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Author Topic: Duodenal Mucosal Resurfacing Procedure Improves NASH and Diabetes Markers  (Read 10082 times)

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Offline Hep Editors

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    • Hep Mag
In a recent trial, a new, minimally invasive upper endoscopic procedure called duodenal mucosal resurfacing (DMR) showed promise in improving biomarkers of non-alcoholic steatohepatitis (NASH) and type 2 diabetes in people with the conditions.

The duodenum, which is the first part of the small intestine immediately past the stomach, acts as a key signaling center and a critical regulator of overall balance, or homeostasis, of the metabolism.

Diets high in fat and sugar can cause hyperplasia—overgrowth due to increased cell proliferation—of the lining of the duodenum. This can alter hormone signaling and absorption of nutrients by the organ, which can in turn lead to abdominal obesity, insulin resistance, impaired glucose metabolism, high insulin levels, irregular blood lipids and high blood pressure.

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