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Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE!  (Read 530531 times)

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Offline gnatcatcher

  • Member
  • Posts: 1,372
Wonderful news, jakas!
You've helped many people here, too.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Nice Jakas...feels good don't it  :D
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline concerned father

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  • Posts: 79
Congrats to all and keep it coming I love it.

Offline kimlav

  • Member
  • Posts: 24
Congratulations to everyone slaying so many dragons of late.

I just learned yesterday that my 12 week EOT result was yes yes target not detected! SVR 12 as they say.

As you all well know, I think the wait for results was the hardest part of the 8 week Harvoni treatment. Needless to say, I burst into tears when I found out. It is still hard to believe but I am working on that.

Good luck to everyone still awaiting results or presently on treatment. Next up, SVR 24..

Kim   8)
52 year old female
Geno 1a
Contracted in the 80's
Tx naive
vl 657,000 in Nov/15
No liver damage
ALT prior to tx: 107, 91 - 41 at 2 wks, 38 at 4 wks
AST prior to tx: 59,72 - 45 at 2 wks, 37 at 4 wks
started 8 wks Harvoni on Jan 21/16
EOT vl <12 detected
4.5 wk EOT vl - target not detected! RNA Not detected!
12 wk EOT vl - target not detected! (Will never get tired of typing that)
24 wk EOT vl -  not detected

Offline gnatcatcher

  • Member
  • Posts: 1,372
and now you can write "HAD" -- congratulations, Kim!
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline jakas

  • Member
  • Posts: 265
Nice Jakas...feels good don't it  :D
YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYES !!!! :D :D
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Great news Jakas! Those are great words to hear :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Jakas and Kimlav, DOIN' THE HAPPY DANCE FOR YOU!!!!!!! Tears of joy are a very good thing and I'm sure when I get my SVR12 news, I'll be doing the same thing. All the best to you both -- the future is very bright!!  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline brie41

  • Member
  • Posts: 191
Congrats Jakas and Kimlav,

  It is wonderful news for both of you and wishing you continued success.  I am late getting my 4 week eot test done.  I must do it next week and hope to join you all!!!  Brie
Diagnosed  HCV, 1A 2006
Viral load 6 million
Ast/Alt always in the 20's
F0-F1, never changed
Treatment naive, started 8 week Harvoni 3/15/16
4 and 8 week labs undetected
6 week eot labs undetected
13 week eot UNDETECTED!

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Kimlav, I missed yours! Congratulations are most certainly in order. :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline AussieRosa

  • Member
  • Posts: 226
Congratulations, Jakas and Kimlav. So many people achieving SVR. It's always such heartening news. Thanks for letting us know.
Gt 1a
contracted 1983
Fibroscan 6.1
Treatment naive
VL 2.97M
ALT 38
AST 47
Started Viekira Pak + Ribavirin Tues 19th Jan 2016
Week 4: VL Undetected!
March 5th Ribavirin dose reduction to 800mg from 1000mg
EOT April 11th 2016. VL Not Detected
12 Weeks post EOT: SVR12. Cured with a capital C!!
6 months post EOT: Undetected :-)

Offline Lynn K

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  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Congrats to Jakas, Kimlav and to all our fellow warriors who have beat the dragon! Good luck to those still in the fight
« Last Edit: June 17, 2016, 10:15:28 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
  What is that ??? An earthquake ??? Nope , just the evergrowing Happy Hepper Conga Line snaking around the globe adding folks as is expands ever larger each and every day! :) :) :) All Hail Heplandia!!

 I HAVE SEEN BETTER DAYS , BUT I HAVE ALSO SEEN WORSE. I DON'T HAVE EVERYTHING I WANT , BUT I DO HAVE ALL THAT I NEED! I WOKE UP WITH SOME ACHES AND PAINS ,  BUT I WOKE UP! MY LIFE MAY NOT BE PERFECT , BUT I AM BLESSED.
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline concerned father

  • Member
  • Posts: 79
My daughter has just received her result of her one year after treatment results.  UNDETECTED. :)

Offline gnatcatcher

  • Member
  • Posts: 1,372
-very glad to read the good news.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline lporterrn

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  • Posts: 1,984
  • LucindaPorterRN
    • LucindaPorterRN
Wonderful news! All undetectable results are cause for celebration, but I particularly like hearing them from parents!
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Concerned Father - HAPPY DANCIN' TIME!!  I am sure you are so relieved and now all can get on with their lives.  All the best, FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline bharrisrn

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  • Posts: 10
12 week Harvoni post treatment PCR RNA on 1/1/2017 undetectable. Previous history of Interferon 1 million units three times per week in the late 90s with no response (viral load was higher than when I started). Genotopye 1A. I don't remember my initial viral load.

Offline bharrisrn

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  • Posts: 10
1. 12 wk Post EOT VL status - Undetected
2. Treatment duration - 12 wks
3. tx naive or experienced - tx experienced
4. Genotype (1a or 1b) - 1a
5. F1-F4 fibrosis status (date) - F3
6. Don't remember initial viral load

Offline gnatcatcher

  • Member
  • Posts: 1,372
bharrisrn, congratulations on reaching SVR12!

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
 Happy belated congratulations to You guys! 8) :)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Angelica

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  • Posts: 29
1. 12 wk post treatment UNDETECTED
2. Treatment duration: 8 weeks
3. tx naive or experienced: tx naive
4. Genotype (1a or 1b): 1a
5. F1-F4 fibrosis status (date):no fibrosis
« Last Edit: February 19, 2017, 05:31:41 pm by Angelica »

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Hi Angelica and welcome to the forum!

Congrats on your EOT results of not detected. :)

Is this just your EOT result? Not a big deal but the topic is "After tx(POST) 4wk or 12 wk SVR RESULTS."

If you haven't made those milestones yet please do come back and update when you get there!

Good luck on making it to SVR12 and officially cured!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Angelica

  • Member
  • Posts: 29
Hi Lynn,

thank you. I have changed my previous post and I hope it is now clearer. I am 12 weeks post treatment already.  ;D

Angelica
« Last Edit: February 19, 2017, 05:39:17 pm by Angelica »

Offline Lynn K

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  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Alright awesome sorry for my confusion and congrats on your cure!

Beautiful word cured :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline SomewhereinTX

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  • Posts: 30
1. 4wk - 12 wk EOT VL status  12 week SVR- undetected
2. Treatment duration- 8 weeks
3. tx naive or experienced- tx naive
4. Genotype (1a or 1b)- 1a
5. F1-F4 fibrosis status (date) - F2 (8.5kpa) a week and a half before beginning treatment, F3 (11.5kpa) 24 weeks after EOT
6. Initial VL (date) 1.1mil


Did not expect my fibrosis level to be increased.  I expected it to be the same or, hopefully, improved.
Received no explanation, no advice, no thoughts from my Liver Specialist upon the current Fibroscan results.
Only thing that happened was for another Fibroscan to be scheduled for one year from now.
 I requested blood work for a 24 week SVR test but was told no "because I was cured".

I feel like I was left hanging with no help and an increasing problem.  I feel like that because I was.
« Last Edit: February 19, 2017, 09:27:46 pm by SomewhereinTX »
Diagnosed November 2015
VL 1.1Mil
VL just prior to treatment beginning: 316k
F2-3
Completed 8 week Harvoni Treatment 8-18-16
Undetected after 8week EOT
Liver enzymes in normal range

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Fibroscan results in mid ranges are not that accurate.

Per the American Association for the Study of Liver Diseases (AASLD)

http://www.hcvguidelines.org/full-report/monitoring-patients-who-are-starting-hepatitis-c-treatment-are-treatment-or-have

Monitoring Patients Who Have Completed Treatment

Patients who do not achieve an SVR, because of failure of the treatment to clear, or to maintain clearance of HCV infection with relapse after treatment completion, have ongoing HCV infection and the possibility of continued liver injury and transmission. Such patients should be monitored for progressive liver disease and considered for retreatment when alternative treatments are available. Patients who have undetectable HCV RNA in the serum, when assessed by a sensitive polymerase chain reaction (PCR) assay, 12 or more weeks after completing treatment, are deemed to have achieved an SVR. In these patients, HCV-related liver injury stops, although the patients remain at risk for non-HCV-related liver disease, such as fatty liver disease or alcoholic liver disease. Patients with cirrhosis remain at risk for developing hepatocellular carcinoma.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

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  • Posts: 1,372
1. 4wk - 12 wk EOT VL status  12 week SVR- undetected
2. Treatment duration- 8 weeks
3. tx naive or experienced- tx naive
4. Genotype (1a or 1b)- 1a
5. F1-F4 fibrosis status (date) - F2 (8.5kpa) a week and a half before beginning treatment, F3 (11.5kpa) 24 weeks after EOT
6. Initial VL (date) 1.1mil

Did not expect my fibrosis level to be increased.  I expected it to be the same or, hopefully, improved.
Received no explanation, no advice, no thoughts from my Liver Specialist upon the current Fibroscan results.
Only thing that happened was for another Fibroscan to be scheduled for one year from now.
 I requested blood work for a 24 week SVR test but was told no "because I was cured".

I feel like I was left hanging with no help and an increasing problem.  I feel like that because I was.

There are a lot of possible causes for a seeming increase in kPa score, such as fasting for fewer hours this time than last, weighing more, operator error (e.g., pinging a rib instead of the liver), operator choosing a different setting....  My first time, they'd had the machine only a week or two, so they hadn't yet learned how to deal with people like me whose ribs are very close together. This third time the gal removed the pillow and had me contort like a banana so she could get the pings between my ribs, and it took her more than ten pings to get ten valid pings. She thought it very possible that my first reading had been too high because some pings might have been of a rib rather than my liver. After my first time (pre-tx), I read a study that recommended fasting for at least 4 hours (the hep doc's office always says 3 hours), so for #2 and #3 I fasted 5 hours, which may have helped lower my score. The middle time (different gal), I commented that I was rooting for a score below 12 kPa; when it came out 12.2, she said there was a setting she could adjust somewhat, that "they" didn't like her adjusting it beyond a certain point, so she adjusted that setting a little, did ten more pings, and got 11.4 kPa.

I hope this confirms what Lynn said about results in mid ranges not being that accurate. Your hepatologist's office leaves a lot to be desired in the "bedside manner" department. If I were in your shoes, I'd probably be feeling like you are. Incidentally, even though my kPa scores have decreased and I had post-tx VLs at 12, 24, and 50 weeks (all UD), my hepatologist (who just turned my liver care back to my PCP) still wants me to have VLs done at 2 and 3 years post-EOT and ultrasounds every six months unless my final FibroScan (in a year) is below 9 kPa. He doesn't expect any problems; that's just his protocol. Is there any chance you can get your PCP to order the 24-week SVR test? Odds are, you're fine, but you'd feel better knowing that the rise in kPa was a fluke.

Good luck,

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline SomewhereinTX

  • Member
  • Posts: 30
There are a lot of possible causes for a seeming increase in kPa score, such as fasting for fewer hours this time than last, weighing more, operator error (e.g., pinging a rib instead of the liver), operator choosing a different setting....  My first time, they'd had the machine only a week or two, so they hadn't yet learned how to deal with people like me whose ribs are very close together. This third time the gal removed the pillow and had me contort like a banana so she could get the pings between my ribs, and it took her more than ten pings to get ten valid pings. She thought it very possible that my first reading had been too high because some pings might have been of a rib rather than my liver. After my first time (pre-tx), I read a study that recommended fasting for at least 4 hours (the hep doc's office always says 3 hours), so for #2 and #3 I fasted 5 hours, which may have helped lower my score. The middle time (different gal), I commented that I was rooting for a score below 12 kPa; when it came out 12.2, she said there was a setting she could adjust somewhat, that "they" didn't like her adjusting it beyond a certain point, so she adjusted that setting a little, did ten more pings, and got 11.4 kPa.

I hope this confirms what Lynn said about results in mid ranges not being that accurate. Your hepatologist's office leaves a lot to be desired in the "bedside manner" department. If I were in your shoes, I'd probably be feeling like you are. Incidentally, even though my kPa scores have decreased and I had post-tx VLs at 12, 24, and 50 weeks (all UD), my hepatologist (who just turned my liver care back to my PCP) still wants me to have VLs done at 2 and 3 years post-EOT and ultrasounds every six months unless my final FibroScan (in a year) is below 9 kPa. He doesn't expect any problems; that's just his protocol. Is there any chance you can get your PCP to order the 24-week SVR test? Odds are, you're fine, but you'd feel better knowing that the rise in kPa was a fluke.

Good luck,

Gnatty

Thanks Gnatty!
I will try with my PCP.

Odd that I called my Liver Specialist to double-check whether I needed to fast or not and if so for how long.  They told me that I did not have to fast at all and I ate after leaving work immediately prior to this last fibroscan.
They were aware that I had just eaten.
« Last Edit: February 20, 2017, 10:01:14 am by SomewhereinTX »
Diagnosed November 2015
VL 1.1Mil
VL just prior to treatment beginning: 316k
F2-3
Completed 8 week Harvoni Treatment 8-18-16
Undetected after 8week EOT
Liver enzymes in normal range

Offline Angelica

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  • Posts: 29
SomewhereinTX

I am very glad to hear that. It totally explains the results of your fibroscan.  :)

Offline SomewhereinTX

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  • Posts: 30
I wonder how many of us were told to fast or didn't need to fast before a fibroscan.
Diagnosed November 2015
VL 1.1Mil
VL just prior to treatment beginning: 316k
F2-3
Completed 8 week Harvoni Treatment 8-18-16
Undetected after 8week EOT
Liver enzymes in normal range

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
  I know several people have mentioned about fasting before a Fibroscan but I haven't seen that anywhere in the literature does someone have a reference?
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

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Lynn, I don't recall whether this commentary on a study is what I saw when I had searched last spring, but it does recommend fasting for at least 4 hours:
http://onlinelibrary.wiley.com/doi/10.1111/apt.12598/full
My hepatologist says no food or water for three hours before.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

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  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Hi Gnatty

Thanks for the research I will check it out :)

yeah no one at my doctors said anything about it

Edit:

Hummm I guess if I do a future Fibroscan I will have to make sure I am fasting then they will think my liver is improved.   :)

My pre treatment Fibroscan was 27 and my one year post cure was 33 certainly disappointing. Maybe I hadn't eaten before the 1st one and I had before the second one.
« Last Edit: February 20, 2017, 10:55:58 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline SomewhereinTX

  • Member
  • Posts: 30
With my first Fibroscan I had not eaten since early morning and had it done in the late afternoon and as mentioned ate immediately before the second one.

I am seeing suggestions of several hours of fasting prior to testing and commentaries of differences in results in searches.
Diagnosed November 2015
VL 1.1Mil
VL just prior to treatment beginning: 316k
F2-3
Completed 8 week Harvoni Treatment 8-18-16
Undetected after 8week EOT
Liver enzymes in normal range

Offline elias

  • Member
  • Posts: 285
Fibrosure blood test for fibrosis requires eight hour fasting prior:

Quote
Patient Preparation    

Patient should be fasting for at least eight hours.

From: Labcorp.com

So it's not just Fibroscan that requires it. Fibrosure as well.
=============
I did not at all fast prior to that Fibrosure test last September, and I drank very high calorie drink in dr's office while waiting for the tests including the Fibrosure. So I'm now wondering if my real fibrosis level might not be a bit lower than F3  on account of this?
« Last Edit: February 23, 2017, 02:26:40 am by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: POSITIVE 12.00

Week 2:
AST: 15
ALT: 20

Week 4 VL: 0- UD
AST: 16
ALT: 20

Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
ALKALINE PHOSPHATASE: 66

Cryoglobulinemia: NEGATIVE

Week 12, after EOT: VL: 0- UD


Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline lporterrn

  • Member
  • Posts: 1,984
  • LucindaPorterRN
    • LucindaPorterRN
All these wonderful outcomes make especially good stories. Please tell your hep story at Hep Stories https://www.hepmag.com/category/hep-stories
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline cementjungle

  • Member
  • Posts: 11
Just had my 12 week post treatment testing and it came back undetected!!

12 week Harvoni treatment.  Treatment was uneventful the first 2 months, but for the 3rd month I had weird skin peeling issues on hands and feet. Perhaps dehydration or something, who knows... but rubbing Avacodo oil on hands and feet seemed to help it heal back up.
1978 (or thereabouts) contracted
2001 Discovered HepC (quit drinking immediately) Genotype 1a

Jan 2017 Viral load 22,800,000 7.36 H
Jan 2017 AST 36 ALT 65
Jan 2017 Fibrosis score 0.78 (F4)

July 2017 start tx (12 week course)

3 weeks into tx: not detected
AST 17 ALT 19

7 weeks into tx: not detected
AST 18 ALT 21

3 months post treatment: not detected

Offline gnatcatcher

  • Member
  • Posts: 1,372
cementjungle, glad to hear your great news -- both the SVR12 and your healed skin.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline cementjungle

  • Member
  • Posts: 11
Thank you Gnat!!!
1978 (or thereabouts) contracted
2001 Discovered HepC (quit drinking immediately) Genotype 1a

Jan 2017 Viral load 22,800,000 7.36 H
Jan 2017 AST 36 ALT 65
Jan 2017 Fibrosis score 0.78 (F4)

July 2017 start tx (12 week course)

3 weeks into tx: not detected
AST 17 ALT 19

7 weeks into tx: not detected
AST 18 ALT 21

3 months post treatment: not detected

 


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