
ALL bloodtests NORMAL!!!
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