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Author Topic: Immunodeficiency caused by cirrhosis  (Read 9551 times)

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Offline I fightis thetitis

  • Member
  • Posts: 129
Immunodeficiency caused by cirrhosis
« on: August 14, 2021, 06:48:22 am »
Does anyone know if those with cirrhosis are  immu compromised by Coronavirus?
I'm curious if there are any studies or reports of how the virus affects the liver.

Health to yall!
M59  56@start of TX. date infected:1976
diagnosed 1997 - asymtomatic
Genotype 1a
AST 111 -ALT 124 - AFP -89
Viral Load 1900000 - Log 6.28
Fibro Test F4 ActiTest A3
Harvoni 24 wks - start date 11/24/15

6 Week Labs VL Undetected!
104 weeks EOT Undetected.

8/25/17 Fibrosure score 80 = F4
11/10/17 Fibroscan 7.5 mean 1.6 m/s = F2
8/2018 Ultra sound normal.

Offline Docroccin

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  • Posts: 11
Re: Immunodeficiency caused by cirrhosis
« Reply #1 on: August 15, 2021, 07:26:16 am »
There are a few reports. Have you googled?
This is how I understand it, but I am no expert.
Cirrhosis does not really immunocompromise - which is a reduction in B or T cells (antibodies) - but it does change the cofactors, mainly proteins, that are required for many metabolic processes such as clotting, iron transport, B12 transport and a myriad of others. So you might not recover as well, if infected.
Taking immunosuppressant medications, such as used to treat autoimmune hepatitis and other medical situations that may be related to decompensated cirrhosis,  can suppress antibodies, ie immunocompromise.
Better to get vaccinated and avoid getting the virus.
HCV probably late 1970s, early 80s
IFN 1990s, 9 out of 12 months
Genotype 1a 2019
6 months daclat/sofos
Fibroscan 39
HCV pcr neg May 19

Offline Lynn K

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  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Immunodeficiency caused by cirrhosis
« Reply #2 on: August 19, 2021, 01:28:25 am »
In some regards yes we are immunocompromised but as far as qualifying for a covid booster  I messaged my hepatologist about this. So even though I’m 63 with cirrhosis for 13 years now and a mild heart valve problem they said I’m not considered immunocompromised by the standards of the fda for a covid booster. They are more talking about those who are severely immune compromised like those who have had an organ transplant and are getting immune suppress of drugs or those with HIV we’re not quite to that level.

They did say today that they’re looking at likely having everyone get Covid boosters eight months after they had their second shot so for me that would be the very beginning of December. And of course my doctor says to get my flu shot as early as possible every year so I’ll be doing that shortly.

And yeah there are a lot of studies out there about liver disease cirrhosis and Covid infection.

Best wishes to everybody stay safe out there
« Last Edit: August 19, 2021, 01:30:11 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!


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