Welcome, Guest. Please login or register.
November 22, 2018, 06:39:47 am

Login with username, password and session length


Members
Stats
  • Total Posts: 53120
  • Total Topics: 4401
  • Online Today: 79
  • Online Ever: 1314
  • (June 22, 2016, 05:23:42 am)
Users Online
Users: 0
Guests: 58
Total: 58

Welcome

Welcome to the Hep Forums, a round-the-clock discussion area for people who have Hepatitis B, C or a co-infection, their friends and family and others with questions about hepatitis and liver health. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

Privacy Warning: Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.
  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.
  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.
  • Product advertisement (including links); banners; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from the Hep Forum Moderators.
Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Vosevi log  (Read 7040 times)

0 Members and 1 Guest are viewing this topic.

Offline Patrick226

  • Member
  • Posts: 3
Vosevi log
« on: October 18, 2017, 04:12:15 pm »
First time posting. I was diagnosed in 2011. 26 year old male. Type is 1b. Started Zepatier Nov 2016. UND within 2 weeks. Bloodwork good until  approx 4 months after treatment, I relapsed. I started Vosevi one month ago today. Got first bloodwork done today. Will be keeping a log as I don't see many on here with Vosevi. Few side effects so far, some tiredness. We can beat this!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #1 on: October 18, 2017, 05:04:39 pm »
Welcome, Patrick! May the Vosevi slay your HCV permanently. Thanks for thinking of others: your log and forum participation will be highly valuable.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline sandrooney

  • Member
  • Posts: 43
Re: Vosevi log
« Reply #2 on: October 20, 2017, 04:36:33 pm »
Good Luck. Hope all goes well.

Offline Patrick226

  • Member
  • Posts: 3
Re: Vosevi log
« Reply #3 on: October 23, 2017, 06:59:54 pm »
30 days. Everything was within range with bloodwork, and UND VL. Working full time and going to school, so the tiredness is most likely due to that.

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #4 on: October 23, 2017, 08:05:49 pm »
Glad to read the great news; rooting for things to stay that way!

Full-time work + school = tiredness      makes sense to me.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline singinasong

  • Member
  • Posts: 13
Re: Vosevi log
« Reply #5 on: October 24, 2017, 01:34:06 am »
Awesomesauce! This is good news!  :D
Epclusa, Pre Fibroscan 8.9kPa [F2]
Pre Tx: AST/ALT 67/83 4wks 36/34, 8wks 26/28

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #6 on: October 31, 2017, 10:28:48 pm »
Sounds great Patrick. I am in week 5 of Vosevi. First blood work at 4 wks showed undetected virus. I previously relapsed at 4 wks post tx after 12 wks or Harvoni. Prior to that, relapsed at 4 wks post tx after 12 weeks of Sovaldi, Peg Interferon and Ribavirin. Like you, I have not noticed any side effects.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #7 on: November 01, 2017, 05:37:26 am »
PattheCat, since one purpose of this thread is to be a resource for people on Vosevi, could you let us know how you managed to get the Vosevi? On September 19 you wrote that your insurance didn't cover it. Thanks.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #8 on: November 01, 2017, 06:19:31 am »
When I initially contacted my insurance company and looked on this list of approved medications, Vosevi was not one of them. I confirmed by phone that it was not covered. My doc suggested submitting a request and the request was immediately approved, though I'm not sure on what basis. The same company denied my Harvoni prescription and two appeals. I eventually participated in a clinical trial with Harvoni.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #9 on: November 01, 2017, 06:27:57 am »
Patrick - You say you were clear at 12 wks post tx with Zepatier but then relapsed after 4 months (16 weeks)? Wow, that must have been really disheartening. You must have assumed you were cured when your 12 week labs showed undetected virus. I'm sorry about that but hoping the Vosevi will knock it out for you.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #10 on: November 01, 2017, 08:30:51 am »
Thanks, PattheCat -- glad your insurance company did the right thing!

Patrick and PattheCat, I'm rooting for both of you -- Go Vosevi !

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Patrick226

  • Member
  • Posts: 3
Re: Vosevi log
« Reply #11 on: November 01, 2017, 07:06:42 pm »
Patrick - You say you were clear at 12 wks post tx with Zepatier but then relapsed after 4 months (16 weeks)? Wow, that must have been really disheartening. You must have assumed you were cured when your 12 week labs showed undetected virus. I'm sorry about that but hoping the Vosevi will knock it out for you.

Yes it was. When i was told about my bloodwork, it was like being told i had it again initially. It's all uphill from him. I wish you all success in your treatment. Good vibes!

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #12 on: March 16, 2018, 07:45:54 pm »
I just got the results of my 12-week post-tx labs -

UNDETECTED!!!!!!!!!!!!

Vosevi has delivered!
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #13 on: March 16, 2018, 08:14:40 pm »
Wonderful! -- I'm so glad that you are well past your personal 4-weeks-post-tx danger zone and are now officially CURED!
« Last Edit: March 17, 2018, 07:45:26 am by gnatcatcher »
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #14 on: March 17, 2018, 06:15:00 am »
Thanks Gnatcatcher!

Just looked at your sig and noticed your Fibroscan has gone from F4 to F1-F2. Does that mean your cirrhosis has healed? Wow - that is really encouraging. My Fibroscan prior t o treatment was F1-F2.

I appreciate all the encouragement you provide on this forum.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Vosevi log
« Reply #15 on: March 17, 2018, 07:44:15 am »
Yes, the very first post-treatment FibroScan put me at F3, so I was no longer cirrhotic then. The next was F2-F3, and now F1-F2, so I no longer need ultrasounds 2x/year.

-hope you'll stick around and provide encouragement for others. My time checking the forums is getting more and more limited as my caregiving duties increase.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline PattheCat

  • Member
  • Posts: 9
Re: Vosevi log
« Reply #16 on: March 17, 2018, 07:50:09 am »
Congratulations! That's fantastic.

Yes - I will stick around the forums. I welcome any advice you might have about how I can be helpful to others.
GT 1a
Diagnosed 5/2012
2014 - 12 wks Sov/Peg/Rib, Relapse at 4 wks post tx
2016 - 12 wks Harvoni, Relapse at 4 wks post tx
3/2018 - 12 wks Vosevi - SVR 12!

Offline northfork

  • Member
  • Posts: 54
Re: Vosevi log
« Reply #17 on: March 18, 2018, 10:14:41 am »
Congrats on 12 week SVR. Vosevi is the dragon killer.
Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log
« Reply #18 on: March 31, 2018, 07:10:40 pm »
Hello
I am waiting for Vesevi. I relapsed after Viekira/Exviera in 2015. I have Genotype 1b and L31M in NS5A region.
1. Do I need to take Ribavirin with this? Is there any advantage of Riba with Vosevi?
2. How do you feel on Vosevi?
3. Do you know why you relapsed before?
4. Where do you have your treatment. Thank you

Here my story:
Compl. Viekira no Riba Nov2015. 1b,TT,F1, 1400000U start of treatm. After 2 weeks 120U. After a month below possib of detect. After 3 months UND.3EOT UND. 4wEOT RELAPSED,14Dec2016 VL 27000 IU.mL,Feb 2016 VL 24296 IU/mL,  May 2016 VL 106675 IU/mL .L31M in NS5A.Y93H not pres. No NS3 D168/A/F/H/N/Y
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline northfork

  • Member
  • Posts: 54
Re: Vosevi log
« Reply #19 on: March 31, 2018, 09:14:12 pm »
I relapsed on Daclatasvir and Asunaprevir combo and after 24 weeks of Harvoni. I was told I was NS5a resistant, though I never had a test that I know of. I was in a clinical trial for the first treatment. I was also in a clinical trial for the drug that became Vosevi. I did not take ribavarin with it, and 12 weeks did the trick. 1 year post treatment and undetected. Genotype 1b.
Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log
« Reply #20 on: April 01, 2018, 11:40:48 am »
Congratulations! Any knowledge of simillar cases? I wonder of Ribavirin would add just  a pain of it may do good things. Maybe Vosevi would be enough for me. Any side effects?
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,009
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi log
« Reply #21 on: April 01, 2018, 12:52:43 pm »
Hi mcmaklin

This is from the current recommendations from the AASLD (American Association for the Study of Liver Diseases)

https://www.hcvguidelines.org/treatment-experienced/gt1/ns5a

NS5A Inhibitor DAA-Experienced Genotype 1 Patients

Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)/voxilaprevir (100mg)   12 weeks

Recommended Regimen
Sofosbuvir/Velpatasvir/Voxilaprevir
The placebo-controlled, phase 3 POLARIS-1 trial evaluated a 12-week course of the daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)/voxilaprevir (100mg) in patients with a prior NS5A inhibitor-containing DAA regimen. The majority (61%) experienced a failure with a combination regimen of an NS5B inhibitor plus an NS5A inhibitor, such as sofosbuvir/ledipasvir (Bourliere, 2017). The overall SVR12 rate was 97% (146/150) in genotype 1-infected patients. SVR12 rates were 96% (97/101) for participants with genotype 1a infection and 100% (45/45) for those with genotype 1b infection. A single genotype 1-infected patient experienced relapse; this individual had subtype 1a infection and cirrhosis. Baseline RASs and the presence of cirrhosis were not significant predictors of virologic failure in genotype 1 infection. Serious adverse events were similar between the placebo and treatment arms; only 1 patient discontinued therapy due to an adverse event. Headache, diarrhea, and nausea were more common in those patients receiving sofosbuvir/velpatasvir/voxilaprevir compared to placebo.

This is Vosevi there is no mention of using Ribavirin.

« Last Edit: April 01, 2018, 12:59:27 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline northfork

  • Member
  • Posts: 54
Re: Vosevi log
« Reply #22 on: April 01, 2018, 10:18:56 pm »
Mcmaklin,

The only side effects I had was slight nausea in the morning after taking my pill.
The nausea wore off after a couple of hours.

Probably infected 1969. Diagnosed 2006. Genotype 1b.
Daclatasvir/ Asunaprevir 2013:relapse
Harvoni 24 weeks 2015:relapse
sofosbuvir, velpatisvir, voxillaprevir  trial started on drug 7/16. Viral load 890,000 approx. F2. Undetected after week 1.
12 week SVR achieved Jan 2017.
SVR 24 achieved April 2017 !

60 weeks post treatment...UNDETECTED!

Offline Lukey

  • Member
  • Posts: 309
  • Let Thy Food Be Thy Medicine
Re: Vosevi log
« Reply #23 on: May 10, 2018, 09:17:24 pm »
Viral load 890,000 approx. F2. Undetected after week 1.

That sounds like me. I relapsed Harvoni 8 weeks in 2015. I now have F2 and VL of about 540,000.
I may go on Vosevi soon.  Glad to hear of your UND status.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log
« Reply #24 on: October 25, 2018, 05:37:56 pm »
Dear Friends having Vosevi. WHEN which week on treatment you were UND on vosevi?
1 am week 6 and am <12 detected.
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,009
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi log
« Reply #25 on: October 25, 2018, 07:00:08 pm »
The only test that matters is the 12 week post treatment test result. All on treatment testing is really just to ensure patient compliance as everyone will either test not detected or very nearly so on treatment.

Try not to worry about being weakly detected on treatment. It doesn’t mean anything
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

  • Member
  • Posts: 427
Re: Vosevi log
« Reply #26 on: October 27, 2018, 05:47:20 pm »
Hi mcmaklin,

It's that huge drop they're looking for at week 4 / 5 / 6 - and that's most definitely you!

I had 18 left at about week 5 (Harvoni).
It felt to me as if the thing ... the beast, was finally resolving itself at about week 8.
Don't know if that means anything, or was just a by-product of that hyper sensitivity so many of us feel going through Tx.

It's good that you've got the security of another month's Tx.

You should be fine.

A.

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log
« Reply #27 on: November 02, 2018, 11:38:16 am »
Hello here again.
VOSEVI (not Harvoni, sorry mistake). End of Week 7 this Monday, still detected <12.
I am thnking of making treatment longer a month with Vosevi (paying for this).
I read a few articles here and how should it be, when should it be UND while on treatment? What shall I do?


2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12
7week GGT34, ALT 19.1  AST 26.4, Bili 17,9 , VL<12
« Last Edit: November 02, 2018, 12:31:55 pm by mcmaklin »
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,009
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi log
« Reply #28 on: November 02, 2018, 02:29:13 pm »
Look at some of dragonslayers posts from 2015. He was detected at 4 weeks post treatment but was still able to achieve SVR12. He is still cured today. While his situation was unusual it is not unheard of.

Not detected on treatment is not a requirement. The only test that matters is the one done 12 weeks after you have taken your last pill.
« Last Edit: November 02, 2018, 02:31:17 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

  • Member
  • Posts: 427
Re: Vosevi log
« Reply #29 on: November 03, 2018, 05:58:07 pm »
Hi mcmaklin,

Again - everything looks fine!
Your readings are just where they should be.
There are - or were, when you got your blood test done - a few stragglers left, sure - and you've got - what? - five more weeks of Tx?
Chances are you're already clear!

(If there were more than 50 there - or if there were hundreds - there might be some cause for concern - but that's not the case in your situation) ...

Many have been where you are (I was one of them) - and cleared just fine.

Relax.
All is well!

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log
« Reply #30 on: November 09, 2018, 11:50:24 am »
Hello, news from last tuesday. Undetected! I will also have soon results from Monday from another laboratory.
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,009
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi log
« Reply #31 on: November 09, 2018, 12:36:10 pm »
Congrats!
Now all you need is the 12 week post treatment result to confirm cure
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline mcmaklin

  • Member
  • Posts: 34
Re: Vosevi log please help
« Reply #32 on: November 19, 2018, 10:11:09 am »
Dear Friends, I do not know what to do and what it means.

I was at my official doctor, I told them that I want to buy more Vosevi, they said that they cannot discourage me of this, if I want so.

My labs from official place of treatment from the 5th of Nov UND, I tested myself again the 6th of Nov and  as well UND.

Today I received my labs (as I wanted to make sure what to do - I am going to buy more Vosevi) and my labs from the 15th of Nov (after the beginning of week 10, which is 9 days later) are saying <12 again and that they found the HCV sequence.

I think I should do another test today again.
But what does it all mean.
My labs from the 15th GGT27, Alt 16.5, AST 23.7, Bilirubin High 23,30 and normal would be up to 21, VL <12
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,009
  • Get tested, get treated, get cured, fight Hep c!
Re: Vosevi log
« Reply #33 on: November 19, 2018, 06:29:45 pm »
It means the only test that will tell you if treatment was effective and you are cured is the test for the virus drawn 12 weeks after you have finished treatment.

I assume all testing you are referring to is the HCV RNA by PCR test or similar name that is looking for the Hep C virus itself and none of these tests are an antibody test as anyone who was ever infected with hep c will forever test positive for hep c antibodies.

You can drawn no conclusions or meaning from any on treatment test or even the end of treatment test unless it is definitively positive with a high viral load.

Any test result with a below the LLOQ for the test but detected while on treatment has no clinical significance.

We have had a couple of people here who had similar test results as yours while on treatment who went on to achieve SVR12. The only test that has meaning is the one drawn 12 weeks post treatment all other earlier testing is statistical noise.

Hang in there and best of luck.
« Last Edit: November 19, 2018, 06:33:02 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline badbradley

  • Member
  • Posts: 289
Re: Vosevi log
« Reply #34 on: November 19, 2018, 07:08:39 pm »
Dear Friends, I do not know what to do and what it means.

I was at my official doctor, I told them that I want to buy more Vosevi, they said that they cannot discourage me of this, if I want so.

My labs from official place of treatment from the 5th of Nov UND, I tested myself again the 6th of Nov and  as well UND.

Today I received my labs (as I wanted to make sure what to do - I am going to buy more Vosevi) and my labs from the 15th of Nov (after the beginning of week 10, which is 9 days later) are saying <12 again and that they found the HCV sequence.

I think I should do another test today again.
But what does it all mean.
My labs from the 15th GGT27, Alt 16.5, AST 23.7, Bilirubin High 23,30 and normal would be up to 21, VL <12
July 2018

SVR was achieved by 32/33 patients (97%) with detectable and even by all 14 patients (100%) with quantifiable HCV RNA results at the EOT.

CONCLUSION:
Detectable and even quantifiable HCV RNA results are quite frequent if highly sensitive HCV RNA assays are used. However, treatment prolongation is not indicated, as SVR rates remain high in these patients.



https://www.ncbi.nlm.nih.gov/pubmed/30022590
« Last Edit: November 19, 2018, 07:29:42 pm by badbradley »
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

 


© 2018 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.