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Author Topic: Almost Midway Thru 12 wks Vosevi, PCR Results  (Read 1101 times)

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Offline Lukey

  • Member
  • Posts: 307
  • Let Thy Food Be Thy Medicine
Almost Midway Thru 12 wks Vosevi, PCR Results
« on: August 09, 2018, 04:47:58 pm »
At week 5 of 12 on Vosevi :

My WBC are now in the normal range at 4 [3.8-10.8]

My AST and ALT are lower at 18 [10-35] & 12 [9-46]
I almost got all As on my "report card".

In a "reportable range" of 15 to 100,000,000, my VL is <15.

I'm not sure, but I think that's what they call "undetected".
I have about 6.5 weeks to go on Vosevi.

Thank you Gilead.
You made my day.
« Last Edit: August 09, 2018, 04:50:09 pm by Lukey »
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

Offline Lynn K

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  • Member
  • Posts: 3,951
  • Get tested, get treated, get cured, fight Hep c!
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #1 on: August 09, 2018, 06:34:42 pm »
I suppose  different laboratories report in different ways. My lab reports less than 15 not detected. Another possible result is less than 15 virus detected. Your lab may not specify. But anyway less then 15 is a great result good luck with the rest your treatment!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

  • Member
  • Posts: 307
  • Let Thy Food Be Thy Medicine
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #2 on: August 09, 2018, 07:33:25 pm »
The "reportable range" this lab uses is 15 to 100,000,000. Anything under 15 at this lab is as as good as undetectable, because <15 *IS* undetectable at this lab because they cannot detect below 15.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

Offline Lynn K

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  • Member
  • Posts: 3,951
  • Get tested, get treated, get cured, fight Hep c!
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #3 on: August 09, 2018, 11:15:40 pm »
Yeah my lab says they can’t tell if it is 5 or 14 but it knows there are some there just below the tests ability to quantify LLOQ Lower Limit of Quantification
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

  • Member
  • Posts: 307
  • Let Thy Food Be Thy Medicine
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #4 on: August 10, 2018, 04:27:07 pm »
I'd bet I'm UND.

If it's 5 or 14, I doubt it will survive over 6 weeks more of Vosevi.

Thank you.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,951
  • Get tested, get treated, get cured, fight Hep c!
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #5 on: August 10, 2018, 05:00:29 pm »
I would bet the same as well ;)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

  • Member
  • Posts: 307
  • Let Thy Food Be Thy Medicine
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #6 on: August 23, 2018, 01:43:11 pm »
I went to Quest Diagnostics website and I actually was detected at <15 but "not quantifiable". That means I still had a small VL. But with about 7 weeks to go from there, it seems unlikely that a VL of <15 can survive much longer. Is that right?

Do some people get undetected at week 5 on Vosevi?

My AST and ALT are perfect.

I'm supposed to do labs again on Sept 13. I asked to get some more labs right now. I don't know if she'll let me do it. I guess the labs aren't going to affect the Tx outcome anyway but they would be peace of mind.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 3,951
  • Get tested, get treated, get cured, fight Hep c!
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #7 on: August 23, 2018, 02:13:08 pm »
On treatment viral load means little beyond you are compliant with taking your meds.

There have even been a couple of folks here who were weakly detected at EOT and 4 weeks post who went on to achieve SVR at 12 weeks post.

Basically, try not to sweat your viral load test results until 12 weeks post treatment that is the one that counts for all the marbles.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

  • Member
  • Posts: 307
  • Let Thy Food Be Thy Medicine
Re: Almost Midway Thru 12 wks Vosevi, PCR Results
« Reply #8 on: August 23, 2018, 03:47:35 pm »
Interesting. So even if I'm <15 detected at EOT, I might still get SVR. That's cool. Definitely not worth getting upset about. I still have an excellent shot at clearing HCV.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"

 


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