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Author Topic: My First Dr. Appt for Hep C  (Read 1465 times)

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Offline Lullabie

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  • Posts: 4
My First Dr. Appt for Hep C
« on: May 13, 2019, 08:03:02 pm »
I went to my first doctors appt today for my HEP C.  This is the information I received:
Genotype:  1A
Viral Load:  7,120,000
Degree of Liver Damage:  Unknown at this time

I have several appointments for blood and a liver scan before I return to the Doctor on July 31, for evaluation and a treatment plan. 

Can anyone explain to me what the viral load and genotype means? 

Thank you

Offline Mugwump

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  • My number of posts means nothing, piscor ergo sum!
Re: My First Dr. Appt for Hep C
« Reply #1 on: May 13, 2019, 09:13:29 pm »
Genotype 1a was in the past the most difficult to treat. Today your treatment options are so good that your chances of a cure with just one treatment are well over 95 percent.
The different Genotypes of HCV differ in that they have very slightly different sequences of RNA. HCV is a retro-virus and as such is a very tiny block of RNA that encapsulates itself to become active. The virus is not living in the sense that it does not propagate in the same way that organisms with DNA does. It requires complex proteins and proto- proteins that are only created in liver cells to transcribe the genetic information contained with in the viral code.

HCV has a structure which creates a unique shape that allows it to enter hepatocytes (liver cells). This shape is like a skeleton key that allows the encapsulated virus to inject the RNA particle intact into the liver cell at a specific area in the membrane surrounding the human hepatocyte.

The new treatment take advantage of the same structural shape that HCV uses to inject RNA into cells. The new drugs use the same structural shape to inject antivirals directly into liver cells. A very smart biochemical scientist Dr. Micheal Sofia did not listen to the detractors who said it was impossible. So he invented the first drug that used the chemical shape associated with the same key that HCV uses to infect cells called sofosbuvir. Since then many other drugs have become available and are getting better at treating HCV all the time.

The best way forward is to learn as much as you can about the different treatment options open to you and prepare yourself both mentally and physically for being cure quickly. Most importantly keep active and involved with the treatment process and you will do great.

All my best
« Last Edit: May 13, 2019, 09:17:47 pm by Mugwump »
Caution shameless self promotion below :-)

Offline Lynn K

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  • Posts: 4,263
  • Get tested, get treated, get cured, fight Hep c!
Re: My First Dr. Appt for Hep C
« Reply #2 on: May 13, 2019, 09:24:15 pm »
Or another way to think of genotype is like there are many varieties of the flu like bird flu swine flu etc. but they are all the flu. For hep c we have genotypes so just not as fancy names. There are I believe 16 different genotypes with the exciting names of genotypes 1a, 1b, 2a, 2b, etc... the genotype you have will determine which treatment for hep c would be best for you. The other number is your viral load the number of copies of virus circulating in 1 mL of your blood. The viral load doesn’t matter much except they will test you at the end of treatment (EOT) and 12 weeks after treatment has ended to make sure you are Not Detected 12 weeks after finishing treatment to know you are cured. They may test you at 4 weeks into treatment. You should have a huge drop in viral load and will likely be Not Detected at that point but the test that says you are cured is the one at 12 weeks after finishing treatment.

Best of luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!


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