Welcome, Guest. Please login or register.
June 22, 2024, 05:29:30 am

Login with username, password and session length

  • Total Members: 6309
  • Latest: Vicki
  • Total Posts: 55127
  • Total Topics: 4851
  • Online Today: 117
  • Online Ever: 1314
  • (June 22, 2016, 05:23:42 am)
Users Online
Users: 0
Guests: 66
Total: 66


Welcome to the Hep Forums, a round-the-clock discussion area for people who have Fatty Liver Disease, Hepatitis B, C or a co-infection, their friends and family and others with questions about hepatitis and liver health. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

Privacy Warning: Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.
  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.
  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.
  • Product advertisement (including links); banners; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from the Hep Forum Moderators.
Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: treatment failure  (Read 8784 times)

0 Members and 1 Guest are viewing this topic.

Offline treatfailure

  • Member
  • Posts: 5
treatment failure
« on: July 29, 2017, 04:38:59 pm »
In BC Canada and just failed Harvoni treatment. Had DNA testing to identify the drugs I am resistant to (the reason for the fail) and drugs that may work down the road.

I am 1a with stage 4 damage having probably had this thing for 40+ years. BC is not offering re-treatment at this time although they "may" be in a position in the fall of 2018.

I am interested in info on obtaining the "likely susceptible" drugs for my next attempt in a country where I could afford to pay myself.

All info greatly appreciated

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: treatment failure
« Reply #1 on: July 29, 2017, 06:05:35 pm »
Hi treatfailure. And welcome to the forums! Sorry to hear Harvoni didn't work for you.

You might want to have a look at the Redemption eTrials on the FixHepC website. A lot of people are buying their generic drugs that way. Very reliable route. So is Greg Jeffreys. In other words, not necessary to travel overseas anymore to buy generic. You'll find a variety of the new Hep C drugs available through the Redemption eTrials, including Eplclusa. Is that one on the list you were given of drugs that might work for you as retreatment options?

I'm in BC too! Nanaimo.

Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline treatfailure

  • Member
  • Posts: 5
Re: treatment failure
« Reply #2 on: August 01, 2017, 09:00:25 am »
Hi Kim
was not given a list yet, researching possibilities and will discuss with Doc on upcoming visit. One of the drugs i am resistant to is in epclusa as well so looking at Vosevi as my savior

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: treatment failure
« Reply #3 on: August 01, 2017, 09:46:15 am »
Hi Treatfailure - that sure is a bummer. I was going to say vosevi. Fingers crossed it is available for you soon.

My daughter lives in YVR, although I am in Australia. I do love Canada, a beautiful country.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013

Offline treatfailure

  • Member
  • Posts: 5
Re: treatment failure
« Reply #4 on: August 01, 2017, 09:53:36 am »
Its available somewhere

Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Re: treatment failure
« Reply #5 on: August 01, 2017, 09:16:38 pm »
Hi TF,

Vosevi (sofosbuvir/velpatasvir/voxilaprevir) isn't currently available as a generic but based on previous new drug introductions I would expect it to be available within the next couple of months.

There may also be other options that suit your resistance profile as there has been considerable successes during retreatment by adding sofosbuvir to standard treatments that don't already include it per below link. Currently Zepatier is not available as a generic however Viekera + Sof is although it is more expensive than the other generics at about $3k for 12 weeks. Hopefully this may assist in your discussions with your doctor.

Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!


© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.