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Author Topic: AbbVie’s Glecaprevir/Pibrentasvir Cures Genotype 1 of Hep C at High Rates  (Read 6659 times)

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Offline Hep Editors

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  • Posts: 784
    • Hep Mag
AbbVie’s investigational, once-daily, fixed-dose combination tablet glecaprevir/pibrentasvir, known as G/P, cured those with genotype 1 of hepatitis C virus (HCV) at high rates in a recent large trial, aidsmap reports. The pangenotypic treatment (meaning it works on all genotypes of hep C) will likely gain approval from the U.S. Food and Drug Administration (FDA) in 2017.
 
Researchers from the Phase III ENDURANCE-1 trial of 703 people with genotype 1 of hep C presented findings at the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston.

For more information...
https://www.hepmag.com/article/abbvies-glecaprevirpibrentasvir-cures-genotype-1-hep-c-high-rates

Offline elias

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  • Posts: 285
Very good news.

I'm still unclear if the "breakthrough" FDA approval track is for GT 1 only? Since the Phase III Endurance 2-4 series show amazing cure rates for GT 2, 3 and 4 as well. So hopefully, approval will be cross-genotype as well

The AbbVie  glecaprevir/pibrentasvir regimen seems on a par with even Gilead's pan-genotypic Epclusa . And similar in its low side effects. It's also promising as a "salvage" treatment for retreating previous DAA failures. Wonder if this competition might force lower prices in Gilead's drugs?
« Last Edit: January 09, 2017, 09:38:57 pm by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

 


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