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Author Topic: When Will We See Drug Treatments for NASH Fibrosis?  (Read 13005 times)

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Offline Hep Editors

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    • Hep Mag
When Will We See Drug Treatments for NASH Fibrosis?
« on: October 02, 2019, 10:58:04 am »
Perhaps as many as one in four people in North America have non-alcoholic fatty liver disease (NAFLD), in which excess fat accumulates in the liver of an individual who drinks little or no alcohol. The disease is tightly linked with metabolic syndrome and insulin resistance and is a top driver of liver disease, including non-alcoholic steatohepatitis (NASH).

NAFLD and NASH often occur with fibrosis (scarring) of the liver, and yet to date no medications have been approved to treat such liver damage in this population. For anyone with NAFLD and fibrosis, the primary recommended treatment is moderate intensity exercise along with a healthy diet to promote weight loss.


Offline FrancesLarsen

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  • Posts: 2
Re: When Will We See Drug Treatments for NASH Fibrosis?
« Reply #1 on: November 09, 2022, 07:09:02 pm »
Thanks for sharing! I didn't pay much attention to NAFLD until now.

Offline FinleyMorse

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Re: When Will We See Drug Treatments for NASH Fibrosis?
« Reply #2 on: November 10, 2022, 05:38:10 pm »
If I'm not wrong, NAFLD is the same as NASH, and both terms are related to obesity.

Offline Lynn K

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Re: When Will We See Drug Treatments for NASH Fibrosis?
« Reply #3 on: November 11, 2022, 01:21:07 am »
NAFLD is non alcohol fatty liver disease and NASH is nonalcoholic steatohepatitis which is the later stage of liver injury

While NAFLD and NASH are associated with being overweight they can occur in patients who are not obese and can even occur in patients who are considered normal BMI

Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!

Offline FrancesLarsen

  • Newbie
  • Posts: 2
Re: When Will We See Drug Treatments for NASH Fibrosis?
« Reply #4 on: November 12, 2022, 07:58:58 pm »
The prevalence of NAFLD is alarming and the lack of approved treatments is concerning.

Offline iana5252

  • Administrator
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  • Posts: 187
Re: When Will We See Drug Treatments for NASH Fibrosis?
« Reply #5 on: October 16, 2023, 03:29:14 pm »
Resmetirom Improves NASH and Liver Fibrosis in Phase III Trial

Resmetirom, a leading contender in the race to become the first approved treatment for non-alcoholic steatohepatitis (NASH), reduced liver fat accumulation and improved inflammation and liver fibrosis in a Phase III clinical trial, according to results presented at the EASL Congress in Vienna.



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