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Author Topic: on ZEPATIER ..my journey..  (Read 491 times)

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Offline 1bit

  • Member
  • Posts: 25
on ZEPATIER ..my journey..
« on: September 10, 2019, 05:21:56 am »
my ZEPATIER experience

Background: Genotype 1A, infected circa 1999, diagnosed circa early 2000s. A 2006 Liver Biopsy revealed Grade 7 Stage 2 (2/6 ISHAK), Fibroscans 2016 circa 8KPA, previous treatments include Pegylated Interferon + Ribavirin in 2009 (responder/relapser after 48 weeks) and Abbvie3D (Paritaprevir/Ritonavir-Ombitasvir and Dasabuvir) + Ribavirin in 2016 and had to stop after 4 days due to extreme side effects = grey face, yellow eyes, felt like death warmed up and increased heart-rate (200BPM for 7 hours straight on one occasion). I don't have the numbers (but I will get them) but the nurse said my blood tests pre-treatment were good, I will always try to post with the monthly figures. This treatment is for 12 weeks.

I started Zepatier 150MG (50 mg Elbasvir + 100 mg Grazoprevir) yesterday (9,9,19), I took the dose immediately after my tea at 4pm with a Multivitamin and a Paracetamol as I heard headaches were very common so thought I would take a pain-killer upfront, I'm into my second day only and no major 'negative' side-effects yet other than a very very slight sensitivity to loud noises and cold...but that could just be me as I have crippling anxiety, some positive welcome side-effects which are I actually feel a bit perkier since about 1 hour in, its very strange it's like I feel in better stead and have a sense of well-being, my tinnitus has reduced in intensity by about 50%+ too (I recall this also happened in 2009 on INF+RIB).. I have read some reviews by others online and I have come across 2 others who had the same experience (feeling better rather than worse), most others that did get any sides did so after a few weeks.

I will be posting regularly on this thread so that others can see how it affected me, I pray to god its like this for the remainder because if so then I am laughing..
« Last Edit: September 10, 2019, 05:27:08 am by 1bit »
Genotype 1a Infected 1999
- responder/relapser Inf+Rib 2008
- discont. Abbvie 3D (sides) 2016
- commencing Zepatier 2019
Biopsy 2006 = 2/6 ISHAK (Grade 7 / Stage 2)
Fibroscan 2010: 8.9 : (ALT 55)
Fibroscan 2016: 7.9 : (ALT 50)
Viral Load = 9.6 million

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: on ZEPATIER ..my journey..
« Reply #1 on: September 10, 2019, 01:34:08 pm »
Not a lot of people here did Zepatier but many of us took Harvoni which has some similar ingredients. Many of us felt a sort of increased energy while on treatment we called it the “Harvoni high” so other than maybe a couple of mild headaches we actually felt better on treatment rather than worse.

Maybe it is because of having reducing viral load or an effect of the meds I can’t say but yeah for most treatment was easy and many felt better on treatment so rest easy and enjoy the ride to wellness.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline 1bit

  • Member
  • Posts: 25
Re: on ZEPATIER ..my journey..
« Reply #2 on: September 11, 2019, 09:07:38 am »
Day 3 - still no sides.. god I hope it stays like this.

Harvoni High hehe...like it!
Genotype 1a Infected 1999
- responder/relapser Inf+Rib 2008
- discont. Abbvie 3D (sides) 2016
- commencing Zepatier 2019
Biopsy 2006 = 2/6 ISHAK (Grade 7 / Stage 2)
Fibroscan 2010: 8.9 : (ALT 55)
Fibroscan 2016: 7.9 : (ALT 50)
Viral Load = 9.6 million

Offline 1bit

  • Member
  • Posts: 25
Re: on ZEPATIER ..my journey..
« Reply #3 on: September 11, 2019, 09:14:37 am »
I thought I posted this in the ON TREATMENT section>?? can I have it moved if thats ok?  thanks
Genotype 1a Infected 1999
- responder/relapser Inf+Rib 2008
- discont. Abbvie 3D (sides) 2016
- commencing Zepatier 2019
Biopsy 2006 = 2/6 ISHAK (Grade 7 / Stage 2)
Fibroscan 2010: 8.9 : (ALT 55)
Fibroscan 2016: 7.9 : (ALT 50)
Viral Load = 9.6 million

Offline 1bit

  • Member
  • Posts: 25
Re: on ZEPATIER ..my journey..
« Reply #4 on: September 12, 2019, 01:37:08 pm »
DAY 4: Sides are here....  I woke with a raised heartbeat at 3am and rapid shivering, I managed to stop it by taking a paracetamol, drinking water and doing some controlled breath...also doubling up my quilt to heat me up.

I then awoke later than usual and had a bit of a bad gut but thats all... few hours later I went for a walk and 25 minutes in I felt weak, nauseated and dehydrated although I was well hydrated I just felt that way, so I slowly walked back home and felt ok when i got back, 30 minutes later after my tea I started to feel giddy again

so its definitely announced its arrival now, I hope it doesnt get worse because my anxiety is crippling
Genotype 1a Infected 1999
- responder/relapser Inf+Rib 2008
- discont. Abbvie 3D (sides) 2016
- commencing Zepatier 2019
Biopsy 2006 = 2/6 ISHAK (Grade 7 / Stage 2)
Fibroscan 2010: 8.9 : (ALT 55)
Fibroscan 2016: 7.9 : (ALT 50)
Viral Load = 9.6 million

 


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