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Author Topic: Harvoni and HCC connection?  (Read 19596 times)

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Offline I fightis thetitis

  • Member
  • Posts: 129
Harvoni and HCC connection?
« on: December 23, 2015, 05:38:02 pm »
Hi Everyone,
I have noticed and read of a few individuals in this form that discovered they have HCC towards the end or after treatment.
These were mostly all stage 4 cirrhosis patients.
Most likely they would have developed, or were already carrying the HCC mutations before the start of the Harvoni treatment.
But since the drug is still so new, and I happen to be stage 4, I am curious if there is a connection or an increased incidence of stage 4 cirrhotic patients using Harvoni and HCC?

Specifically, AFP serum markers in the 400-500 range are an indication of "probable" HCC. Although Ultra Sound is more conclusive evidence.
So one way to monitor a connection is for those taking Harvoni to pay attention to their AFP levels before, during and after treatment. Mine were in the 200 range pre treatment, but Ultra Sound showed no lesions. Doc said AFP in that range is inconclusive of HCC. Again stating 400 to 500 is typical for HCC.
IS anyone else monitoring their AFP levels? Thoughts or articles?

Started week 4 Harvoni and so far sides are mild.. I have noticed working out, at least walking for 45 min a day REALLY helps. Along with the mandatory 2 quarts or more "water irrigation."

Good luck with treatment.
Merry Christmas everyone!

Greg in Cali
Logged
M59  56@start of TX. date infected:1976
diagnosed 1997 - asymtomatic
Genotype 1a
AST 111 -ALT 124 - AFP -89
Viral Load 1900000 - Log 6.28
Fibro Test F4 ActiTest A3
Harvoni 24 wks - start date 11/24/15

6 Week Labs VL Undetected!
104 weeks EOT Undetected.

8/25/17 Fibrosure score 80 = F4
11/10/17 Fibroscan 7.5 mean 1.6 m/s = F2
8/2018 Ultra sound normal.

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Harvoni and HCC connection?
« Reply #1 on: December 23, 2015, 08:12:11 pm »
I'm not an expert on HCC so take all this with a grain of salt. It's just my thoughts written down, worth exactly what you paid for them.

My AFP was 76 at the start of Tx. It had been climbing over the years. At 12 weeks post treatment it was 8. When I asked my specialist what a level like my starting one meant he said- to him, an AFP like that was indicative of cirrhosis, that's about it. A drop is great of course, but my beginning Tx number didn't seem to worry him overly. Normal lab values for my lab are 0 - 7.

My u/s 12 weeks post showed no changes from the previous one in April, nothing untoward except of course all the crap that goes with being cirrhotic.

I walked every day and like you, found it an excellent therapy!
« Last Edit: December 23, 2015, 08:14:34 pm by Philadelphia »
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline gnatcatcher

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  • Posts: 1,372
Re: Harvoni and HCC connection?
« Reply #2 on: December 23, 2015, 08:15:22 pm »
Greg, in the USA the protocol for people with F4/cirrhosis seems to be an AFP test and an ultrasound every six months. My hepatologist follows that protocol and says HCC is very treatable if caught early. AFAIK that protocol is the same no matter what treatment the person is/was on.

Different labs have different normal ranges for the AFP serum tumor marker. At my PCP's lab, normal is <6.1 NG/ML. My personal results were 5.3 in March (several months before I began Harvoni Tx) and 4.6 in mid-September (when I was nearing the end of Tx). Thus, in my case, Harvoni Tx made HCC less likely.

Glad your sides are mild. I, too, fared better by getting exercise and staying well hydrated. Have a wonderful holiday season.

Gnatty
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni and HCC connection?
« Reply #3 on: December 24, 2015, 12:03:32 am »
Yeah it is a cirrhosis HCC connection not a Harvoni HCC connection in my book. From what I have read if you don't yet have cirrhosis you are not at risk for HCC. Cirrhosis is what puts us at risk for HCC.

I have been getting my AFP and abdominal ultra sound every 6 months since Jan 2008 as everyone who has cirrhosis should per the protocols for monitoring patients with cirrhosis.

My results before I treated were 26.6 & 26.3

After I finished Sovaldi/Olysio in 2014 and before I found out I had relapsed it was down to 14.9

When I started Harvoni it was at 15.6 and 13.4 when I finished.

My most recent 6 months post Harvoni and at SVR24 my AFP was 10.4 the lowest I have ever seen it with the standard range for my lab 0.0 to 8.3 ng/mL

So my liver is much happier than it has been in years and I am excited to see what the new year brings.

Happy livers to all and too all a good night!
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Debula

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  • Posts: 257
  • "Your body hears everything your mind says"
Re: Harvoni and HCC connection?
« Reply #4 on: December 29, 2015, 03:07:02 pm »
Hi Everybody and Happy Holidays!
I was actually thinking of starting a thread like this too.  Just to put it out there since I am one of those that developed HCC after starting Harvoni. 

I don't want to think that our miracle cure drug could possibly be linked to my HCC
What is odd to me is that I have had cirrhosis for a very long time and not until I started Harvoni did the HCC pop up.  I know it is probably a coincidence though.
And now with the lung lesions who knows.......

My AFP is 9 and I don't know what it was before or if they even checked it before.

I hope everybody with cirrhosis is getting their 6 month ultrasounds done in a timely manner.  I was 2 months late and have been waiting 3 months for a treatment plan.   >:(  ......so although diagnosed early enough ..................

Happy New Year Everyone
May 2016 bring us all SVR
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline Lynn K

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  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni and HCC connection?
« Reply #5 on: December 29, 2015, 05:30:47 pm »
Hi Debula

Good to hear from you and hoping with all my heart you get good news soon.

Have you got any more information about those lung lesions?

Hugs to you
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Re: Harvoni and HCC connection?
« Reply #6 on: December 30, 2015, 09:16:10 am »
Hi all,

From what my specialist tells me it is the cirrhosis that puts you at risk, more so when the cirrhosis continues to progress as with aggressive HCV or continued excessive alcohol. AIUI your liver will always attempt to repair itself and regenerate, but if it is sustaining further damage to the regeneration sites then that will drive HCCs. He put it to me that achieving SVR wouldn't totally remove the risk and I will always require monitoring but it would considerably reduce the risk which was one of the factors behind my decision to treat with generics with his script and support.
I was recognised as a risk previously so monitored 6 monthly via scans and AFP but when my LFTs started to rise again they put me on 3 monthly which picked the first up via AFP and scan at the next tests, then repeat 6 mths later. Latest 4 week Tx bloods show dropping AFPs.

Gaj
Logged
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline lporterrn

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  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: Harvoni and HCC connection?
« Reply #7 on: December 30, 2015, 02:03:26 pm »
We know there is a link between HCC and cirrhosis, and the only way to cure hep C and hope for a chance to reduce the HCC risk is with treatment. However, it doesn't always happen. As for a link between Harvoni and HCC, my theory is that people are discovering their HCC sooner if they are on Harvoni  or in post-Harvoni follow-up. I believe the HCC would have happened anywise, but it would have been caught later and that isn't good.

Only a theory...
Logged
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Harvoni and HCC connection?
« Reply #8 on: December 30, 2015, 02:13:39 pm »
My specialist told me (and my GP) that by successfully completing treatment and having my AFP levels drop I had reduced my risk of HCC to around 1%. Now that may or may not mean anything to me - lies, damned lies and statistics etc, but I like to cling to it.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Debula

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  • Posts: 257
  • "Your body hears everything your mind says"
Re: Harvoni and HCC connection?
« Reply #9 on: December 30, 2015, 03:27:47 pm »
Quote from: Lynn K on December 29, 2015, 05:30:47 pm
Hi Debula

Good to hear from you and hoping with all my heart you get good news soon.

Have you got any more information about those lung lesions?

Hugs to you
Lynn

Hi Lynn
I go for the biopsy tomorrow for the lung lesions.  Will post when I know more
Hugs to you too!
Deb
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: Harvoni and HCC connection?
« Reply #10 on: December 30, 2015, 03:58:25 pm »
Quote from: Debula on December 30, 2015, 03:27:47 pm
I go for the biopsy tomorrow for the lung lesions.  Will post when I know more

Good luck tomorrow Deb! Will be thinking of you. :)

kim
Logged
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: Harvoni and HCC connection?
« Reply #11 on: December 30, 2015, 04:27:14 pm »
Quote from: KimInTheForest on December 30, 2015, 03:58:25 pm
Good luck tomorrow Deb! Will be thinking of you. :)

kim

Thank you!! It means a lot!!
Happy New Year Kim!!

Deb
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Harvoni and HCC connection?
« Reply #12 on: December 30, 2015, 04:47:13 pm »
Debula, I'm holding space in my heart for this all to work out with as little impact as possible for you!  Sending love... Bree 8)
Logged
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline MaryC

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  • Posts: 117
  • Life is not a sprint; it's a marathon.
Re: Harvoni and HCC connection?
« Reply #13 on: December 30, 2015, 06:59:12 pm »
Deb...I am so sorry to hear - it must be so incredibly stressful for you now.  Good luck to you tomorrow.  Keep your spirits up as best as you can.  You can get through this...you dealt with the HCV all these years!
Mary
Logged
GT 3a
Dx'd 4/15 not known when contracted
Labs 7/15:
-VL 537,000
-AST 32
-ALT 41
-Fibrosis score 0.46 (F1-F2)
Started tx 9/17/2015 with Daklinza + Sovaldi
6/6/16: 24 week EOT SVR!  Cured!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Harvoni and HCC connection?
« Reply #14 on: December 30, 2015, 07:42:29 pm »
Debula, I'll be sending loving thoughts your way this evening and tomorrow.
" . . .
Deep peace of the flowing air to you
Deep peace of the quiet earth to you
Deep peace of the shining stars to you
Deep peace of the gentle night to you
Moon and stars pour their healing light on you
. . . "

Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni and HCC connection?
« Reply #15 on: December 31, 2015, 04:01:48 am »
Good luck and hoping for good results for you

<3

Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline jakas

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  • Posts: 265
Re: Harvoni and HCC connection?
« Reply #16 on: December 31, 2015, 09:32:30 am »
Good Luck and my prayers for you
Logged
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Harvoni and HCC connection?
« Reply #17 on: December 31, 2015, 12:52:51 pm »
Ditto from Beto Debula...prayers a comin'

Gnatty, listens to Bill Douglass...Deep Peace...
Logged
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Philadelphia

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  • It only looks like I know what I'm doing
Re: Harvoni and HCC connection?
« Reply #18 on: December 31, 2015, 12:59:20 pm »
All the best Debula.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Harvoni and HCC connection?
« Reply #19 on: December 31, 2015, 01:16:30 pm »
Sending good vibes your way, Deb. ~ ~ ~ ~ ~
Logged
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Harvoni and HCC connection?
« Reply #20 on: December 31, 2015, 01:20:22 pm »
Quote from: beto on December 31, 2015, 12:52:51 pm
Gnatty, listens to Bill Douglass...Deep Peace...
No, never heard him (not fond of vocal music unless it's birds doing the vocalizing). A friend who visited Ireland gave me a bookmark with the words on it. I've got the bookmark on my desk as another reminder to send Debula peaceful, loving thoughts throughout the day.
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: Harvoni and HCC connection?
« Reply #21 on: January 07, 2016, 02:57:54 pm »
Hi everybody and HAPPY NEW YEAR!!
Thank you all so very much for your thoughts and prayers and support.
I found out yesterday that the lung biopsy came back clear and we are moving forward with the resection next Friday!! Finally a light at the end of the tunnel. :)
The surgeon said that the tumor is located on the outer edges and I won't loose but 10% of my liver which is way better than I expected.
My pain is still pretty extreme but hopefully it will be over soon and I can start fighting my way back to health.  (I haven't been able to eat much this past week or so so my body is pretty run down)

Again, your support is really really appreciated.  What woukd I do without you guys?
Blessings to all
Deb
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline gnatcatcher

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  • Posts: 1,372
Re: Harvoni and HCC connection?
« Reply #22 on: January 07, 2016, 03:13:49 pm »
Debula, this is WONDERFUL! Now we can concentrate our thoughts and prayers on relief of your pain and regeneration of that 10% of your liver.

Gnatty
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline KimInTheForest

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Re: Harvoni and HCC connection?
« Reply #23 on: January 07, 2016, 03:16:13 pm »
FABULOUS NEWS, DEB! I am so happy for you, and that you are finally able to move forward with a plan of action.

As for not being able to eat much and getting run down from that... I am sure you have tried smoothies - fruit, veggies, juice, yogurt... That is what I did during treatment when I had zero appetite. I still lost 15 lbs during & post-tx (which was significant for me since I was skinny to start). But the smoothies helped me nutritionally through that difficult time.

Best of luck with the resection,
kim
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Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline beto

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  • "no risk it, no biscuit"
Re: Harvoni and HCC connection?
« Reply #24 on: January 07, 2016, 03:20:16 pm »
wow Debula...this is fantastic news.  Prayers moving forward to a complete recovery.  Like Gnat said...that 10% will be back lickitysplit.  :)
Logged
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Harvoni and HCC connection?
« Reply #25 on: January 07, 2016, 04:13:53 pm »
So happy to hear that there is a plan for you for you and it's better than you expected Debula!  That sounds like you have every reason to be optimistic for a full and complete recovery!  We're all here holding the space for you for your best possible outcome. :)
Logged
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline jakas

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  • Posts: 265
Re: Harvoni and HCC connection?
« Reply #26 on: January 07, 2016, 04:24:16 pm »
Good news, hope all goes well and our prayers are with you. God bless and I know its gonna be a happy new year for you :)
Logged
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline MaryC

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  • Posts: 117
  • Life is not a sprint; it's a marathon.
Re: Harvoni and HCC connection?
« Reply #27 on: January 07, 2016, 06:37:23 pm »
Deb,
So happy for you!! You will get through this!  Keep the faith and maintain your strength and stamina as best as you can.  It is important to be kind and take care of yourself now. 
Mary
Logged
GT 3a
Dx'd 4/15 not known when contracted
Labs 7/15:
-VL 537,000
-AST 32
-ALT 41
-Fibrosis score 0.46 (F1-F2)
Started tx 9/17/2015 with Daklinza + Sovaldi
6/6/16: 24 week EOT SVR!  Cured!

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Harvoni and HCC connection?
« Reply #28 on: January 07, 2016, 08:20:22 pm »
Great news - so relieved to read this!
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Harvoni and HCC connection?
« Reply #29 on: January 07, 2016, 08:50:19 pm »
OH Deb

That is so great!

You have been in my thoughts every day. I have been holding my breath waiting to hear how you are doing.

we are all pulling for you

:)
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!
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