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Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE!  (Read 660252 times)

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Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
 Coastal Girl, Looking good if I do say so myself. Always happy to see more and more graduates getting their SVR12 diplomas! 8) 8) 8) 8) 8) 8) 8) 8) Onward and forward to SVR24 everyone! Damn it sure does look extremely bright for the future :) :) :) :D :D :D ;D ;D ;D

 LIFE IS TO SHORT TO BE SERIOUS ALL OF THE TIME. SO IF YOU CAN'T LAUGH AT YOURSELF, CALL ME! I'LL LAUGH AT YOU! ;) ;) ;) ;)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Coastal girl,

Nice!!!! Blessings moving forward.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Congratulations CG
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
All this good news, I hope we can share it. I am looking for people to submit their Hep Stories. Everyone has a story, and you don't need to be a good writer to tell it. We'll help with the story. Submit stories to: http://www.hepmag.com/hep_stories.shtml
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline AussieRosa

  • Member
  • Posts: 226
Congratulations, Coastal Girl! What wonderful news.
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline coastal girl

  • Member
  • Posts: 36
Thanks All,
I'm a Happy Happy girl!!!!
8/6/15
1a, shear wave elastography F4
ast-114 alt-80,
viral load 5,941,282

Start Harvoni 9/3/15
ast-131 ast-97, viral load 12,997,415

9/29/15 4 week labs VL 64
ast 34 alt 17
11/25/15  12 wk EOT Undetected!
AST 29 ALT 17  Albumin 3.8 Bil .06

12 week PostTX UNDETECTED!!!
AST 33 ALT 20  Bil. 0.9 Albumin 3.9

25 week Post Tx  UNDETECTED

Offline jakas

  • Member
  • Posts: 265
Congrats I hope to be able to post here good news if I have it soon :)
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline lin44

  • Member
  • Posts: 15
Hello Friends  MY FINAL STATS CURED 8 weeks HARVONI
Infected age 21 1982 treatment naïve until HARVONI
genotype 1a,(CC)
f0-f1
necro a2-3
vl 1million          undetected after 3 weeks sept22 2015 & 6weeks on tx,Oct 22,2015
ast 90                50 in 2004  NOW 23  lowest since im 21
alt 100               49 in 2004   NOW  21 lowest
EOT
UNDETECTED  4weeks liver enzymes 15/16
UNDETECTED 12 Weeks        16/18
UNDETECTED 15 weeks  liver enzymes 13/15

Offline gnatcatcher

  • Member
  • Posts: 1,372
Exciting -- CONGRATULATIONS! So glad you could be cured while still f0-f1.What a fully healthy life you now have ahead of you!
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline lin44

  • Member
  • Posts: 15
Thank you! Knowing I had HEPATITIS my whole life helped me manage and watch my health and fitness,linda

Offline concerned father

  • Member
  • Posts: 79
Congrats lin44.

Offline Camper

  • Member
  • Posts: 14
  lin44 that is good news only 8 weeks of Harvoni and cured. Taking good care of your health makes a big difference in the condition of your liver. What you eat and what you put on your skin passes through your liver in some way. A representative from Schering Plough at a support group meeting several years back said that research study found that antiperspirant greatly affects the liver in negative ways. My doctor about 25 years ago told me I needed to be careful what I eat no more fast foods to eat natural preferably organic to reduce stress on liver. The advice made a big difference in the condition of my liver today.
« Last Edit: February 28, 2016, 07:10:09 am by Camper »

Offline Scoutdoy

  • Member
  • Posts: 452
Congrats coastal, that's fantastic



Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline lin44

  • Member
  • Posts: 15
camper did you get sick when you were infected like I was??

Offline Camper

  • Member
  • Posts: 14
  I had discomfort and tenderness in my abdominal area and would get very fatigued and would need to get a lot of rest. I took milk thistle every day for about 20 years I think that helped. Very happy to have been cured and each week I feel a little better and stronger. My doctor told me my liver would never return to a normal liver but would heal itself to a point just how much time will tell. The biggest thing I have been noticing is how clear my thoughts are now I can remember numbers and how words are spelled much better. So thankful I have lived long enough and others that a cure has been found and feel very sorry for those that did not live long enough to be cured. 

Offline Cute

  • Member
  • Posts: 34
Dear Friends,

I would like to share some news about my mother's post-treatment developments. Some of you know that my mother had 3m Harvoni treatment. She achieved EOT and SVR12. But then bad luck happened, SVR24 was positive with low viral replication. We disappointed because of relapse. Moreover, her all liver tests elevated. ALT,AST, GGT were very high, out of the normal range. All of those happened in December,2015

Beginning of the March, mother was tested for blood work. The results are shocked me. All liver tests and blood work are in the normal range. ALT, AST, GGT, Albumin and platelets are in the good range. In other words, they have returned back to normal.

 Mother has only complain: abdominal ascities.

Our doctor says mother should have new viral test (PCR). He says, Harvoni is quite new drug and even doctors don't know how it affects virus and human immune system. Harvoni changes virus RNA and makes it fragile. Even virus survives after Harvoni, it is not so strong as before. While virus is infirm, immune system gets opportunity kill it once and for all.
He says we have a chance that virus is gone or at least very weak.

Now mother and me hope for a miracle. We will go for PCR test at the end of March. We are so tried and so hoping to hear good news.

What do you think? Is it possible that virus with low replication 6 month after Harvoni treatment is gone then?

notes: 3m Harvoni treatment; EOT negative and SVR12 neqative. SVR24 low virus replication and bad liver tests. after 32 weak of treatment all liver tests and blood work are in the norma range.

Please share you opinions.
I kiss all of you and wish good and strong health. Hope all members will survive and slay the dragon!
Thanks
 

Offline jakas

  • Member
  • Posts: 265
Hoping for the best with her new PCR test
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Scoutdoy

  • Member
  • Posts: 452
Wow, don't really know what to say about that one. I am sorry to hear of the relapse, that is so unusual to have a 12 week EOT that is negative and then a 24 week that shows relapse. I would find out from Gilead what the statistics and the protocol is for re treatment. Specifically for Genotype 3, if I read your statement correctly. Please let us know what you find out, and good luck and prayers for your mother.


Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline Cute

  • Member
  • Posts: 34
Wow, don't really know what to say about that one. I am sorry to hear of the relapse, that is so unusual to have a 12 week EOT that is negative and then a 24 week that shows relapse. I would find out from Gilead what the statistics and the protocol is for re treatment. Specifically for Genotype 3, if I read your statement correctly. Please let us know what you find out, and good luck and prayers for your mother.


Scout

Thanks a lot. She is Genotype 1b.

Offline Baxter

  • Member
  • Posts: 87
I'd be curious to know if anyone's kept an updated running total of the people posting here. I'm starting 12 weeks tomorrow, and really wondering how closely the clinical trial numbers correlate to real world results.

Thanks to everyone who's contributed to this; it's impossible to put into words how much value this board has had for me already.
Gen 1a
Inf. '85
Dx '98
'98 biopsy - Grade 2, Stage 2, VL 7 mil
'01 biopsy - Grade 1, Stage 1, VL 1.5 mil
'08 biopsy - Grade 1, Stage 1, VL 3.5 mil
'12 biopsy - Grade 1, Stage 1, VL 3.5 mil
'16 Fibrosure - Grade I, Stage 3, VL 6.4 mil and 4.8 mil
4/23/16 - ALT 89, AST 50, pltlts 120k. Started 12 wks Harvoni
4/31/16 - ALT 30, AST 21, pltlts 125k
4/14/16 - ALT 25, AST 16, pltlts 126k, VL 69
5/11/16 - ALT 28, AST 21, pltlts 140k,VL <15
6/7/16 -EOT, UNDETECTED!
9/7/16 - cured. Low Stage 2 fibrosis

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,542
  • Get tested, get treated, get cured, fight Hep c!
Hi Baxter
That was kind of the original purpose of this thread

A couple of pages back I found this post by Mugwump 12/11/15 which links to some other post stats but not really a statistical analysis of SVR vs relapse just SVR data as posted by members there have been many

https://forums.hepmag.com/index.php?topic=2665.msg35687#msg35687
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,542
  • Get tested, get treated, get cured, fight Hep c!
Also found this article from 66th Annual Meeting of the American Association for the
Study of Liver Diseases Boston, MA Nov 13-17 2015

Summary from AASLD 2015 for Hepatitis C Beyond 95% SVR cure rates: still room for improvement?

http://www.natap.org/2015/AASLD/AASLD_165.htm
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline mdj

  • Member
  • Posts: 5
1. 4wk EOT VL: Undetectected
2. 8wk EOT VL: Undetectected
3. 12wk EOT VL: Undetectected
4. 36wk (9 months) EOT VL: Undetectected
5. Treatment duration-12 weeks
6. tx naive
7. Genotype 1a
8.  fibrosis status--F3-F4 (Mar 2015)
9. Initial VL (2.1million/Oct 2014; retest 700,000/March 2015)
10. AST (SGOT); 22.  ALT (SGPT); 20.  First time these numbers have been in the normal range in over 30 years (test results after 12 wk EOT).

Good luck to all!!!  Will check back again.

Offline gnatcatcher

  • Member
  • Posts: 1,372
SVR36 -- EXCELLENT! Yes, please keep us posted on SVR48 or 52 or whatever.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
MDJ -- WOW!!!! I just hope to be able to post the same some day, in the near future.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline concerned father

  • Member
  • Posts: 79
Woo Hoo another success story. :)

Offline jakas

  • Member
  • Posts: 265
4 wks E.O.T. V/L UNDETECTED  :D
Now its some progress for  me
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline gnatcatcher

  • Member
  • Posts: 1,372
Glad to hear your good news, jakas.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Coolio Jakas!!!

4wk labs tell it.  You got this.  Conga line worthy.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,542
  • Get tested, get treated, get cured, fight Hep c!
Alright jakas WTG

Conga line getting ready!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
 The dragons are dropping like flies these days! Good News Jakas!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
"I bet there are some really great HEP stories here among all these dead dragons," said the desperate person looking for some HEP stories in order to share hope with others...https://www.hepmag.com/category/hep-stories
BTW, today's story in incredible: https://www.hepmag.com/article/jm
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Coach Mike

  • Member
  • Posts: 292
    • Affordable Hepatitis C Treatment
Well,
My 12 week tests came back-Undetected.
The virus was basically wiped out by Mesochem sofosbuvir and ledipasvir the first 4 weeks.  A 12 week tx can currently can be imported in 3-5 days for $860.00- no prescription required.
Incepta's Twinvir for $1000.00.
Dr. James Freeman is presenting his REDEMPTION generic clinical trial results next week at EASL.  The findings are stellar. Generic prescriptions may become easier to get in the U.S. after those results are published.
Gilead is interested is selling and making money.  The only reason they would care about relapse is that it might affect their sales.
Sad but true.
CM
Genotype 1a, Biopsy:11/2014: F-1, Tx Naive
Fibrosure, 7/20/15: F-1-2
Pre tx v/l: 1,600,000, ALT: 75, AST: 48
Started generic sofosbuvir & ledipasvir: 10/23/15
4 wk labs: 11/19/15, ALT: 21, AST: 16, V/L:  UND
Started 8 week Harvoni tx: 11/20/15
8 wk labs, 12/15/15, ALT: 15, AST: 13, V/L: UND
4/11/16 12 week EOT-Undetected
7/5/16 SVR 24

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Coach Mike -- FANTASTIC NEWS!!  I've been watching for your post on the 12 week results; very glad to hear this.  What a battle you went thru to get to this point! Can't wait to see what new info comes out of the EASL meeting, should be very interesting. This is a stellar year for HCV treatment, finally.

I have  blood work next week and am keeping fingers crossed for the magic word "UD" this time.  Again, so happy to hear your news!!!  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Looking good Jakas - You are well on your way to SVR12 :)
Congrats Coach Mike, I am so pleased for you. :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline HazelAustralia

  • Member
  • Posts: 178
Great news Jakas! Good on you.

Coach Mike, congratulations - one small step for man, a giant step for man(&woman)kind!
Female age 53
Australia
Contracted in the 1980's
Genotype 1A
VL 314k

Started treatment with Veikira Pak and Ribaviron on Thursday 17th December 2015
NOT DETECTED, End of Treatment, 16th March 2016

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Coach mike,

I have often thought about you through this waiting period.  All one needs to do is read through all of the harvoni posts to get the idea that waiting for labs can be a bit stressful.  For you, however, and others forced to go the generic route, there must have been an added "guinea pig" stress element.  You got the meds from over seas for less that a fraction of the cost of Harvoni.  It may turn out that that is the sensible way to go.

Congrats and thanks for your contributions to this forum and giving hope to those unable to acquire the drugs through the conventional route.

HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline The Terminator

  • Member
  • Posts: 21
12week after tx no virus
starting vl 211,000
8weeks harvoni
no prior tx
24 week blood test july-2016

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Excellent news!!  I hope to be not too far behind you in my quest for SVR.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline concerned father

  • Member
  • Posts: 79
Awesome another win for the good guys.

Offline kimlav

  • Member
  • Posts: 24
Hello everyone,

It is fantastic to see all the undetecteds going on around here. Who could have ever believed it after so many waited for so long. I am forever indebted to those who endured the torture of interferon and helped pave the way to today's DAA's. Thank you Michael Sofia.

1. 4.5 wk EOT - vl UNDETECTED
2. 8 weeks Harvoni
3. Tx naive
4. 1a
5. F0
6. 657,000

Now I wait for the 12 week vl but I am feeling optimistic.

Kim
52 year old female
Geno 1a
Contracted in the 80's
Tx naive
vl 657,000 in Nov/15
No liver damage
ALT prior to tx: 107, 91 - 41 at 2 wks, 38 at 4 wks
AST prior to tx: 59,72 - 45 at 2 wks, 37 at 4 wks
started 8 wks Harvoni on Jan 21/16
EOT vl <12 detected
4.5 wk EOT vl - target not detected! RNA Not detected!
12 wk EOT vl - target not detected! (Will never get tired of typing that)
24 wk EOT vl -  not detected

Offline Bob V

  • Member
  • Posts: 231
I posted this on the 24wk post tx thread too.

Hi everyone
It's been a long time since I've posted but I do check in from time to time. Most of the old names are gone but Lynn and Eric good to see you guys still posting.

Anyway I just got my 58wk post tx lab results, UND!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Katie

  • Member
  • Posts: 784
YAY Bob!  Me too!

Just wanted everyone to know, I did get my requested 12 month post treatment blood work done when I had an extensive panel completed.  Got the results and every single test was perfect from thyroid to cholesterol from liver panels to tumor marker and of course my VL is UNDETECTED.

Here is a wish for all of you to conquer the BEAST and have a healthy happy life.

Enjoy your summer and the very best to all of you!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Bob V

  • Member
  • Posts: 231
Hi Katie
Great news!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Wonderful news Katie!!!
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline jakas

  • Member
  • Posts: 265
Well done Katie. God Bless ! :)
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline concerned father

  • Member
  • Posts: 79
So nice to see all the success stories, kept them coming.

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Katie, fantastic news!!  Did you have to request that 1 year test or was it recommended by your doctor? Thanks, FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Katie

  • Member
  • Posts: 784
Katie, fantastic news!!  Did you have to request that 1 year test or was it recommended by your doctor? Thanks, FT

I actually requested it from my doctor when I was getting my annual blood work done.  Nothing was challenged and I wanted the confirmation that all previous tests were accurate.  I feel confident now, that I am clear and feel that chapter of my life is closed.

Thanks everyone for the responses....... I love how this forum shares the Joy and the Sadness and gives support no matter what.  You all have helped me through a difficult time and I am here for you too!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline concerned father

  • Member
  • Posts: 79
Katie, fantastic news!!  Did you have to request that 1 year test or was it recommended by your doctor? Thanks, FT

My daughter's doctor actually scheduled another test for one year after she achieved SVR.

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Thanks Katie and Concerned Father, I just wondered, as my hepatologist gave a bit of a vague answer this week on if they would be doing any tests after SVR12 or they would let my GP f/u on that. I, too, am sure I will want that RNA test at 1 year and maybe even 2! FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline Bob V

  • Member
  • Posts: 231
concerned father
I remember you wanting to get your daughter on Harvoni. Sounds like great news for you/her.

Future Thinker
I replied to your post the other post tx thread.
« Last Edit: April 30, 2016, 07:28:28 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline concerned father

  • Member
  • Posts: 79
The greatest news of my life Bob :)

Offline Pablo

  • Member
  • Posts: 16
4wk UND
12wk svr12 UND
12ks of harvoni and ribavarin
2 failed prev tx
Gen 1
F4

Offline Bob V

  • Member
  • Posts: 231
Pablo
YAY! Congrats:)
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Pablo, I'm so glad "the third time's the charm." Victory!
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,542
  • Get tested, get treated, get cured, fight Hep c!
Si se puede Pablo!

Congrats!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline concerned father

  • Member
  • Posts: 79
Great news Pablo. :)

Offline jakas

  • Member
  • Posts: 265
@ Pablo well done !! Super news.

Is this still the case ?:
Stat is for Harvoni 98.5% predictive at 4 weeks SVR  and 99.8% at 12 weeks
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Mugwump

  • Member
  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
@ Pablo well done !! Super news.

Is this still the case ?:
Stat is for Harvoni 98.5% predictive at 4 weeks SVR  and 99.8% at 12 weeks
We have not seen anything to contradict this except we saw a propensity of shortened 8 week treatment relapses for those who had only minor liver damage but a good correlation for those who did not have any liver damage clearing and achieving SVR cured.


Also it seems that shortening the treatment to 12 weeks if you have cirrhosis is also not a good idea as we have also seen those who were shortened to 12 weeks relapse. But as others have stated most likely those who relapsed were more likely to post this unfortunate situation whereas many other forum members who did clear have not posted to this thread.


We can say that the clinical decision to shorten anyone to 8 weeks if there are any signs of liver damage whatsoever is questionable.


How many of the individuals on this thread that have RAVs is totally unknown and we should not forget that up until last year the RAVs that make Harvoni and other DAAs less effective were an unknown factor.


ABOUT THE POSSIBLE DANGERS OF SHORTENING TREATMENT:


It is only sensible that shortening of treatment might over time also have the adverse effect of creating new RAVs. We are just starting to see how this disease has managed to be so elusive and the study of how it manages to survive DAAs is really important.


Here is hoping that RAVS are only temporary switches in the RNA sequence that change and that DAAs will be effective for retreatments. I have long thought that the mechanism that HCV uses to trick the immune system might be like a clock that cycles through a sequence of variants. Essentially that HCV in itself is a diabolical polymorphic time bomb not an RNA sequence set structure.


Here is hoping that I am correct.


Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline J.R.

  • Member
  • Posts: 38
8 week tx of Harvoni. Just received 4 week EOT......undetected!!!
Contracted-mid 80s
Diagnosed- 2008
Treatment Naive
AST-34 (01-16 test)
ALT- 71 (01-16 test)
VL-4.1 mil (01-16 test)
GT- 1a
Fibrosure-0.33 (F1-F2)
Harvoni tx start 2/20/16
HCV RNA Quant- undetected (3-7-16)
AST-16. ALT-30 (3-7-16)
AST-19. ALT-39 (3-21-16)
HCV RNA  Quant- undetected (3-21-16)
AST-17, ALT-38 (4-1-16)
HCV RNA- Undetected (4-1-16)

EOT-4-15-16
HCV  RNA- UNDETECTED
AST- 21  ALT- 42

4 wk EOT (5-13-16)
HCV- undetected
AST-17  ALT- 36

Offline concerned father

  • Member
  • Posts: 79
Way to go, in 8 weeks you will get confirmation that you are cured.  Congrats.

Offline concerned father

  • Member
  • Posts: 79
HEP C will not kill JR :)

Offline Bob V

  • Member
  • Posts: 231
JR
Congrats!!!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline malou

  • Member
  • Posts: 57
I just had a 6 week post treatment result iof undetected.  Harvoni and Twinvir are chemically identical.  All of my other info is in my profile.
HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Congrats Malou! That's a great feeling! :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline malou

  • Member
  • Posts: 57
Thanks Kim, particularly since I had no side effects.  Interferon was a nightmare for me that I will never forget.  Twinvir was a breeze and if I had the 'harvoni' high, I loved it!  I am very grateful that this drug was developed.  ML
HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline Determined

  • Member
  • Posts: 44
Wow FT.  Good work going straight to the source and rocking it.

Offline Bob V

  • Member
  • Posts: 231
malou
Congrats!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline malou

  • Member
  • Posts: 57
Thank you Bob V
HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Malou, fantastic news! Great to hear about success with generics. FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline beflat10r

  • Member
  • Posts: 21
I am surprised that nobody has posted results in almost a week!  I thought a lot of people came off treatment mid to late march.
It's too complicated to "cut and paste this and that" .. "don't do this, don't do that" "Follow these rules"

That's why I haven't posted my, as of today, clean bill of liver health.
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline Bob V

  • Member
  • Posts: 231
 beflat10r

Congrats!!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline beflat10r

  • Member
  • Posts: 21
..Back at ya!!!!!
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline Hepaway

  • Member
  • Posts: 3
1. 4wk - 12 wk EOT VL status
2. Treatment duration
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)

1. Undetected at 4-12 EOT
2. 8 week treatment harvoni
3. Tx naive
4. 1b
5. F0
6. VL 350,000 Initially diagnosed in 2004, infected in 1976
CURED

Offline beflat10r

  • Member
  • Posts: 21
yay!!!!!!!!!!
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline concerned father

  • Member
  • Posts: 79
I love these success stories, keep them coming.

Offline Bob V

  • Member
  • Posts: 231
Hepaway

Congrats!!!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline brie41

  • Member
  • Posts: 191
Congrats Hepaway!  Never gets old seeing it or saying it!  Brie
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline badbradley

  • Member
  • Posts: 294
Hello     Its been a while        Treatment Update
              ANOTHER DRAGON SLAIN!!
 I have received SVR 12 status after a 12wk regimen of Harvoni / Ribavirin. First treatment was Sovaldi / Olysio 12wks. UD at wks 4, 12, relapsed 12wks post.
   Initially I was denied Harvoni but approved for VP.That particular regimen was Not Recommended by AASLD Guidelines due to cross resistance from previous treatment.
      Fast forward 7 mths, I was approved for 12wks Harvoni/Ribavirin with some help from a forum friend and a person at Express Scripts who was extremely helpful in monitoring my appeal and making contacts, etc.
      I began treatment Dec. 6, '15.  Naturally after failng a DAA regimen, my expectations were a bit simmered. The 12wk regimen of Harvoni/Ribavirin was a recommendation based on limited data.
     Treatment went fairly smooth, much like the Sov/Oly treatment with the added joys of riba rage and awful itching. I was UD at wks 4 & 12, other labs much the same as first treatment.
     I began experiencing occasional lower right and left quadrant aches and pains. I have seen other patients reporting similar experiences so I wasn't overly concerned. A short time later I learned that the recommended regimen for S/O relapses had been revised from 12 to 24wks. This newly revised recommendation had been implemented 3 days before end of treatment, however, I was not to learn of it until 2wks post treatment.  I was quite anxious about this new information as you can imagine and I soon began experiencing generalised abdominal discomfort, digestive issues (loose stool), some  muscle and joint aches and pains which at times awakened me.
    I was about 99% sure the virus had returned so had Doc order enzyme test. To my surprise,  ALT dropped from 21 EOT to 16 3wks post.  AST remained unchanged at 17. I was somewhat encouraged by these results but still concerned, naturally. Digestive and muscle & joint pains continued intermittently. At 12wk post treatment lab time I was almost sure the virus had not been cleared. Actually I went in a few days early. Anyways, I was extremely relieved to see Not Detected.
    What a rollercoaster ride this has been.
   I am working on De-Stressing and am feeling a bit better. It feels good to say I USED to have Hepatitis C.
   I have learned much browsing these forums. Thank you to all who contribute.
Good luck to everyone seeking treatment and those on treatment.
                                                                               Brad
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
CONGRATS ON YOUR SVR12 BRAD !!!

And yes, it DOES feel good to say "I had Hepatitis C."  8)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline badbradley

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Hi Kim,    Thank you very much. I've waited a long time to be able to post that. I hope your post treatment struggles resolve soon. I am struggling a little bit more than the first treatment with S/O but I think it is stress related. Stay healthy and I hope you can enjoy your summer. Take care Kim
                                                              Brad
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline beflat10r

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  • Posts: 21
YAY!!!!
I'm gonna use that "I USED to have Hep C"!!!
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline Lynn K

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  • Member
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  • Get tested, get treated, get cured, fight Hep c!
All right Brad that is fantastic news! Welcome to the "I used to have hep c" club!

I still having trouble getting my head around the concept 1 year post but it's all good!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Mugwump

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  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
Brad the best stress pill is to do something that you have put on the back burner because of HCV. Otherwise every little ache and pain will make you worry.

I am not at all saying that some of us did not experience a very hard ride getting rid of the beast but I know that it is time to smell the roses, cow shit and everyday living that we have forgotten how to enjoy!

It is fantastic hearing you cleared without a hitch on 12 weeks of Harvoni and Riba. I am really lucky that I did not go through another relapse which is what might have occurred if I went on S and O in 2013 not waited for a better alternative to be approved in Canada.

Cheers
Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Hi Kim,    Thank you very much. I've waited a long time to be able to post that. I hope your post treatment struggles resolve soon. I am struggling a little bit more than the first treatment with S/O but I think it is stress related. Stay healthy and I hope you can enjoy your summer. Take care Kim
                                                              Brad

Thanks Brad! I'm hanging in there! ;)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Bob V

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  • Posts: 231
Excellent news Brad!!! Congrats and enjoy your new HepC status.
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline badbradley

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Thank you  bflat10R,  Lynn K,  Mugwump,  BobV,
         I haven't fully digested this news yet. Half of my relief is knowing I wont have to research or battle to get meds anymore.
   I would like to point out that my on treatment and post treatment physical ailments were likely stress induced. I will say I wasn't crazy about the Ribavirin.
    Mugwump, Yes , you're right. It is time to smell all those wonderful smells the world has to offer!
   Have a great Memorial Day weekend.
                                             Brad
                                                                                         
                                                           
   
     
« Last Edit: May 27, 2016, 11:54:45 pm by badbradley »
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Hey Brad...I am thrilled for you.

What an ordeal.  I know the feeling all to well...thinking relaps.  However, in your case after failing a modern drug, the frustration and fear must have been unsufferable.  Peace now my friend...that bitch is toast!
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Philadelphia

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  • It only looks like I know what I'm doing
Hey, SVR12! That's the sort of numbers we like Congrats Brad! :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline FutureThinker

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  • Posts: 711
  • Onward and upward!
Hi all, I am finally able to post in this category! Just wanted to share my VL at 2 weeks EOT continues to be UD, so still on the right path! Next test not till August.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline concerned father

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Congrats FutureThinker great news.

Offline Determined

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  • Posts: 44
Congratulation Brad on a long and bad ass battle.  You deserve a break.

Congrats to FT, too. I knew you would do this. 

I'll post my 4 week EOT late next week. I'm getting better but still get unexpected visits from the Riba Monster.  Good thing my sword is but a metaphor.  Can wait to be in the office "had" club.

And thanks again to all for the ongoing support.

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
welcome to the ranks of the fittest FT
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Forest dweller

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  • Posts: 27
Forest dweller here..

Just got back 12  week end of tx Vl...undetected...waiting for the 24 weeks to get final test done.
1b
>6 million
Fibroscan 2-3
12 weeks Harvoni tx

4 week result- down 5 logs
8week undetected
12 week undetected...

WISH ME LUCK!!!!!!

Offline Forest dweller

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  • Posts: 27
Sorry, I shouldn't have posted yet!!!!..haven't had any post treatment tests done.....
Forest dweller

Offline badbradley

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  • Posts: 294
Congrats -  Forest dweller,  Future Thinker. Looking forward to seeing those cured posts coming shortly!
 
 Determined - Thank you and yes  it was a bit of a battle but we don't go down easy, do we?! Good luck on your SVR.

 Philidelphia and beto - Thanks and I hope to be adding lots more numbers to that SVR and Yep beto...the bitch is toast!!!

Peace all
« Last Edit: June 11, 2016, 07:22:15 am by badbradley »
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline Allen Cunningham

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  • Posts: 59
1. 8 wk EOT VL status = HCV RNA Undetected as of 6/13/16
2. 12 wks tx with Harvoni started 1/19/16
3. tx naive
4. Genotype 1b
5. F1 fibrosis status (12/15)
6. Initial VL (1.5 Million 12/15)

Offline gnatcatcher

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  • Posts: 1,372
Allen (and all who have recently joined), welcome to the SVR club!
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline jakas

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  • Posts: 265
Doc phoned SVR 12 :) next check for SVR 24
Big THANKS to all of you here for helping in the journey
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

 


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