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Author Topic: Is anyone taking Zepatier HCV treatment for G4?  (Read 8023 times)

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Offline Aussie

  • Member
  • Posts: 11
Is anyone taking Zepatier HCV treatment for G4?
« on: February 19, 2017, 03:16:24 am »
I'm 5 weeks into a 12 week course of Zepatier for genotype 4e.

I had some weird aches and pains in the first week. I still feel the fatigue that started with the commencement of treatment, however, it is reducing as the weeks go by.

I guess my questions are:

Does anyone have G4?

Has anyone cleared HCV with Zepatier?

G1b & G4e (multiple infection)
Infected after blood transfusion as an infant and IV drug use in 1980s
Diagnosed 1986
Currently on Zapatier (started 16-1-17)
No Cirrhosis
VL 46000
ALT 43
AST 48
GGT 51
4 weeks into treatment LFTs are within normal range
ALT 26
AST 29
GGT 24
HCV & VL not tested

8 weeks into treatment
ALT 21
AST 20
GGT 19

Offline Aussie

  • Member
  • Posts: 11
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #1 on: February 22, 2017, 01:44:24 am »
Blood tests results after 4 weeks on Zepatier show significantly improved and within normal range LFTs.
AST 29 (<35)
ALT 26 (<30)
GGT 24 (<35)

No HCV or VL testing done
G1b & G4e (multiple infection)
Infected after blood transfusion as an infant and IV drug use in 1980s
Diagnosed 1986
Currently on Zapatier (started 16-1-17)
No Cirrhosis
VL 46000
ALT 43
AST 48
GGT 51
4 weeks into treatment LFTs are within normal range
ALT 26
AST 29
GGT 24
HCV & VL not tested

8 weeks into treatment
ALT 21
AST 20
GGT 19

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #2 on: February 22, 2017, 04:19:59 am »
Hi good luck on treatment I believe we had a few who were GT 4 but they may have walked off into the sunset after they were cured hopefully someone will chime in :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #3 on: February 22, 2017, 07:42:36 am »
Aussie, while you wait for GT4 forum members to reply, I took a look at the Zepatier prescribing information, a copy of which should have come with your meds, or else see it here: http://www.merck.com/product/usa/pi_circulars/z/zepatier/zepatier_pi.pdf. Section 14.5 gives the clinical trial results for GT4s: 97% reached SVR12 rate (64 of 66 clinical trial patients with GT4 cleared). Since you are female, also note section 8.6 Gender: if your ALT rises later in treatment, you don't need to worry.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Aussie

  • Member
  • Posts: 11
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #4 on: February 22, 2017, 04:28:10 pm »
Hi there Natty and Lynn, thanks for your responses.

Thanks Gnatty for your keen spotting on the medication leaflet. I had accessed online but not completely read it. I have read other reports on independent trials, which I sourced from my university data base. In a trial, which had a larger sample pool of GT4 than the Merke one, the results showed a promising 100% clearance for treatment naive patients after 12 weeks treatment.

I have very little doubt about the end result of clearing the virus, however, my fear is that the research about the possible long term effects of taking these drugs is in its infancy, due to the newness of these anti-virals.

G1b & G4e (multiple infection)
Infected after blood transfusion as an infant and IV drug use in 1980s
Diagnosed 1986
Currently on Zapatier (started 16-1-17)
No Cirrhosis
VL 46000
ALT 43
AST 48
GGT 51
4 weeks into treatment LFTs are within normal range
ALT 26
AST 29
GGT 24
HCV & VL not tested

8 weeks into treatment
ALT 21
AST 20
GGT 19

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #5 on: February 22, 2017, 05:01:54 pm »
True but as you realize there could not be long term testing as no one has taking thes drugs until just recently because they did not exist until just a few years ago. Were there any dates those clinical trials were conducted probably less than in the last few years. So those people were the first.

For me I had no option with having liver cirrhosis due to being infected with hep c for at least 37 years by the time I was cured.

I treated with the old interferon when I was first diagnosed and later interferon and ribavirin. I also later still treated with interferon ribavirin and a clinical trial medicine so having the virus scared me way more than the meds and self administered injections every week.

I also try not to worry about the things I cannot control and especially not to worry about problems that don't even exist except only as a possibility.

Best of luck to you with treatment I am sure you will be fine.

Worry never robs tomorrow of its sorrow, it only saps today of its joy.
Leo Buscaglia
« Last Edit: February 22, 2017, 05:03:52 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Aussie

  • Member
  • Posts: 11
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #6 on: February 22, 2017, 08:17:42 pm »
I have had HCV for possibly 55 years, it is unknown if I was infected by blood transfusion as an infant or as an adult IV drug user in the 80s.

You're perfectly right stating, worrying about possible long term effects is unwarranted, particularly considering the long term damage of HCV. I have been lucky, I escaped cirrhosis and any major health impacts of the virus. My HCV has remained relatively stable since I was diagnosed in 1986 and recent blood tests are showing promising results.

Thanks for your best wishes and extend the same best wishes to you 
G1b & G4e (multiple infection)
Infected after blood transfusion as an infant and IV drug use in 1980s
Diagnosed 1986
Currently on Zapatier (started 16-1-17)
No Cirrhosis
VL 46000
ALT 43
AST 48
GGT 51
4 weeks into treatment LFTs are within normal range
ALT 26
AST 29
GGT 24
HCV & VL not tested

8 weeks into treatment
ALT 21
AST 20
GGT 19

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #7 on: February 23, 2017, 05:06:39 am »
Hi and welcome from another Australian. I'm in regional NSW but my treating specialist is Greg Dore. Nice to have another one of us here. :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Aussie

  • Member
  • Posts: 11
Re: Is anyone taking Zepatier HCV treatment for G4?
« Reply #8 on: February 23, 2017, 03:37:57 pm »
Thanks for the welcome Philadelphia. I'm in Sydney. Now with the new generation treatments and lack of complications with my HCV, I only need a knowledgeable local GP to prescribe and oversee the whole process.
G1b & G4e (multiple infection)
Infected after blood transfusion as an infant and IV drug use in 1980s
Diagnosed 1986
Currently on Zapatier (started 16-1-17)
No Cirrhosis
VL 46000
ALT 43
AST 48
GGT 51
4 weeks into treatment LFTs are within normal range
ALT 26
AST 29
GGT 24
HCV & VL not tested

8 weeks into treatment
ALT 21
AST 20
GGT 19

 


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