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Author Topic: Do you know about upcoming trials for those who failed?  (Read 5330 times)

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Offline mcmaklin

  • Member
  • Posts: 52
Do you know about upcoming trials for those who failed?
« on: November 09, 2016, 06:07:48 am »
Do you know about any clinical trials in London for those who failed previous DAA? genotype 1b or upcoming trials. I cannot find it but where is the phase 3 with GS-9857? I do not want Ribavirin.
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline elias

  • Member
  • Posts: 285
Re: Do you know about upcoming trials for those who failed?
« Reply #1 on: November 21, 2016, 04:47:34 am »
I see no one has answered this yet.

I believe this is the Phase 3 trial you're looking for, except that it says "ongoing but not recruiting":

https://clinicaltrials.gov/ct2/show/study/NCT02607735?term=gilead+sof%2Fvel%2Fvox&rank=4&show_locs=Y#locn

However, you might want to contact someone listed there for further suggestions.

The combination of Sof/Vel/Vox and its success as a "salvage" tx for those who failed earlier tx's was topic at recent  AASLD Liver Meeting

This combination drug was discussed recently on this Forum. I had asked when it might gain FDA approval.  HHburme, who had participated in such a trial, felt it would be approved in a matter of months!!

http://forums.hepmag.com/index.php?topic=4121.0

Maybe try to contact him?

So you might not even need to enroll in a study, if that's the case. IF you can somehow get insurance to approve it
« Last Edit: November 21, 2016, 04:55:50 am by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

 


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