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Author Topic: Best time to take Harvoni?  (Read 13966 times)

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Offline andrew j

  • Member
  • Posts: 477
Best time to take Harvoni?
« on: March 18, 2016, 06:50:58 pm »
Hi Folks,

Is there a best time of day to take Harvoni?
I have been taking it in the evening with dinner (9 p.m.) - but
have read that in the morning, with breakfast is best.

I'm wondering if I should change ... if it's safe to ... if it matters?

Advice?

Andrew.
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Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Best time to take Harvoni?
« Reply #1 on: March 18, 2016, 09:10:37 pm »
Whatever time works best for you to consistently remember to take your meds.

If you find you have too much energy in the evening and are taking your pill in the evening then adjust you time over several days to earlier in the day.

If you are taking in the morning and find you are feeling more tired adjust your time to later in the day.

The best time of day to take Harvoni is a time of day you will not forget to take it.
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #2 on: March 19, 2016, 01:54:15 am »
Thanks, Lynn.
That's lovely.
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Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Best time to take Harvoni?
« Reply #3 on: March 19, 2016, 02:11:26 am »
Oh yeah I forgot to add Welcome to the forum and good luck on treatment!

:)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline jakas

  • Member
  • Posts: 265
Re: Best time to take Harvoni?
« Reply #4 on: March 19, 2016, 04:03:41 am »
Welcome here. I took it at 6.30 pm everyday. It suited me best just after work and before dinner.
Logged
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Best time to take Harvoni?
« Reply #5 on: March 19, 2016, 07:12:33 am »
your question has been answered, but welcome anyway! :)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline brie41

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  • Posts: 191
Re: Best time to take Harvoni?
« Reply #6 on: March 19, 2016, 07:50:09 am »
Hi Andrew,

  I am new here also and just began taking harvoni this week.  I decided on 6:30pm, right after dinner.  I knew I wouldn't forget to eat dinner!!!  I also set my phone alarm and chart every time I take my pill.  I am sure you have heard this before, but drink plenty of water, it makes all the difference in how you will feel.  Best of luck!!  Brie

My Doctor did stress to decide on the best time and stick with it, and I am taking it at the exact time each day!
Logged
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #7 on: March 19, 2016, 09:16:51 pm »
Thanks, guys.

... Not sure about energy distribution yet, Lynn - but 7-8-9 days in, I am
feeling SO much better!
Yay!!

My thinking has stabilised, after so many years of 'impaired consciousness'
(= 'Brain Fog').

( I probably contracted the virus in 1975 / 76 - and it's been in 'chronic-active'
mode since late 1996).

Best regards, eh?
Andrew.


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Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: Best time to take Harvoni?
« Reply #8 on: March 19, 2016, 09:52:09 pm »
Welcome Andrew! I took my Harvoni at 9:00 each morning. I was one of the people who experienced the "Harvoni High", which for me would last for about 6 hours after taking it. So I was glad to take it in the mornings and have that powering me through the day. Not everyone experiences that though.

best,
kim
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Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline malou

  • Member
  • Posts: 57
Re: Best time to take Harvoni?
« Reply #9 on: March 20, 2016, 07:51:05 pm »
I have been taking mine at about 6:30-7:00 each morning.  And, I must admit, I have tons of energy each day.  Four more pills now and I will be finished with this 12 week course!  ml
Logged
HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #10 on: March 20, 2016, 09:26:03 pm »
Hi Kim and Malou.

Yes - that's the only thing about taking the meds. at night -
I can't really structure in that new-found energy in the same way
you guys can.
It all feels a bit unwieldy!




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Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: Best time to take Harvoni?
« Reply #11 on: March 20, 2016, 09:31:53 pm »
Quote from: andrew j on March 20, 2016, 09:26:03 pm
Hi Kim and Malou.

Yes - that's the only thing about taking the meds. at night -
I can't really structure in that new-found energy in the same way
you guys can.
It all feels a bit unwieldy!

You can shift your time to mornings if you think that would work better for you. I think the advice is to shift your pill time by 2 hrs each day until you get to the time you want.

kim :)
Logged
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Best time to take Harvoni?
« Reply #12 on: March 20, 2016, 10:18:11 pm »
I took mine at 9 p.m. every night.  My theory was that I would be asleep before insomnia set in.  I had plenty of energy and harvoni high in the day.  Welcome to forum...
Logged
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #13 on: March 20, 2016, 11:53:50 pm »
Hmm ...

I'll ponder.
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Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #14 on: March 20, 2016, 11:57:30 pm »
... Thank you guys, BTW.
Your messages are a real help.

xx.


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Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Best time to take Harvoni?
« Reply #15 on: March 22, 2016, 12:35:57 pm »
Hey Andrewj and welcome to the forum! I just finished my first bottle of Harvoni today -- woohoo!! 2 more to go and getting blood work today. My doc stressed it was important to find a time to take that you could remember easily -- I chose to take mine with breakfast as I wanted to take it with food, as some mentioned it is tolerated better that way.  Anyway -- I totally agree with what happened on "Day 7", as that is also when I noticed a significant loss of fatigue.  Some members have had their blood work done in the first week, and their VL has been gone or significantly decreased.  So, this miracle pill works quite fast but it takes a lot of them to get the job totally done. I haven't had any significant side effects thus far, thankfully. These last 28 days have really flown by, so hopefully your time will, too! Much to be grateful for and the future is bright -- FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline andrew j

  • Member
  • Posts: 477
Re: Best time to take Harvoni?
« Reply #16 on: March 22, 2016, 04:00:15 pm »
Thanks, FT.

The increase in energy is great, isn't it? -
... esp. more stabilised thinking (for me, anyway).

For now, I have decided to just stay where I am at 9 p.m.
(... and constantly wonder if ...?!) ...

Anxiety.
Boy - does Hep C know how to do anxiety, eh?

Best regards,
Andrew.
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Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Best time to take Harvoni?
« Reply #17 on: March 23, 2016, 01:26:30 pm »
When people have referred to the "Harvoni High", I really didn't know what they were talking about.  But getting some energy back .... it's hard to describe the extreme fatigue you feel until you don't feel it anymore! When your normal is tired all the time for a very long time, it's hard to distinguish it from a true normal, until you don't feel it anymore! For me, it was like a weighted cloak had been lifted off me. Just can move more easily now instead of feeling so sluggish. It was a very nice surprise effect, to say the least! Take care, FT
Logged
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!
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