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Two Thirds of People With Overweight or Obesity Have Fatty Liver Disease
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Non-alcoholic fatty liver disease (NAFLD) is evident in around two thirds of people with overweight or obesity, according to the results of a meta-analysis published in The Lancet Gastroenterology & Hepatology.
“Obesity is a well-known risk factor associated with NAFLD,” Jingxuan Quek, MBBS, of the National University of Singapore, and colleagues wrote. “[T]hese findings could be pivotal in improving the stratification of the disease burden for future early clinical intervention in overweight and obese individuals, especially at the level of primary care.”
Arising from the accumulation of fat in the liver, NAFLD and its more severe form, non-alcoholic steatohepatitis (NASH), are responsible for a growing proportion of advanced liver disease worldwide, mirroring a global rise in obesity. As a result of inflammation, NAFLD can lead to liver fibrosis, cirrhosis and even liver cancer. With no effective approved medical therapies, management depends on lifestyle changes such as weight loss and exercise.