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Author Topic: Side effects for Mavyret  (Read 2930 times)

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Offline Bumble

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  • Posts: 8
Side effects for Mavyret
« on: February 09, 2018, 06:14:22 pm »
I have had HCV as far as I know all my life.  I have done the Interferon-Riboviron, sick as a dog, didn't work.  I have been through Harvoni, tired all the time, didn't  work.  Now I  am on my final week of a 16 week Mavyret course.  I have other health issues, and have had to stop taking some meds.  My question to anyone who has been through this is; I am exhausted, how long after you are done with treatment can you expect to rebound.
« Last Edit: February 09, 2018, 06:16:11 pm by Bumble »

Offline 2ndchances

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  • Posts: 10
Re: Side effects for Mavyret
« Reply #1 on: April 13, 2018, 09:41:08 pm »
hi, I can't attest to the rebound time but I can say that my boyfriend is on his 6th week of same treatment and he is exhausted this coming from a guy who's never tired he sleeps all day which is so unlike him. He also has unbelievable heartburn, to the point of almost wanting to postpone treatment but he's fighting through it. I also want to know how you're doing have you rebounded yet from the tiredness? Hope you're doing well and hope to hear from you!

Offline andrew j

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  • Posts: 432
Re: Side effects for Mavyret
« Reply #2 on: April 14, 2018, 06:59:25 pm »
Hi Bumble,

I am about 2 years post-Tx - and I still feel as though I'm recovering.
Tiredness and lack of energy (and some dietary constraints) are still issues for me.
I had Hep C for about 40 years - so maybe my situation isn't entirely different to yours.
Just take it day by day - and look after yourself.
I get the impression you know how to do that?

Best of luck with your results, BTW!

A.

(P.S. My computer has died and I'm using one at the library - so I may not be able to post again in a hurry!) ...

Offline Bumble

  • Member
  • Posts: 8
Re: Side effects for Mavyret
« Reply #3 on: June 04, 2018, 01:45:10 pm »
Mavyret did not work for me .  This was my 3rd try.  My specialist wants me to wait for new advancements, maybe next year.  It makes me so happy that these treatments work for so many., but what about me?  I feel like I am staring at the bottom of an endless pit.  This has been a hearbreaking journey.   Bumble

Offline 2ndchances

  • Member
  • Posts: 10
Re: Side effects for Mavyret
« Reply #4 on: June 04, 2018, 04:44:03 pm »
Hi Bumble,
I just read your post and I literally got tears in my eyes. You had to go through this again to no avail. But with your wonderful attitude and outlook there will be a new tx for you soon!!

Offline Lynn K

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  • Posts: 4,043
  • Get tested, get treated, get cured, fight Hep c!
Re: Side effects for Mavyret
« Reply #5 on: June 05, 2018, 05:42:29 am »
So sad to read this bumble. I am guessing this was your 12 week post treatment test result.

Can I ask what was your viral load before treatment and your viral load on your 12 weeks post treatment test?
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bumble

  • Member
  • Posts: 8
Re: Side effects for Mavyret
« Reply #6 on: June 05, 2018, 08:41:29 pm »
Thanks for the responses.   It was just not right for me.  My team seems to  really dislike  talking to me about viral load.  I know that it is (as of 16 weeks of treatment, and 90 days post) 1.5 million.  It was <12 immediately after treatment.  Now they will want to see what the next generation of drugs might be and may work.  I have a December appointment.  I have been tested for drugs I might be resistance to, and  I am resistant to many of the current drugs.  Thus my dilemma!   It is hard to talk to anyone about this feeling,  a combination of yearning, grief, and resignation.  It will be okay, one way or another.  I will live my life as happily  as I can and wait.
Bumble

Offline Lynn K

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  • Member
  • Posts: 4,043
  • Get tested, get treated, get cured, fight Hep c!
Re: Side effects for Mavyret
« Reply #7 on: June 06, 2018, 12:22:01 am »
Darn I was hoping maybe you were just weakly detected at 12 weeks post. We had a couple of people who were just slightly detected post treatment but eventually cleared the virus that was why I asked.

I treated multiple times with interferon and was a null responder. When the new meds first arrived I was treated for 12 weeks with Sovaldi and Olysio and was not detected at EOT but relapsed when tested again at 12 weeks post. I know how it feels for me I was crushed. Actually, that was my first post here asking if anyone had heard about any relapses on treatment. I was probably the first treatment failure with the new meds here.

I treated again with Harvoni and ribavirin for 24 weeks and was finally cured.

My point is don’t lose hope. They are still working on more effective treatments. Wishing you the best of luck that they can find a treatment that works for you soon.

Most of us here either have hard copies of our lab tests or like me have access to them online. They are your test results, they are yours if you want them.
« Last Edit: June 06, 2018, 12:25:51 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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