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Author Topic: Zepatier Is Safe and Effective for Women on Oral Contraceptives or HRT  (Read 4445 times)

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Offline Hep Editors

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Women with genotypes 1 or 4 of hepatitis C virus (HCV) who are taking oral contraceptives or hormone replacement therapy (HRT) can safely and effectively treat the virus with 12 weeks of Zepatier (grazoprevir/elbasvir).

Researchers conducted a retrospective, post hoc integrated analysis of data from 12 Phase II or III clinical trials of Zepatier. They looked at data on 1,022 female participants with genotype 1 or 4 of hep C, including those who had and had not been treated before. The study cohort included some women with compensated cirrhosis (the milder form of the advanced liver disease) and HIV coinfection. The analysis excluded women with decompensated cirrhosis (the more severe form of the advanced liver disease) or evidence of hepatocellular carcinoma (HCC, the most common form of liver cancer).



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