Olysio + Sovaldi 8 weeks in; big viral load reduction but no SVR is this NORMAL?

[amocuatli]

So my Doctor called and said that the hoped for SVR was not acheived in 8 weeks; that this happens and that we can be hopeful for it in the 12 weeks bloodtest.  Then I remembered reading that in the Cosmos study like sixty something percent of the people didn't get a response by week 8--but went on to have a viral response after 12 weeks.
Is anyone else having the same experience; also does anyone else remember reading this and where it could be found.
Worried (a little) in Lovely Alabama--Amocuatli

[Mike]

Here's the link to the COSMOS study. Please remember that SVR (sustained virological response) refers to the period after you finish or discontinue treatment - it does not refer to any period while you're on treatment. So an SVR4 means that the virus remains undetectable 4 weeks after the date treatment was completed.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&uact=8&ved=0CCUQFjAB&url=http%3A%2F%2Fwww.jnj.com%2Fnews%2Fall%2FFinal-Data-from-the-Phase-2-COSMOS-Study-of-Janssens-Once-Daily-Simeprevir-in-Combination-with-Sofosbuvir-Presented-at-The-International-Liver-Congress-2014-of-the-European-Association-for-the-Study-of-the-Liver-EASL&ei=yCG_U5LIB8KRyASj3YDADQ&usg=AFQjCNEv_DrOIvWK6qW0xps6VvNK4B2X1g&bvm=bv.70810081,d.aWw

Best wishes, Mike

[mitpabon]

Mike,

Check out the following:
http://www.healingwell.com/community/default.aspx?f=25&m=3064490

http://forums.hepmag.com/index.php?topic=1186.new#new

[amocuatli]

Yep, not an SVR, an RVR and I must have really been a mess because I also made a mistake on the number of weeks this is 8 weeks, not 12. I started on June 2! here's what it says about this topic in the study you sent me the link for THANKs btw:  Rapid virologic response (RVR, defined as undetectable HCV RNA at Week 4 of treatment) was not found to be predictive of achieving SVR. In patients receiving simeprevir and sofosbuvir alone for 12 weeks, 93 percent achieved SVR, while 57 percent achieved RVR