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Author Topic: Mavyret Clinical Trial  (Read 6406 times)

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Offline PattheCat

  • Member
  • Posts: 9
Mavyret Clinical Trial
« on: September 16, 2017, 07:33:54 am »
I've relapsed following 12 weeks of Harvoni and, prior to that, relapsed following 12 weeks of Sovaldi/Interferon/Ribavirin.

I now have the opportunity to participate in a clinical trial with 12 weeks of Mavyret. My concern is that the FDA-approved treatment for NS5A inhibitor-experienced patients (me) is 16 weeks of Mavyret. In previous trials, the success rate advertised for NS5A-experienced patients with a 16-week treatment is approximately 94%. The company does not have available data for 12-week treatments of the same population. My concern is that if the 12-week treatment (presumably sub-optimal) is unsuccessful, the treatment may do more harm than good. My insurance company currently does not cover  treatment with Mavyret. Any advice?
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline northfork

  • Member
  • Posts: 55
Re: Mavyret Clinical Trial
« Reply #1 on: September 19, 2017, 11:05:43 am »
Can you get approved for Vosevi? It worked for me after relapsing after 24 weeks on Harvoni and prior to that 24 week clinical trial of 2 other DAAs.
Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline northfork

  • Member
  • Posts: 55
Re: Mavyret Clinical Trial
« Reply #2 on: September 19, 2017, 11:07:03 am »
Can you get approved for Vosevi? It worked for me after relapsing after 24 weeks on Harvoni and prior to that 24 week clinical trial of 2 other DAAs.
Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline PattheCat

  • Member
  • Posts: 9
Re: Mavyret Clinical Trial
« Reply #3 on: September 19, 2017, 08:49:10 pm »
Thanks northfork!

Great news that you were cured earlier this year. Congratulations!

My insurance covers neither Mavyret nor Vocevi. I may just have to wait.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline Pctree

  • Member
  • Posts: 10
Re: Mavyret Clinical Trial
« Reply #4 on: January 04, 2018, 10:56:05 pm »
I've been told that in about a year's time a generic mavyret will be available. Maybe wait then take it with another DAA and ribavarin which are also available in generic form. Lots cheaper and do 3 months as you said. Could be your last chance to knock it on the head

Offline PattheCat

  • Member
  • Posts: 9
Re: Mavyret Clinical Trial
« Reply #5 on: January 05, 2018, 06:52:38 am »
Thanks PCTree!

I actually got approved for 12 weeks of Vosevi. Just finished the regimen and waiting for blood work in April.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline northfork

  • Member
  • Posts: 55
Re: Mavyret Clinical Trial
« Reply #6 on: January 05, 2018, 09:18:13 am »
Hope it worked for you like it did for me!
Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline Ellie123

  • Newbie
  • Posts: 2
Re: Mavyret Clinical Trial
« Reply #7 on: March 07, 2018, 01:47:56 pm »
I've relapsed following 12 weeks of Harvoni and, prior to that, relapsed following 12 weeks of Sovaldi/Interferon/Ribavirin.


I now have the opportunity to participate in a clinical trial with 12 weeks of Mavyret. My concern is that the FDA-approved treatment for NS5A inhibitor-experienced patients (me) is 16 weeks of Mavyret. In previous trials, the success rate advertised for NS5A-experienced patients with a 16-week treatment is approximately 94%. The company does not have available data for 12-week treatments of the same population. My concern is that if the 12-week treatment (presumably sub-optimal) is unsuccessful, the treatment may do more harm than good. My insurance company currently does not cover  treatment with Mavyret. Any advice?


 I was diagnosed with Hep c back in 2004 viral load 1,519,000 as of last week. I tried to get the insurance company to pay for Harvoni, they denied me then the doctor wrote a script for Mavyret and the insurance company denied me twice.  I contacted mavyret directly and asked for the paperwork for the patient assistance program I just got approved for the medication 2 weeks ago at at mo cost. I recommend that you call them directly and ask about that program.  Honestly I am truly blessed that they’re willing to pay for it when no one else would help me .

 


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