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Author Topic: Liver Cancer & Immune system suppression  (Read 6744 times)

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Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Liver Cancer & Immune system suppression
« on: November 08, 2017, 08:24:05 pm »
Recently there has been some discussion of a possible association between DAAs and liver cancer. However, recent research is now starting to become available that suggests that it may be chronic (long term) inflammation of the liver that is the trigger of immunosuppression.

Quote
”Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that's because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death. But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes cancer by suppressing immunosurveillance -- a natural defense mechanism in which it's thought the immune system suppresses cancer development.

The study is published November 8 in Nature.”

https://eurekalert.org/pub_releases/2017-11/uoc--hci110617.php
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

 


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