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Author Topic: Viral load still detected on Harvoni  (Read 8443 times)

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Offline Suepod1952

  • Member
  • Posts: 4
Viral load still detected on Harvoni
« on: November 02, 2017, 12:24:29 am »
Hi.  Worried about viral load.  Diagnosed July 2017.  Started Harvoni 8/2017.
Fibroscan F0-2. LFT's are always normal.
Starting VL 3.5 million genotype 1a
4 week.  VL. 774
5 week.  VL. 562
6 week.  VL. 484
My DR oadded 4 more wks of Harvoni for a total of 12 weeks. He thinks I have a chance of clearing the virus.  I have six more pills left
Someone on another blog encouraged me to email "Dr. *******" who messaged me back that I was in great trouble and would clearly fail on Harvoni and would go on to become resistant to all other medications.  He scared me to death with this mean email.  My DR just shook his head and said don't believe what you read on the Internet.
Someone recommended this forum as being very helpful. Any insight?
Diagnosed 7/2017
Genotype 1a
Started treatment Harvoni 8/2017. 8 weeks 4 more weeks added
Starting VL 3.5 mil
4 week.VL. 774
5 week.  VL 562
6 week.  VL 484

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: Viral load still detected on Harvoni
« Reply #1 on: November 02, 2017, 01:59:09 am »
I commented to your other post

Try looking up some of dragonslayers posts from about 2.5 years ago.

He was weakly detected at EOT and even at 4 weeks post treatment but he went on to a achieve SVR 12 and remains cured today.

Really surprised they are testing so much while you are on treatment really on treatment testing is of little to no diagnostic value.

Best of luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Viral load still detected on Harvoni
« Reply #2 on: November 02, 2017, 07:25:50 pm »
Suepod1952, it's still much too early. As Lynn said, dragonslayer cleared much later than most but was still cured. Your doctor is correct that the twelve weeks of Harvoni may clear the virus. If by chance Harvoni doesn't cure you, there's something called resistance testing that enables your hepatitis specialist to choose a new medication that you're not resistant to.

Shame on "Dr. *******" for spreading ignorant lies!

Not sure why your doctor is testing your viral load so often, since the test that will indicate a cure is the one you take 12 weeks after the end of treatment. Viral loads are rough indicators at best (they tend to jump around), but the good news is that all three of yours are a lot better than before you began treatment.

Rooting for you,

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline andrew j

  • Member
  • Posts: 477
Re: Viral load still detected on Harvoni
« Reply #3 on: November 03, 2017, 10:11:56 pm »
Hi Suepod,

Yes ... You might have a 'NS5A resistance' - which means that you might be resistant to the action of the ledipasvir component of Harvoni.
That would explain your relatively high VL readings - and why your Dr kept ordering more blood tests.

Those tests have been a blessing in your case, because they have alerted your Dr to a potential problem, and have enabled him / her to order another four weeks of treatment for you.

Those four weeks might make all the difference!

As the others say - you're still in with a good chance - and if this treatment doesn't work, another one will!

Best of luck,
A.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: Viral load still detected on Harvoni
« Reply #4 on: May 02, 2018, 08:55:44 pm »
Hi Suepod

just checking in to see how you are doing I guess you have finished treatment by now.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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