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Author Topic: Olyisio and solvadi connection with chronic uthecaris HIVES  (Read 6521 times)

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Offline Donna P

  • Newbie
  • Posts: 2
Olyisio and solvadi connection with chronic uthecaris HIVES
« on: August 19, 2017, 07:17:11 pm »
Immediately after completing my treatment with olyisio and solvadi. I started getting hives. Bad. Real bad I finished treatment August 2015. September I started getting hives. So so bad that I have to take shots of XOLAIR.   Once a month and it doesn't always work I take multiple antihistamines that Durant always work.  I have t gone a month without them. So frustrating. I was wondering is anyone else hsveing this problem.  Help. 
I am also a breast cancer and colon cancer survivor. I was on herceptin and taxtotere
Radiation. Thanks.  Feeling happy about being hep c free cancer free. Now I want to be hives free. Lol

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Olyisio and solvadi connection with chronic uthecaris HIVES
« Reply #1 on: August 20, 2017, 03:11:20 am »
Sorry to read about your hives ouch.

I also treated with Sovaldi and Olysio for 12 weeks but relapsed and then treated with Harvoni for 24 weeks along with ribavirin for 25 of those weeks. I did not have any skin problems. Not a lot of folks have treated with Sovaldi/Olysio combo and I tend to doubt any one will going forwards.

I hope your doctor can find you some relief for your hives soon
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Donna P

  • Newbie
  • Posts: 2
Re: Olyisio and solvadi connection with chronic uthecaris HIVES
« Reply #2 on: August 20, 2017, 11:05:47 am »
Thanks love.  Let me ask u.  How did u relapse. And why do u think solvadi and olyisio together is no more. 

Offline Lynn K

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  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Olyisio and solvadi connection with chronic uthecaris HIVES
« Reply #3 on: August 20, 2017, 01:06:42 pm »
How did I relapse? Well I was not detected on treatment and at end of treatment of 12 weeks. But 12 weeks later my liver enzymes had returned to above normal and I again had a viral load similar to my pre treatment viral load.

They changed the recommendations when using Sovaldi and Olysio for patients like myself who were prior treaters with advanced liver disease. This revision of treatment duration was recommended shortly after my relapse go figure.

I was a 3 time null responder (no decrease in viral load) to interferon based treatment and was diagnosed with cirrhosis in January 2008. The recommendations for patients like me was changed from 12 to 24 weeks likely I am assuming I would have been successful were I treated for 24 weeks.

I haven't heard anyone lately saying they are using Sov/Oly now with the new generation meds of Harvoni and now many others that have since been approved.

Also for me it was a challenge even being prescribed Sov/Oly as the meds are made by two different manufactures and it was an "off label" use as in not per the prescribing information for either medication at the time back in March 2014.

Best of luck to you.
« Last Edit: August 20, 2017, 01:09:58 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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