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Author Topic: 1a vs 1b treatment  (Read 8199 times)

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Offline Ginabros

  • Member
  • Posts: 28
1a vs 1b treatment
« on: May 24, 2017, 07:34:23 pm »
First of all I want to thank you for the "2016 graduates" thread. I am about to commit to begin  my treatment and reading the success stories is very helpful!

Going through the posts I noticed that most of the time the 1a geno patients took Harvoni and 1b took viekira PAk. Is it because the success rate is better? I could not find any stats for genotype/medication SVR rate.

 I am geno 1b, F2. This will be my first and hopefully the last treatment.

Thanks all!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: 1a vs 1b treatment
« Reply #1 on: May 24, 2017, 08:14:14 pm »
Hi, Ginabros --

In deciding what to prescribe, hepatitis specialists usually follow the AASLD&IDSA HCV Guidance, which is updated whenever new medicines get approved or new scientific studies change best practices. Here is the link: http://www.hcvguidelines.org/full-report/initial-treatment-hcv-infection

Best wishes with your treatment.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: 1a vs 1b treatment
« Reply #2 on: May 25, 2017, 02:40:33 am »
Last I read genotype 1b is easier to cure than 1a. I think they might be going with the less expensive for those easier to treat. Also for 1a who are taking viekira pak they have to take ribavirin along with because 1a is harder to treat while 1b does not need to add the ribavirin.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Ginabros

  • Member
  • Posts: 28
Re: 1a vs 1b treatment
« Reply #3 on: May 25, 2017, 08:37:09 pm »
Thank you Gnatty and Lynn ! I will see what my doc suggest.

Offline jakas

  • Member
  • Posts: 265
Re: 1a vs 1b treatment
« Reply #4 on: May 27, 2017, 03:53:38 pm »
I have 1 a and b and took Harvoni for 12 weeks and got SVR
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: 1a vs 1b treatment
« Reply #5 on: May 28, 2017, 09:51:45 am »
Hi jakas

You were infected with two genotypes both genotypes 1a and 1b? I don't recall you were dual infected.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Ginabros

  • Member
  • Posts: 28
Re: 1a vs 1b treatment
« Reply #6 on: May 28, 2017, 10:29:21 pm »
Thanks for the reply Jakas!  I didn't even know two genotypes are even possible at the same time. ...


My doctor prefers me to start viekira pak.  I have 1b. In my head I was kind of preparing for Harvoni, maybe because it is advertised more and I have heard more people were taking it.  Feeling a little unsettled right now.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: 1a vs 1b treatment
« Reply #7 on: May 29, 2017, 12:37:52 am »
A lot of people have taken viekira pak and been cured. Side effects are similar to Harvoni really the major difference is more pills to keep track of. If you were 1a and had to take ribavirin that makes treatment a little tougher but since you don't need ribavirin your treatment will be similar to Harvoni with the same excellent odds of cure
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline jakas

  • Member
  • Posts: 265
Re: 1a vs 1b treatment
« Reply #8 on: May 29, 2017, 01:07:18 am »
Hi jakas

You were infected with two genotypes both genotypes 1a and 1b? I don't recall you were dual infected.
Went last week to the Hep Doc and he said I have had 1a and 1b I did not know that. Anyway he did a fibroscan and it was just a little less at 24.5 from the previous 27-32 kpa. I insisted on another blood test to reconfirm SVR at 58 weeks. So will know that in a week. My liver function tests have been fine. He was again asking to do a biopsy and I refused. Did an ultrascan too the same day and that was fine.
Put on lots of weight :D. Now need to do something about that ;D
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

 


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