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Author Topic: Olysio + Sovaldi 8 weeks in; big viral load reduction but no SVR is this NORMAL?  (Read 8169 times)

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Offline amocuatli

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  • Posts: 43
So my Doctor called and said that the hoped for SVR was not acheived in 8 weeks; that this happens and that we can be hopeful for it in the 12 weeks bloodtest.  Then I remembered reading that in the Cosmos study like sixty something percent of the people didn't get a response by week 8--but went on to have a viral response after 12 weeks.
Is anyone else having the same experience; also does anyone else remember reading this and where it could be found.
Worried (a little) in Lovely Alabama--Amocuatli

Offline Mike

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Here's the link to the COSMOS study. Please remember that SVR (sustained virological response) refers to the period after you finish or discontinue treatment - it does not refer to any period while you're on treatment. So an SVR4 means that the virus remains undetectable 4 weeks after the date treatment was completed.


Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline mitpabon

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« Last Edit: July 11, 2014, 12:03:23 am by mitpabon »

Offline amocuatli

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Yep, not an SVR, an RVR and I must have really been a mess because I also made a mistake on the number of weeks this is 8 weeks, not 12. I started on June 2! here's what it says about this topic in the study you sent me the link for THANKs btw:  Rapid virologic response (RVR, defined as undetectable HCV RNA at Week 4 of treatment) was not found to be predictive of achieving SVR. In patients receiving simeprevir and sofosbuvir alone for 12 weeks, 93 percent achieved SVR, while 57 percent achieved RVR


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