Welcome, Guest. Please login or register.
October 19, 2019, 01:54:27 am

Login with username, password and session length


Members
Stats
  • Total Posts: 54506
  • Total Topics: 4644
  • Online Today: 31
  • Online Ever: 1314
  • (June 22, 2016, 05:23:42 am)
Users Online
Users: 0
Guests: 24
Total: 24

Welcome

Welcome to the Hep Forums, a round-the-clock discussion area for people who have Hepatitis B, C or a co-infection, their friends and family and others with questions about hepatitis and liver health. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

Privacy Warning: Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.
  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.
  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.
  • Product advertisement (including links); banners; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from the Hep Forum Moderators.
Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Question  (Read 1358 times)

0 Members and 1 Guest are viewing this topic.

Offline Kchi23

  • Member
  • Posts: 6
Question
« on: July 14, 2019, 08:03:48 pm »
Over 10 years ago in my early 20’s (I’m now 33) I went to a sexual health clinic for birth control. They decided to do STD testing that included Hep C. I’m not sure why I was tested for Hep C because I had no risk factors. I did use cocaine intermittently in my late teens but other than that no risk factors. I got a call back that my HCV antibodies came back “indeterminate” and I was sent for HCV RNA which came back negative. I was told I could get retested in 6 months but it’s my choice so I’m low risk.  Here I am over 10 years later having anxiety about not being retested. Anyone have experience with “indeterminate” results and is it worth being retested? I have two kids now and have been in a long term monogamous relationship and am freaking out about the possibility of having Hep C and angry at myself for not getting my RNA retested. Seriously this anxiety thing sucks!!! Any feedback would be appreciated.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #1 on: July 14, 2019, 09:28:10 pm »
Very much doubt it is a concern but if your worried get tested then you will know. I suspect that is the only real way you will be able to put you mind at ease.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Kchi23

  • Member
  • Posts: 6
Re: Question
« Reply #2 on: July 26, 2019, 11:39:49 am »
So update..
I got my HCV antibodies rechecked and they came back inconclusive AGAIN
My first antibody screen was reactive and the second supplemental confirmatory screen came back non-reactive. So now I had my blood drawn yesterday for RNA again.

So stressed out over this whole process I just want it to be over. I just don’t understand why my results are coming back inconclusive again was just hoping it would be negative anyways we will see :(

Offline lporterrn

  • Member
  • Posts: 1,984
  • LucindaPorterRN
    • LucindaPorterRN
Re: Question
« Reply #3 on: July 26, 2019, 01:10:31 pm »
Uncertainty is stressful. Hope you get results soon!
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #4 on: July 26, 2019, 05:47:30 pm »
You may consider having the HCV RNA by PCR test that looks for the actual virus not just antibodies. Doing the same test over and over likely will produce similar results.

Just get tested for the virus then you will know for certain.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Kchi23

  • Member
  • Posts: 6
Re: Question
« Reply #5 on: July 26, 2019, 07:39:39 pm »
That’s what I got bloodwork for yesterday the HCV RNA.

I have had a previous negative HCV RNA with inconclusive antibodies so I’m hoping the outcome in the same this time around

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #6 on: July 26, 2019, 09:11:52 pm »
Negative HCV RNA means conclusively you do not have hep c
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Kchi23

  • Member
  • Posts: 6
Re: Question
« Reply #7 on: July 27, 2019, 01:12:07 pm »
Well that’s what I initially thought which is why I never really followed up to be retested.   I was told that 1 negative HCV RNA does not conclusively mean you don’t have Hep C that you always have to be retested especially with inconclusive/indeterminate antibodies. Ugh

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #8 on: July 27, 2019, 07:51:26 pm »
If you don’t have the virus you don’t have hep c. Antibodies only mean you may have been exposed in the past. The HCV RNA test is conclusive in a couple of weeks post a concerning exposure.


Who said you need to be retested?
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #9 on: July 27, 2019, 08:04:17 pm »
“RNA: It measures the number of viral RNA (genetic material from the hepatitis virus) particles in your blood. Your doctor might refer to this as your viral load. They usually show up 1-2 weeks after you’re infected.

What do the results mean?
Negative: You don’t have hep C.
Positive: You have hep C.”

https://www.webmd.com/hepatitis/diagnostic-tests-hepatitis-c-virus
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Kchi23

  • Member
  • Posts: 6
Re: Question
« Reply #10 on: July 27, 2019, 09:03:03 pm »
I was advised by my Physician that I should have been rested 6 months after my first negative HCV RNA because there can be “intermittent viremia” which can cause false negative result so they retest in order to confirm the RNA is still negative 

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #11 on: July 27, 2019, 09:16:33 pm »
I’m not really convinced about that argument unless your possible exposure was extremely recent to your initial testing.

Most general practice doctors don’t know a lot about hepatitis c diagnosis and testing. I’m willing to bet if you spoke with an infectious disease specialist they would say the first HCV RNA if it was more than a couple of weeks post a suspected exposure would me more than adequate from everything I as a lay person have read.

That being said I believe there is no reason to do additional antibody testing. If you want to have an additional HCV RNA by PCR test 6 months after originally performed there is certainly no harm in that if nothing else simply for peace of mind. But I sincerely doubt you will test positive for the virus as you previously tested as not detected. There are some situations with late seroconversion but this is just not that common.
« Last Edit: July 27, 2019, 10:07:25 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Kchi23

  • Member
  • Posts: 6
Re: Question
« Reply #12 on: August 02, 2019, 05:28:11 pm »
Update I did receive my RNA results today and they were negative.  I am very relieved thanks for all the responses and information - I really appreciate it!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,354
  • Get tested, get treated, get cured, fight Hep c!
Re: Question
« Reply #13 on: August 02, 2019, 09:21:47 pm »
Thanks for the update congrats :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.