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Author Topic: Vosevi for Gt 3 failures  (Read 7577 times)

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Offline Coach

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  • Posts: 59
Vosevi for Gt 3 failures
« on: August 07, 2017, 01:27:22 PM »
I took Solvaldi/Rib and relapsed. Vosevi was recently approved by FDA. Has anyone started it or have knowledge of when it will become available??

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #1 on: August 07, 2017, 08:27:16 PM »
Hi, Coach. Gilead is free to sell it, given that the FDA approved it on July 18: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm567467.htm  The question is how quickly insurance companies will cover it. If yours isn't geared up to approve it, you might contact Gilead to see if Gilead will cover nearly all of the cost in your case. Gilead did just that for a lot of us soon after Harvoni was approved, probably to expedite building up market share.

I searched this site and didn't find anyone on Vosevi, but see this post by Gaj:
https://forums.hepmag.com/index.php?topic=5005.msg50990#msg50990

Good luck!

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #2 on: August 08, 2017, 10:44:51 PM »
Thanks Gnatty.

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #3 on: August 27, 2017, 04:28:55 PM »
The Vosevi was surprisingly easy to obtain. It is not yet listed as a specialty drug and I didn't need prior approval from the insurance company. Will be starting next week.

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #4 on: August 27, 2017, 04:44:03 PM »
Amazing! Every good wish to you.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,337
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi for Gt 3 failures
« Reply #5 on: August 28, 2017, 05:09:21 AM »
Alright Coach!

Congrats on getting treatment and good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline lporterrn

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  • Member
  • Posts: 1,821
  • LucindaPorterRN
    • LucindaPorterRN
Re: Vosevi for Gt 3 failures
« Reply #6 on: August 28, 2017, 01:03:09 PM »
Hope you will be posting your experiences. I am very curious about Vosevi (and Mavyret). May you breeze your way to health and freedom.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #7 on: August 28, 2017, 05:41:44 PM »
Thanks Lucinda, I'll keep everyone updated.

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #8 on: September 06, 2017, 09:33:50 AM »
Started the Vosevi this past weekend. My base numbers .  HCV 329,600. HCV RT PCR 5.518 (not sure what this is) AST 33 and ALT 54. So far no sides.

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #9 on: September 06, 2017, 01:28:35 PM »
The 5.518 is just the 329,600 stated as a logarithm (base 10) for the convenience of doctors. Glad you're doing well.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #10 on: September 25, 2017, 04:33:58 PM »
Into my 4th week of Vosevi and I am feeling great .. No side effects. Soo much better then the SOl/ Ribavarin which I had previously. My first blood work came back with Less then 15 viral count , which isn't undetectable but is way down from 329000 which was my base. it was a RNA quantative test so wondering what less then 15 means. ?? Also is this the more accurate test??

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #11 on: September 25, 2017, 05:57:57 PM »
Yes the RNA quantitative test is the best one to determine viral load. The <15 is the sensitivity of that test: if it detects 15 or more international units per ML of blood, it gives an actual number (like the 329,600 you had before treatment). Otherwise,
either
1. If it can't find any at all, the <15 sensitivity will be mentioned in the result, but it'll also say NOT DETECTED (or UNDETECTED or some such term).
or
2. If it finds some hep C, but less than 15 IU/ML, it'll show the <15 without any mention of undetected.

Either way, you are doing just fine. Your viral load is way down after three weeks or less of Vosevi. Glad you continue to feel great on treatment.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline lporterrn

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  • Member
  • Posts: 1,821
  • LucindaPorterRN
    • LucindaPorterRN
Re: Vosevi for Gt 3 failures
« Reply #12 on: September 26, 2017, 03:45:42 PM »
That is wonderful!!!!!!!! Especially the ease of it.
One thing, some labs will state a result as <15 and leave off the word nondetectable or undetected, so if that word is missing, it doesn't necessarily mean that they found something in the low range. As Gnatty said, it is good news.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #13 on: October 02, 2017, 04:19:05 PM »
Just started my 5th week of Vosevi , feeling really well . The only thing I need to do is drink plenty of water. Also got a letter from CVS specialty saying I have to go thru them for the rest of my script. I have to get one more months worth, so hopefully this is not a problem. Going for my 4 week BW tomorrow.

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #14 on: October 02, 2017, 05:32:43 PM »
Coach, glad you continue to feel really well. CVS specialty pharmacy supplied all three of my Harvoni bottles. The CNP supervising my treatment said to place each order as much ahead of time as CVS specialty pharmacy allowed, which worked out fine. Because it was summer, for bottles 2 and 3 I asked for (and got) ice packs, and CVS decided to use overnight shipping, so they came in plenty of time.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline Coach

  • Member
  • Posts: 59
Re: Vosevi for Gt 3 failures
« Reply #15 on: October 06, 2017, 09:49:07 AM »
Got back the BW for 4 weeks on Vosevi and I am cautiously optimistic ..(since I have been down this road before) . The Virus is now UNdetected. My AST-23, ALT-27. The only thing my Doc was a little concerned about was my Hemoglobin was 17.5 and Hematocrit 51.9 both slightly high. Not sure if this is related to meds or not. Doc said to contact my regular doc about this ?? Didn't seem worried. Still no sides, drinking plenty of water.. Feeling fortunate and lucky...

Offline gnatcatcher

  • Member
  • Posts: 1,254
Re: Vosevi for Gt 3 failures
« Reply #16 on: October 06, 2017, 11:30:24 AM »
Yessssss! Rooting for it to stay undetected forever.

If your regular doc is like mine, he won't be concerned about "slightly high." (My hemoglobin and hematocrit have sometimes been a little high.)
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 9.4 kPa [F2-F3]
ALT 15
AST 20
ALP 85

Offline lporterrn

  • Global Moderator
  • Member
  • Posts: 1,821
  • LucindaPorterRN
    • LucindaPorterRN
Re: Vosevi for Gt 3 failures
« Reply #17 on: October 06, 2017, 01:03:28 PM »
This is news that is cause for alcohol-free celebration!!!!!!!
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

 


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