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Author Topic: sam-e  (Read 17225 times)

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Offline rockee

  • Member
  • Posts: 10
sam-e
« on: April 23, 2015, 12:52:41 pm »
Hi all going to start Harvoni soon and want to know if it is okay to be taking sam-e with it.  Any thoughts would be great.   Thanks so much

Offline BubbaT

  • Member
  • Posts: 267
Re: sam-e
« Reply #1 on: April 23, 2015, 01:00:54 pm »
Hi rock,

You should ask your Dr.! He will be the best source..
 in my opinion I would not take it... Since, I  started 8 weeks ago I haven't taken nothing minus 1 Tylenol, I'm on week 8,  undetected at week 4....

Welcome to the forum..
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: sam-e
« Reply #2 on: April 23, 2015, 03:01:05 pm »
I wouldn't...Harvoni does interact with a number of substances, and most of the supplements are yet to be clinically evaluated. Since SAMe may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system, that was enough info for me to not use it. I stopped most supplements when I was on treatment.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline rockee

  • Member
  • Posts: 10
Re: sam-e
« Reply #3 on: April 24, 2015, 11:38:37 am »
Thanks, just hoping to avoid any added depression that harvonii may trigger. Maybe it won't trigger,perhaps ribavirin is the one that does?

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: sam-e
« Reply #4 on: April 24, 2015, 11:54:21 am »
Anxiety tends to be a bigger issue than depression. One thing to think about, if you do take SAMe, space it at least 4 hours from your Harvoni dose.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline rockee

  • Member
  • Posts: 10
Re: sam-e
« Reply #5 on: April 24, 2015, 12:32:41 pm »
thanks again for that.  I have only been on sam-e for three weeks, I will go off of it slowly and hope for the best.  If I decide to go back on I will space it like you mentioned.

Offline opaleye

  • Member
  • Posts: 67
Re: sam-e
« Reply #6 on: April 30, 2015, 10:47:12 am »
Hi rockee,

I stopped just about all my supplements even though they were approved by my doctor (including milk thistle which I had been on for 17 years) except for calcium/magnesium and SAM-e because I was concerned about insomnia and depression. I had read that SAMe actually increased the response to interferon treatments. (http://www.gastrojournal.org/article/S0016-5085(10)01326-0/abstract) Of course Harvoni and interferon treatments are based on completely different mechanisms, but it seems logical that SAMe could support my body's natural interferon in a similar way.

My 8-week treatment was completed on 4/29/15. The 4 week labs into treatment were VL < 15 detected which is considered successful response. (In fact, the nurse delivering the results over the phone said it was "not detected".)

I have gotten depressed a few times during treatment. I believe it would have been much worse if I hadn't taken SAMe. I didn't intentionally think about the 4 hour spacing -- Thanks Lucinda! -- but I did space them out taking Harvoni at 5:30 PM and SAMe around 11:00 PM.

Hope this helps!

~ Opaleye
1982 Dx Non-A Non-B infection
1998 Dx HVC genotype 1a; VL < 1 Million; Liver Biopsy F0 A0
2006 Liver Biopsy F1 A1
2015 Harvoni Tx 8 wks: 15 wks post-EOT: VL ~670,000 -- Relapsed
2018 Mavyret Tx 16 wks: VL 90 at 12 wks, dr stopped Tx per VL detected, severe fatigue, dizziness (a month later got pacemaker for bradycardia)
2021 Liver biopsy: No fibrosis
2023-12-14 Started Vosevi: Hemocrit 48.8, platlets 133, ALP 141, AST 91, ALT 75, VL 1824750
2024-03-14 EOT Not Detected!

Offline rockee

  • Member
  • Posts: 10
Re: sam-e
« Reply #7 on: April 30, 2015, 01:07:36 pm »
excellent information !!!!! thank you sooo much.  I wanted to stay on my magnesium as well as sam-e... Congratulations on your completion of the Harvoni treatment and success.  I too will be on 8 weeks program starting today... P.S. (please google the calcium lie you may find it interesting since you are taking calcium sups)

best Rockee

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: sam-e
« Reply #8 on: April 30, 2015, 02:46:23 pm »
Hi guys
What kind of Magnesium do you take?  I wanted to start taking Magnesium but got overwhelmed when trying to choose.
« Last Edit: May 01, 2015, 09:39:09 am by Debula »
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline rockee

  • Member
  • Posts: 10
Re: sam-e
« Reply #9 on: May 01, 2015, 01:13:01 am »
Magnesium citrate is best I think.

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: sam-e
« Reply #10 on: May 01, 2015, 09:39:45 am »
Thank you rocke
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline opaleye

  • Member
  • Posts: 67
Re: sam-e
« Reply #11 on: May 03, 2015, 04:06:02 pm »
The Cal/Mag I take is also Citrate. Thanks, rocke for the advice on Calcium :)  I just ran out and haven't replaced it yet. I think I have some straight Mag Citrate somewhere... 

~Opaleye
1982 Dx Non-A Non-B infection
1998 Dx HVC genotype 1a; VL < 1 Million; Liver Biopsy F0 A0
2006 Liver Biopsy F1 A1
2015 Harvoni Tx 8 wks: 15 wks post-EOT: VL ~670,000 -- Relapsed
2018 Mavyret Tx 16 wks: VL 90 at 12 wks, dr stopped Tx per VL detected, severe fatigue, dizziness (a month later got pacemaker for bradycardia)
2021 Liver biopsy: No fibrosis
2023-12-14 Started Vosevi: Hemocrit 48.8, platlets 133, ALP 141, AST 91, ALT 75, VL 1824750
2024-03-14 EOT Not Detected!

Offline chino1969

  • Member
  • Posts: 117
Re: sam-e
« Reply #12 on: May 07, 2015, 02:48:22 pm »
How about a Vitamin B Complex?

Offline opaleye

  • Member
  • Posts: 67
Re: sam-e
« Reply #13 on: May 07, 2015, 08:42:28 pm »
I take B-Complex occasionally for a little energy boost. Ideally, the dosage of each B vitamin should be balanced, not all the same, like the 50 mg or 100 mg formulas. (Even though I know better, what's in my cabinet is an across-the-board 100 mg formula.) I look for the B-12 to be methylcobalamin instead of the commonly found (and cheaper) cyanocobalamin.

This advice on cyanocobalamin versus methylcobalamin isn't a scholarly article, but at least the author is a doctor: http://www.dadamo.com/B2blogs/blogs/index.php/2004/02/07/cyanocobalamin-versus-methylcobalamin?blog=27

There also a connection between methylcobalamin and SAMe.

Effect of cobalamin derivatives on in vitro enzymatic DNA methylation: methylcobalamin can act as a methyl donor http://www.ncbi.nlm.nih.gov/pubmed/1868079

Hope this helps!

~Opaleye
1982 Dx Non-A Non-B infection
1998 Dx HVC genotype 1a; VL < 1 Million; Liver Biopsy F0 A0
2006 Liver Biopsy F1 A1
2015 Harvoni Tx 8 wks: 15 wks post-EOT: VL ~670,000 -- Relapsed
2018 Mavyret Tx 16 wks: VL 90 at 12 wks, dr stopped Tx per VL detected, severe fatigue, dizziness (a month later got pacemaker for bradycardia)
2021 Liver biopsy: No fibrosis
2023-12-14 Started Vosevi: Hemocrit 48.8, platlets 133, ALP 141, AST 91, ALT 75, VL 1824750
2024-03-14 EOT Not Detected!

 


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