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Author Topic: anyone taking or has taken Epclusa, Harvoni or Sovaldi with dilantin or Topamax?  (Read 3010 times)

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Offline tortalbot

  • Newbie
  • Posts: 1
Is anyone taking or has taken epclusa, Harvoni or Sovaldi with dilantin or Topamax and is or was successful? I have a sizure disorder controlled by dilantin looking  for Hep C treatment. Please help.

Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Here is a link to a HCV medications interaction checker. In this case Topamax does not appear to be an issue but Dilantin (Phenytoin?) is not recommended due to potential for reduced plasma levels for both Sovaldi and Harvoni.

http://www.hep-druginteractions.org/checker


A quick check indicates that Dilantin is thought to negatively interact with most/all HCV meds. You and your doctor(s) can use this interactions checker to investigate alternatives to Dilantin that are effective for controlling your seizures while not interacting with the HCV medications.
« Last Edit: April 06, 2017, 10:06:59 pm by Gaj »
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

 


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