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Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE!  (Read 530525 times)

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Offline Lee

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  • Posts: 31
As a follow up to a conversation I had with Charly8:  My doctor started treating her first batch of 70 patients with Harvoni at the end of 2014, so they are now taking their 24 week labs.  All 70 arrived at undetected by week 12, but today she told me only 1 of them has relapsed. So I guess it happens - there are some people with resistance.  Luckily, there are new drugs on the way, so even for those, there is still hope.

Lee
Female
Infected mid-1970's
Diagnosed 2013
Viral load prior to treatment: 6.6 million
Genotype: 1a
Started Harvoni: 4/20/15
Four week viral load: <20 too low to quantify
Eight week viral load: undetected

Offline Lynn K

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Congrats Bob

Hope to join you soon

Waiting to take my 4 week post treatment viral load right now will post results when I get them.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline dragonslayer

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As a follow up to a conversation I had with Charly8:  My doctor started treating her first batch of 70 patients with Harvoni at the end of 2014, so they are now taking their 24 week labs.  All 70 arrived at undetected by week 12, but today she told me only 1 of them has relapsed. So I guess it happens - there are some people with resistance.  Luckily, there are new drugs on the way, so even for those, there is still hope.

Lee

Are you saying that she had a patient who was UND at 12 wks post treatment then relapsed before the 24 wk post treatment test?  Or are you marking time from the beginning of treatment instead of the end??

On rereading, it sounds like youre marking time from the beginning of the treatment period.. So that when they all arrived at wk 12 Und, that would be their EOT test, and the 24 wk labs theyre now taking are really 12 wks post treatment in their SVR12 checkpoint....   

The distinction is important because while its uncommon for an UND at EOT to relapse at 12 wks post treatment, its not nearly as uncommon as it is for someone who is UND at 12 wks post treatment (SVR12) to relapse by 24 wks post treatment.. The odds of that happening are well under 1%!
« Last Edit: June 01, 2015, 08:46:21 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline terih

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  • Posts: 74
Edit: contents not appropriate for this thread, sorry!
« Last Edit: June 02, 2015, 02:28:32 pm by terih »
64 yrs. on this fine planet!
diagnosed 1993
Stage 1 cirrhosis
Genotype 1a
12 wks. Harvoni  Relapse late Feb. 2015
Currently treating with Solvaldi/Olysio
The light at the end of the tunnel, is often not a train!

Offline Lynn K

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As a follow up to a conversation I had with Charly8:  My doctor started treating her first batch of 70 patients with Harvoni at the end of 2014, so they are now taking their 24 week labs.  All 70 arrived at undetected by week 12, but today she told me only 1 of them has relapsed. So I guess it happens - there are some people with resistance.  Luckily, there are new drugs on the way, so even for those, there is still hope.

Lee

Hi Lee as I read what you are saying what I think you mean is they tested UND at EOT 12 weeks and that this was their 12 week post EOT labs.

And as Paul said yes it is possible to be not detected at EOT12 but have relapsed at 12 weeks post treatment. Sadly we have one person on this list that would apply to.

Or as we are trying to figure out did you mean they had a patient who was not detected at 12 weeks after they completed treatment who relapsed at 24 weeks after completing treatment which that would be very huge news.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Perca05

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Sorry...here is my info:

1. 4wk - 12 wk EOT VL status:  4WK VL: 20 AST 19 ALT 15
12 WK - VL - undetected   AST 20  ALT 15
2. Treatment duration:  12 Weeks
3. tx naive or experienced:   Experienced
4. Genotype (1a or 1b):  1a
5. F1-F4 fibrosis status (date):  not known
6. Initial VL (date):  Contracted in the 80's.  Starting VL was 4.5 million

Hope this helps!  And I hope I do not relapse!

Caroline


Offline Lynn K

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Just a reminder of the original intent of the thread although of course we want to congratulate our friends who make SVR and celebrate being not detected on treatment

After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE!

Now that a lot of people are coming off treatment, we need a tally of peoples status.

NOTE: Please post only if you have results from post EOT tests SVR 4wk thru SVR 12wk after EOT. 

Please list only SVR4 or SVR 12 status.  No results on tx or at EOT because most are undetected then anyways.

Please list the following: (copy and paste into your post as I have done below to keep this thread clean)
1. 4wk - 12 wk after EOT VL status
2. Treatment duration
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)
« Last Edit: June 02, 2015, 02:09:35 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bob V

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Hi guys, I've been busy the last couple of weeks and have not logged to the forum, sorry. I'll check back later to see how everyone else is doing.

Anyway, just got my 12wk post labs back, UND!

1. 4wk - 12 wk after EOT VL status : 12wk Post TX UND
2. Treatment duration: 12wks
3. tx naive or experienced: Experienced
4. Genotype (1a or 1b) 1a
5. F1-F4 fibrosis status (date): not done
6. Initial VL (date): Pre Tx 3.7m, dx early 90's
« Last Edit: June 02, 2015, 10:51:38 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Mugwump

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  • My number of posts means nothing, piscor ergo sum!
Right on BOB!
I am hoping to hear some 24 week tx individuals chime in. But I guess there are not that many of us around yet.

My recent UND just today at EOT is a wonderful thing to hear though. I will not be going for a 4 week VL, Just liver panels until 12 week post treatment and that is the biggy for me so, as more people reach 12 week UND makes my day, week, year... OH what the heck this is FANFREAKIN' TASTIC!

ERIC
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Katie

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AWESOME!  I'm putting on my dancing shoes right now to do the HAPPY DANCE FOR BOTH OF YOU!

Do something special for yourselves and be filled with JOY!  I know there is still some more waiting and tests to be done, but it is a huge step towards permanently eliminating this alien monster and having a healthy life.

I am SO happy for both of you!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Bob V

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Eric and Katie
Thanks
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Bob V

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  • Posts: 231
LynnK
Is #6 pre treatment VL or back when first dx?
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
I didn't set up the original list but I am assuming most recent before treatment would be most relevant viral load
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bob V

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  • Posts: 231
Bituman
Congrats Bob.
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Bob V

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Thanks Lynn
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Lynn K

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And oh yes where are my manners

CONGRATS BOB FANTASTIC NEWS!!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Bob V

  • Member
  • Posts: 231
Lynn
Lol, thanks.
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline BattleTheBeast

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  • Posts: 817
  • Female, 57 - SVR12 as of 7/23/15!!
Hi All,

Well I just got the great news that I am SVR4; all other numbers look great and my doc says I am at 99.8% which means he has declared me cured but I will be getting the SVR12 test the end of July.

Now I am dealing with the awful RA like symptoms that hit me about 8 weeks into treatment. I am seeing a Rheumotologist but most mornings it is taking me 2-3 hours to be able to use my hands normally and having lots of other pain in my lower back and hips. It's all good, I will beat this crap too!

Hope you are all well,

Mel
~Mel~
Hep C, Type 1, 10/11  viral load 8,238,340, AST-60, ALT-57 Bili .6  Stage 4 cirrhosis,
Week 4 VL <15 AST 20 - ALT 27 Bili .9
Week 9 - switched to Harvoni VL UD!! AST 20 ALT 19

EOT date is 4/30/2015,
SVR 12 is 7/23/15 ACHIEVED!!! 
and SVR 24 ACHIEVED!!

Offline Bob V

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BattleTheBeast
YAY! Mel :)

Sorry about the RA :(
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Lynn K

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Hi Mel

Alright SVR4 fantastic news!

I think I have read SVR4 is 98.5% and SVR12 is 99.8% but it's all good either way!

I just did my 4 week post test I have my liver functions back and they are still normal. When I relapsed last year on S/O my liver tests ALT was again above normal. So far so good. Should have my viral load back soon.

Sorry to hear about your continuing trouble with RA yes you will beat this crap too!

Battle on warrior Mel!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline TerryLF

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  • Posts: 9
It's been a while since I was here last. I just finished 12 weeks of Harvoni and my blood work came back detected. I was given twelve weeks treatment. I have cirrhosis but was treatment naive hence the twelve weeks.

My doctor says that's it, nothing else can be done. I'm pretty bummed about all this as I was very happy to finally get treatment and was undetected at 4 weeks. My viral load after 12 weeks is low at 120, but it is still there. Having a difficult time processing all of this.

Offline dragonslayer

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It's been a while since I was here last. I just finished 12 weeks of Harvoni and my blood work came back detected. I was given twelve weeks treatment. I have cirrhosis but was treatment naive hence the twelve weeks.

My doctor says that's it, nothing else can be done. I'm pretty bummed about all this as I was very happy to finally get treatment and was undetected at 4 weeks. My viral load after 12 weeks is low at 120, but it is still there. Having a difficult time processing all of this.

While not as low as some others, its not high either, and there are several instances of low detected viral loads at EOT resolving to SVR at 12 wks post treatment.  Find the threads here on this for support.. Dont count yourself out quite yet. Besides, even if it does not clear by 12 wks post, the newer drugs coming on line soon look to be even more effective, so its definitely not over for you.
« Last Edit: June 03, 2015, 08:54:08 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Bob V

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  • Posts: 231
TerryLF
Sorry about the lab result and I would have a hard time processing that too. But I'm with Paul don't count yourself out yet and yes there's some newer, better drugs coming soon.
Again Sorry, Bob
« Last Edit: June 03, 2015, 05:25:12 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Lynn K

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Hi Terry sorry about you news really a bummer hugs to you.

Was that your EOT test after just finishing treatment?
Or was that a 12 week after treatment had ended?

Like Paul and Bob said you may not be out of the fight just yet. And there are newer treatments coming soon as well so don't give up!

Hugs to you
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline ma snart

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  • Posts: 65
Helen, 4 weeks post Harvoni 24 week program  UNDETECTED
Ma
Helen 54 yr old female
Geno 1B since 84 from transfusion
started Harvoni on 11-22-14 with 8.5 million viral
After 8 days 933 viral and normal AST and ALT
Week 10 viral load  UNDETECTED
Week 17    detected 19
Week 18    detected 21
Week 20    UNDETECTED   Doctor did prescribe Ribavirin, but have not taken it yet as we are thinking that weeks 17,18 had to have been mishandled.
All other test have shown normal levels.
Week 21 results  on Tuesday 4-21
Week 4 post Harvoni 24 week plan UNDETECTED!!

Offline Bob V

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  • Posts: 231
Yay Ma, congrats!

Sorry Helen :)
« Last Edit: June 03, 2015, 10:10:40 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Yay for Helen !!!

Congrats to you both!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline TerryLF

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  • Posts: 9
Thanks to the people who responded to my  comment. For Lynn, it was my end of treatment test. I was hoping maybe there could possibly be some residual RNA or something like that that my body just hadn't cleared yet, I don't know. My doctor just told me to come back in six months to monitor my liver processes. My real problem is that my coverage is through the state of Illinois Medicaid, I am able to work, but am limited physically (not from HepC, but other physical problems) so I can't work a lot. The state of Illinois only pays for treatment once and you're done. I have filed for disability, and if that is approved, I may have a shot with Medicare. Who knows.

Offline Katie

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  • Posts: 784
Terry,  please check this  site out.  There have been 3 of us test Detected at EOT and have gone on to clear.  I suggest you have another VL test at 12 weeks to see if this is what is happening.

http://forums.hepmag.com/index.php?topic=2383.0

These articles would be good to share with your doctor.

http://hepatitiscnewdrugs.blogspot.com/2015/03/hcv-rna-does-not-always-mean-treatment.html
http://www.hivandhepatitis.com/hcv-basic-science/5160-croi-2015-hcv-viral-load-and-speed-of-decline-do-not-predict-cure-with-interferon-free-therapy

Good luck to you.  It is so frightening when you get this news and I know what you are going through, but it could be that you will clear.  Keep us informed as we all learn from each other and can help others.  This drug is so new, many doctors do not know all of the latest findings.

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline TerryLF

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  • Posts: 9
Thanks Katie. I read the articles and I will bring this to the doctor's attention. This gives me something to hope for. I was surprised that I tested positive at EOT since I was undetected at four weeks.

Offline Katie

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  • Posts: 784
Evidently  being undetected during treatment is common however even at EOT it isn't anything more than stating you were a strong responder AND it depends on the sensitivity of the test as well.  The test at post 12 is what counts and that's why it is the important one and actually could be the only one they test in the future.

When I first read these article which came out after my disappointing results, I became very excited...cautious but excited and it worked out for me!  I was VL = 59 at 4 weeks and detected < 15 IU/mL at EOT so at 8 weeks post treatment my doctor tested again and I was Undetected  VL = 0.  I still will remain cautious until I have my SVR 24 and then will feel confident that I am cleared!

Hang in there.  You are not alone!

Katie

ps:  This thread is primarily for those who have tested post treatment at week 4 & 12 so it probably would be good to use the other forum for future comments.   :D

http://forums.hepmag.com/index.php?topic=2383.0
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline cate

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  • Posts: 10
Greetings!

Cate here. I've only posted a couple times. Thank you for this compilation. It's been interesting to watch the results come in.

Here are my 4 week EOT results that I received this evening.
1. 4wk: UND
2. Treatment duration: 20 weeks. I was originally scheduled for 12 but I was a slow responder and still detected slightly at week 8 but UND at week 12. I was able to get approval for 2 more months of Harvoni from insurance, thankfully.
3. Tx Naive
4. Genotype: 1a
5. F1-F4 fibrosis status: Ultrasound and Fibroscan before treatment start date (12/16/14) indicated early cirrhosis. 
6. Initial VL: 2.5 mil at pre-treatment physical about three weeks before I started treatment.

My doctor would like me tested again in 4 weeks so I will post again.

Sending kindness and hope to all of you.

Cate
Harvoni Start Date: December, 2014 for 12 weeks

Week 8: Revised treatment plan to 20 weeks due to slow response and slight VL

Last pill: Early May (EOT)

June 4 Update: Week 4; Post Treatment - UND!

Geno 1a
Early cirrhosis
Treatment Naive

Offline BattleTheBeast

  • Member
  • Posts: 817
  • Female, 57 - SVR12 as of 7/23/15!!
Helen, 4 weeks post Harvoni 24 week program  UNDETECTED
Ma


So Happy to hear this news!! Congratulations!!

Mel
~Mel~
Hep C, Type 1, 10/11  viral load 8,238,340, AST-60, ALT-57 Bili .6  Stage 4 cirrhosis,
Week 4 VL <15 AST 20 - ALT 27 Bili .9
Week 9 - switched to Harvoni VL UD!! AST 20 ALT 19

EOT date is 4/30/2015,
SVR 12 is 7/23/15 ACHIEVED!!! 
and SVR 24 ACHIEVED!!

Offline Bob V

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  • Posts: 231
Greetings!

Cate here. I've only posted a couple times. Thank you for this compilation. It's been interesting to watch the results come in.

Here are my 4 week EOT results that I received this evening.
1. 4wk: UND
2. Treatment duration: 20 weeks. I was originally scheduled for 12 but I was a slow responder and still detected slightly at week 8 but UND at week 12. I was able to get approval for 2 more months of Harvoni from insurance, thankfully.
3. Tx Naive
4. Genotype: 1a
5. F1-F4 fibrosis status: Ultrasound and Fibroscan before treatment start date (12/16/14) indicated early cirrhosis. 
6. Initial VL: 2.5 mil at pre-treatment physical about three weeks before I started treatment.

My doctor would like me tested again in 4 weeks so I will post again.

Sending kindness and hope to all of you.

Cate

-----------------
Cate, first congrats on your UND results.

 Your 20wk treatment got my attention, my brother was still positive at week 9 or 10 and his doc's, he has several, tried to get approve for addition weeks but he was denied. Several months ago I had a thread on this subject. My thing was just add 28 more doses after positive lab result but for most people it's not going to be approved. This hit home with several posters and at the time it looked like a no-brainer. I still think this "might" be a good way to go but looking at some of new data, people are positive at EOT but are negative several weeks later. So from a $$$$ point of view I can see why people are denied. My bro was UND at EOT but I'm still waiting to hear on his 12wk results.

Again,congrats, Bob

Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline cate

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Hi Bob,

I believe it was my doctor's letter to the insurance company that sealed the additional 2 months of Harvoni. There isn't much research about "slow responders" and the insurance companies follow protocol from what the FDA and Medicare recommend. My doctor informed the insurance company that I have early-stage cirrhosis, I am 62, and that re-treating and God forbid a liver transplant would be much costlier than an extension of the current meds. She actually broke down the costs in her letter. She is just amazing!

But I'm not out of the woods yet. According to the Harvoni researchers, I've a 5% chance of relapse between now and my 12-week EOT mark.

Kind regards,
cate
Harvoni Start Date: December, 2014 for 12 weeks

Week 8: Revised treatment plan to 20 weeks due to slow response and slight VL

Last pill: Early May (EOT)

June 4 Update: Week 4; Post Treatment - UND!

Geno 1a
Early cirrhosis
Treatment Naive

Offline Bob V

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  • Posts: 231
But I'm not out of the woods yet. According to the Harvoni researchers, I've a 5% chance of relapse between now and my 12-week EOT mark.
--------------
That stat seems a little high but what do I know..lol. Sending good vibes your way.

Bob

Ok just remembered 4wk result so maybe 5% but let's not go there :)
« Last Edit: June 04, 2015, 12:39:25 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline cate

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Hi Bob/all,

I checked back with the HCV researcher to make sure I had quoted accurate information regarding the 5% relapse rate EOT between weeks 4 and 12. (The doctor I'm quoting has been an HCV researcher at Duke for quite some time.)

Here's the text I received from him, verbatim. My post about 5% was not quite right - he's stating that there's 5% relapse between last pill and week 4 EOT.

"Only about 5% relapse, of those 5%, about 98% relapse by week 4, thus only 2-3% or chance of 1 in 30 to 1 in 50 that the virus would come back."
Harvoni Start Date: December, 2014 for 12 weeks

Week 8: Revised treatment plan to 20 weeks due to slow response and slight VL

Last pill: Early May (EOT)

June 4 Update: Week 4; Post Treatment - UND!

Geno 1a
Early cirrhosis
Treatment Naive

Offline dragonslayer

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  • Posts: 873
Bob/Cate,

What were these EOT viral loads youre speaking about?  Were they low value detected or high?  You know that many low detecteds at EOT go  on to resolve at 12 wks post treatment... On treatment testing for most with Harvoni isnt real instructive or predictive.
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline mario555

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  • Posts: 226
If I can put my grain of salt... What is being said is that 95% of people will be cured with Harvoni.  For the 5% who don't, most of them will relapse by week 4 after the end of treatment (98% of the 5 %). The other 2% will relapse between week 4 and 12 (except for rare cases like Lynn K who relapsed way later).  So, If you clear the 4 week mark, chances are high you will be cured for good.
60 years old. Likely infected 1975. Geno 1a
F4  8 millions VL,  AST 140  ALT 140
Generally in good health except problems are creeping up rapidly!
2 failed attempts Inf 2000 and Inf-riba 2010
Harvoni 24 weeks
Start 11/13/2014   EOT 4/27/2015
VL2 - UND
VL4 - UND (may 25)
VL12 - UND
VK24 -  UND
Hopefully cured forever!

Offline Katie

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  • Posts: 784
Just to be clear, Lynn wasn't on Harvoni when she relapsed.  She just finished her Harvoni treatment.
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline cate

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  • Posts: 10
Mario, yes, your summary regarding the end of treatment statistics noted below are accurate:

"What is being said is that 95% of people will be cured with Harvoni.  For the 5% who don't, most of them will relapse by week 4 after the end of treatment (98% of the 5 %). The other 2% will relapse between week 4 and 12 So, If you clear the 4 week mark, chances are high you will be cured for good."

cate
Harvoni Start Date: December, 2014 for 12 weeks

Week 8: Revised treatment plan to 20 weeks due to slow response and slight VL

Last pill: Early May (EOT)

June 4 Update: Week 4; Post Treatment - UND!

Geno 1a
Early cirrhosis
Treatment Naive

Offline motor

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  • Posts: 58
I feel like a Harvoni success stat and should be added to the numbers.  The catch is my dr waived off my SVR4 test as unnessary.
   All requested info is in my signature.  And further awesomeness of signature is that updated info changes in my signature.  I won't have to clutter the thread with another post.
Age 66male GT 1a/CT  Dx 5/19/14
Likely infected early 70's
VL 3.7mil FibroScan F2 FSure F2
ALT 84(12-78) AST 56(3-36) High
Tx naive
8wks Harvoni start 3/3/15 VA
4wks ALT 25(12-78) AST 22(3-36) Normal 
        VL  <15  NOT DETECTED
8wks ALT 24 AST 19 
EOT  VL   <15  NOT DETECTED
SVR12 VL <15  NOT DETECTED

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
And I was not tested at 4 weeks post Sovaldi Olysio I was only tested at 12 weeks post EOT.

I no idea when I relapsed in relation to my EOT.

We were only going to test at 12 weeks again this time but I asked if we could do a 4 week post EOT Harvoni. I have my liver function back so far so good still in notmal range but the did increase a bit.

6/4/15
ALT (GPT)   <33 U/L   26
AST(GOT)   0 - 40 U/L   28

from EOT 5/4/15
ALT (GPT)   <33 U/L   21
AST(GOT)   0 - 40 U/L   20

this was my relapse S/O test so prior to Harvoni 9/3/14
ALT (GPT)   <33 U/L   56
AST(GOT)   0 - 50 U/L   45 (different ref range)

Waiting for week 4 post viral load results.......
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline charly8

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  • Posts: 113
Ok its been a while and we now have a lot more responses!

Updated Stats for the 16 following member responses (ALL UNDETECTED):
007Guy (SVR4, 12wk)
Mike Conwell (SVR4, 12wk)
Sam1224 (SVR3.5, 16wk)
Valance (SVR12, 8wk)
MEG (SVR4, 12wk)
Workingonit (SVR12, 12wk)
Kate101 (SVR6, 12wk)
HCVDX30 (SVR12, 12wk)
Roger (SVR12, 12wk)
Charly8 (SVR4, 12wk)
Bituman (SVR4, 12wk)
Marnie (SVR4, 12WK)
BOB V (SV412, 12WK)
BattleTheBeast (SVR, 12WK)
Ma Snart (SVR4, 24WK)
Cate (SVR4, 20wk)

Mario555, I did not include your SVR2 in the tally because it is still early and there is not a lot of data regarding tests that early. 

So far nobody has reported a SVR4 and then subsequently relapsed.

Current Status
We have 40 people that hit at least the 4 week post tx mark.  7 of 40 have relapsed.  (17.5%)

Breakdown by treatments
8 weeks of tx - 4 of 8 have relapsed (50%)
12-24 weeks of tx- 3 of 32 have relapsed (9.38%)

Note:  We currently have a 17.5% relapse rate.  This is with very limited data and certainly not scientific.   Note: This poll probably skews towards relapse as people that get SVR results are more likely to have moved on with their lives and not reported back to the forum.

The latest results are all GOOD NEWS with no additional relapses.  Now that more people have reported results, the 12 week treatment people are starting to align more with the Gilead's results of <5% relapse rates. 

I am surprised that there have not been more responses for the 8 week treatment people.  Remember if you are doing 8 weeks this tally is not scientific and does not mean that you have a high relapse rate.
« Last Edit: June 05, 2015, 09:25:41 am by charly8 »
1a, VL  1.05 Mil, ALT 47
Fibrosure F3 December 2014
Fibroscan F0-F1 March 2015
1995 INT & RYB -non-responder
2007 PEGIN & RYB 72 weeks tx - partial responder relapsed
1/23/15 Started Harvoni 12 weeks, EOT 4/17
2 week blood work -  <15 Und. (ALT 25)
4 week blood work - <15 Und. (ALT 29)
2/20/15 added RYB (4 weeks into 12 of tx)
8 week blood work - <15 Und. (ALT 23)
(EOT) 12 week blood work - <15 Und.
4wk POST tx VL - Und. (ALT16, AST 17)

Offline Katie

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  • Posts: 784
Thanks Katie. I read the articles and I will bring this to the doctor's attention. This gives me something to hope for. I was surprised that I tested positive at EOT since I was undetected at four weeks.

Terry, another person has posted where the VL doubled at EOT and they tested at 4 weeks post tx and got an UD.  You definitely need to be tested again.  Anyone else who relapsed might want to go in for more bloodwork.  I have a feeling some of our 8 week relapsed folks may benefit from this.

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline CHepCFree

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  • Posts: 66
Please list the following: (copy and paste into your post as I have done below to keep this thread clean)
1. 4wk - 12 wk EOT VL status - Undetected
2. Treatment duration - 12 weeks
3. tx naive or experienced - naive
4. Genotype (1a or 1b) - 1a
5. F1-F4 fibrosis status (date) - F0-F1
6. Initial VL (date)  7,200,000

(with complications of heart and lungs post treatment)

Offline Junkyard

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  • Posts: 24
Just got blood results from 4 w EOT. Undetected. My doc was out and they did not send all the results but it is great news so far.
I have noticed some small things that are better but it seems as though I am way out of shape because I do some hard work and I am sore and getting more sore.
This news makes me feel much better. Now back to work.
Good luck to all. There is hope


1a viral load at tx 960,000
Biopsy about 5 years ago diagnosed
Probably have had since early 80's
Null responder inter and riba
Relapsed telaprivir riba inter
Alt Ast in the 100 range
Undetected at 4weeks tx
Alt Ast in the normal range
Treatment 12 weeks
Harvoni and ribaviri

Offline Lynn K

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  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Just got my 4 week post treatment viral load results


1. 4wk after EOT VL status: NOT DETECTED
2. Treatment duration: 5th treatment 11/14 to 5/15, Harvoni 24 weeks, Ribavirin 15 weeks
3. tx naive or experienced: Experienced
4. Genotype: 1a
5. F1-F4 fibrosis status: F4 Cirrhosis 01/08 Biopsy
6. Initial VL: September 2014 (after relapsing 12 weeks post Sovaldi Olysio)

HCV RNA RT-PCR, QT   2422260

HCV LOG 10   6.384


Wow!

Oh happy day Junkyard!
« Last Edit: June 05, 2015, 04:13:59 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Katie

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  • Posts: 784
Lynn!!!!  You Just made my Day!  OMG girlfriend a very special HAPPY DANCE for you!!

Congratulations and forward to an SVR12 and SVR24!

Love it!

Katie

1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline terih

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  • Posts: 74
Lynn K. Wonderful news! I bet you are incredibly happy and relieved right now! Congrats on your successful battle!
64 yrs. on this fine planet!
diagnosed 1993
Stage 1 cirrhosis
Genotype 1a
12 wks. Harvoni  Relapse late Feb. 2015
Currently treating with Solvaldi/Olysio
The light at the end of the tunnel, is often not a train!

Offline ma snart

  • Member
  • Posts: 65
Congrats Lynn.....
welcome to the club.
Ma
Helen 54 yr old female
Geno 1B since 84 from transfusion
started Harvoni on 11-22-14 with 8.5 million viral
After 8 days 933 viral and normal AST and ALT
Week 10 viral load  UNDETECTED
Week 17    detected 19
Week 18    detected 21
Week 20    UNDETECTED   Doctor did prescribe Ribavirin, but have not taken it yet as we are thinking that weeks 17,18 had to have been mishandled.
All other test have shown normal levels.
Week 21 results  on Tuesday 4-21
Week 4 post Harvoni 24 week plan UNDETECTED!!

Offline charly8

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  • Posts: 113
Great Job Lynn, very happy for you!  You too Junkyard
1a, VL  1.05 Mil, ALT 47
Fibrosure F3 December 2014
Fibroscan F0-F1 March 2015
1995 INT & RYB -non-responder
2007 PEGIN & RYB 72 weeks tx - partial responder relapsed
1/23/15 Started Harvoni 12 weeks, EOT 4/17
2 week blood work -  <15 Und. (ALT 25)
4 week blood work - <15 Und. (ALT 29)
2/20/15 added RYB (4 weeks into 12 of tx)
8 week blood work - <15 Und. (ALT 23)
(EOT) 12 week blood work - <15 Und.
4wk POST tx VL - Und. (ALT16, AST 17)

Offline Karen3717

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  • Posts: 28
@ Lynn and all the other folks who have recently gotten great news.....Congratulations to all!  I finished 12 weeks of tx with Harvoni yesterday, had 12 week labs done yesterday, & got my results back today............UNDETECTED!!!!!  This has been such a roller coaster of emotions  because I have been detected < 15 since the beginning of treatment.  I just know in my heart that Harvoni was the cure I had been waiting on for so long.  I have had Hep C for 30+ years and now have hope that it is finally GONE!  I plan to re-test in 4 weeks.

Best wishes to everyone still on treatment....hang in there.  BTW, last time I saw my doctor @ UTSW-Dallas, I was told that NONE of his patients had relapsed.  I know it's still early and many are just finishing up treatment, but that is SO encouraging to hear.   Cheers!!  KEEPING THE FAITH!!!
Transfusion 1982; Multiple accidental needlesticks; healthcare worker
(+) HCV antibody 1991
Genotype 1a
2001-Pegintron/Ribavirin 48 wks. Relapse 2mo post tx
2015-VL 316,000
Fibrosure-F2
Started Harvoni 3/13/15
2 weeks:  HCV PCR <15-DETECTED
4 weeks: HCV PCR <15-DETECTED
8 weeks: HCV PCR <15-DETECTED
12 weeks:  HCV PCR: NOT DETECTED!
4 Weeks EOT: HCV PCR:  NOT DETECTED!
12 Week post TX:  HCV PCR NOT DETECTED!

Offline Katie

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  • Posts: 784
A big Congratulations to you Karen and Junkyard and anyone else I have missed!  It is so wonderful to see the positive results come in and for those who have relapsed, I encourage you to get another blood test as many of those detected at end of treatment and even one at 7 weeks ended up clearing the virus.  Please see this thread:
http://forums.hepmag.com/index.php?topic=2383.0

and read these reports for more information:

http://hepatitiscnewdrugs.blogspot.com/2015/03/hcv-rna-does-not-always-mean-treatment.html
http://www.hivandhepatitis.com/hcv-basic-science/5160-croi-2015-hcv-viral-load-and-speed-of-decline-do-not-predict-cure-with-interferon-free-therapy
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Bituman

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  • Posts: 157
Just got my 4 week post treatment viral load results

Wow!

Oh happy day Junkyard!

Way to go Lynn.  So happy for you.  After all your treatment experience, you really deserve this!

All the best,

Bob

Edit:  i just realized we aren't supposed to post congrats in this thread, my bad.  But after all, we're talking about Lynn here. 
« Last Edit: June 06, 2015, 08:15:10 am by Bituman »
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline kate0b1

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  • Posts: 293
OMG i can't even keep up with all the good news here, @charly8 thank you so much for keeping up with this, it seems to be a lot of work  :), @lynn, mel, helen and everyone else that i can't keep up with CONGRATS !!!
I just had my 12 week post done so i should be able to update next week sometime

go us  8)

Offline Reek34

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  • Posts: 9
Katie invited me over to this thread, love seeing and giving positive news.

I got the 8 week treatment, was given a test at the end, 7.5 weeks and my VL had doubled and my doc said it was a failure, and started trying to get me Viekra Pak.

Here's my info:

1. infected around 2000
2. Treatment Naive
3. VL prior to tx: 500k
4. EOT blood test at 7.5 weeks: Detected: VL Doubled to 1.1 Mill, but my AST and ALT went down to the normal range, AST went from 73 down to normal range: 22 and ALT went from 121 down to normal range: 29

5. 12 week blood test (4 weeks post tx) went to UND !!!

I am really excited to get this news and almost wish my doc would have waited to do blood until 4 weeks post.. I was stressing each test and let it get to me.

My doc told me that I failed the tx when we saw my EOT blood work and I was devastated. I didn't start feeling better until I started forgetting about the test and focused on staying healthy and living.

Hoping for more good news at the 24 week mark!

Male 37
Hep C 2001
GT 1A
VL 500k (pre tx)
Ultrasound 2014, normal
Started Harvoni 02/15/2015 (8wks)
Finished Harvoni 04/15/2015
7.5wk EOT lab VL double to 1.7 mill
4 wk post lab UND!

Offline Ollie

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  • Posts: 11
1. 4wk - 12 wk EOT VL status - undetected
2. Treatment duration- 12 weeks
3. tx naive or experienced-naive
4. Genotype (1a or 1b)- 1a
5. F1-F4 fibrosis status (date) F1 -1/08
6. Initial VL (date)12/07 400,000. Highest was 1 mil but down to 600,000 when starting Harboni in Dec. 2014

Yay!! My Dr. Said no need to be tested 24 weeks post treatment said I am cured!!

Offline Katie

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  • Posts: 784
A big congratulations Ollie!  Great news, but if it were me I would want a follow up test.  I wouldn't want any surprises down the road.

Enjoy the freedom Harvoni has given you and take good care of yourself! 

The best to you,

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Bob V

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  • Posts: 231
Lynn, Junkyard, Ollie

GREAT NEWS! CONGRATS!!!!!!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Katie

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  • Posts: 784
A big congratulations Ollie!  Great news, but if it were me I would want a follow up test.  I wouldn't want any surprises down the road.

Enjoy the freedom Harvoni has given you and take good care of yourself! 

The best to you,

Katie

Ollie...I misunderstood and now see you had a 12 week post test.  I looked at it wrong.  :)
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Ollie

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  • Posts: 11
Yes. Finished treatment 2/26/15. Tested end of May: Undetected. All enzymes normal. I asked re:a 24 week post treatment test and Dr. said no need. New standard is  to test 12 week post treatment and if undetected IM CURED!! I asked about next visit and they said no need unless I had some other GI issues. Yahoo!! I can't believe this ordeal is over!! Good luck to all of you still fighting. I wish you well!!
 

Offline MEG

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  • Posts: 304
Lynn!

Woooooo-hoooooooooooooooo!!!!!!

I can't tell you how happy I am for you! Yes! Yes! Yes~!

And I know I'm not alone. You've been a model of grace under huge pressure and a kind shoulder and resource for all of us when you were having your own anxieties about the uncertainty of all this......Bless you. I'm going to be walking on air today I'm so happy.

Shoutout to all others who posted...I'll get back to you later, "personally." ;-) I needed to express my joy for my girl Lynn!
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline Lynn K

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  • Member
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  • Get tested, get treated, get cured, fight Hep c!
Why Thanks Meg aww shucks I am blushing just relieved to be here and hoping it holds.

Congrats to all the SVR folks

Have to climb a hill lift up our kilts and shout freedom!!!!!!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline MEG

  • Member
  • Posts: 304
;-) Lynn. Got my hiking shoes on...;-)
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline Lynn K

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  • Member
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  • Get tested, get treated, get cured, fight Hep c!
Okay who is bringing the blue face paint?
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline texasone

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  • Posts: 1
Finished 12wk treatment end of April of Harvoni, Genome 1a, 30 day test afterwards was positive and did another one week later and was positive. Not thrilled.

Offline Bob V

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  • Posts: 231
Texasone
Sorry that's got to be a bummer for you but I wouldn't loose hope just yet. I would get another lab at 12wk post tx.
 At the moment this won't make you feel any better but there's some new drugs coming soon if nessary.
Good luck and again sorry :(
« Last Edit: June 08, 2015, 03:44:15 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Reek34

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  • Posts: 9
Sorry to hear texasone,

I know that result can make you feel low. Try not to focus on it and stay positive. I know that's easier said than done.
Was the result in the millions or a low detection? Is this your first try at treatment? 
Male 37
Hep C 2001
GT 1A
VL 500k (pre tx)
Ultrasound 2014, normal
Started Harvoni 02/15/2015 (8wks)
Finished Harvoni 04/15/2015
7.5wk EOT lab VL double to 1.7 mill
4 wk post lab UND!

Offline dragonslayer

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  • Posts: 873
Yea, Tex, give us more information to help you with..  what were your viral loads on your 4wk and 5wk post treatment tests?    Its very important to see what direction your viral loads are going, and how large they are..  If theyre small, look at my signature detail for some encouragement.
« Last Edit: June 08, 2015, 02:41:54 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Junkyard

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  • Posts: 24
Is it unusual for the AST and ALT to somewhat spike after tx?
I just got all the info on my 4wk EOT labs. My Ast has risen to 46 and ALT to 29. The last labs I did was before EOT about 1 week. My Ast was 38 and ALT was 25.
I hope this is not a precursor to something bad.
My vl was und and everything else seems to be coming back after 12 wks of riba and harvoni.
I plan to ask my dr about this as well.  This may be a long 7 weeks to wait

Offline pmm

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  • Posts: 10
YAY!!! I got my 12 week SVR-UNDETECTED! My doctor did a 4 week test during treatment (undetected) and one at end of 8 week treatment (also undetected). And the side/after effects have gone and I feel back to normal.

1. 12 wk EOT VL status - Undetected
2. Treatment duration - 8 weeks
3. tx naive or experienced - naive
4. Genotype (1a or 1b) - 1b
5. F1-F4 fibrosis status (12/14) - F0
6. Initial VL (12/14)  4,700,000
Pattie
Genotype 1b; VL 4103970; AST 37, ALT 28;
FibroSURE: .18  F0
dx 1995; tx naive
Started Harvoni 12/27/14

Offline Bob V

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  • Posts: 231
Pattie
Congrats!
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline pmm

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  • Posts: 10
Thanks Bob!
Pattie
Genotype 1b; VL 4103970; AST 37, ALT 28;
FibroSURE: .18  F0
dx 1995; tx naive
Started Harvoni 12/27/14

Offline Katie

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  • Posts: 784
Here's your HAPPY DANCE PATTIE!  WOOOO HOOOO  wAY TO GO GIRL!

Do something nice for yourself and relax and enjoy your healthy life.  Great News!

Katie
« Last Edit: June 09, 2015, 10:33:51 pm by Katie »
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Katie

  • Member
  • Posts: 784
Is it unusual for the AST and ALT to somewhat spike after tx?
I just got all the info on my 4wk EOT labs. My Ast has risen to 46 and ALT to 29. The last labs I did was before EOT about 1 week. My Ast was 38 and ALT was 25.
I hope this is not a precursor to something bad.
My vl was und and everything else seems to be coming back after 12 wks of riba and harvoni.
I plan to ask my dr about this as well.  This may be a long 7 weeks to wait

The viral load is the biggie and the 12 week post is the important one.  May just be something else or just due to the Riba.  I am not that informed about that but others here are.  Talk to your doctor but don't let your imagination run with this.  You are doing good so far!  Congratulations on being Undetected.  That is huge!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline pmm

  • Member
  • Posts: 10
Thank you Katie! I am so happy now!
Pattie
Genotype 1b; VL 4103970; AST 37, ALT 28;
FibroSURE: .18  F0
dx 1995; tx naive
Started Harvoni 12/27/14

Offline Katie

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  • Posts: 784
Opps...sorry I spelled you name wrong Pattie.  I'll fix it.
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Junkyard

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  • Posts: 24
Thanks Katie
I really do know that, it is just a roller coaster that is sometimes tough. I have sent a message to my doc. I am sure he will say the same thing, it is just always in the back of the mind.
Thanks again
Junkyard

Offline dragonslayer

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  • Posts: 873
Is it unusual for the AST and ALT to somewhat spike after tx?
I just got all the info on my 4wk EOT labs. My Ast has risen to 46 and ALT to 29. The last labs I did was before EOT about 1 week. My Ast was 38 and ALT was 25.
I hope this is not a precursor to something bad.
My vl was und and everything else seems to be coming back after 12 wks of riba and harvoni.
I plan to ask my dr about this as well.  This may be a long 7 weeks to wait

These liver function values fluctuate..  The difference in the numbers you're quoting is tiny; I'd view it as noise in the system.
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Mugwump

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  • Posts: 775
  • My number of posts means nothing, piscor ergo sum!
These liver function values fluctuate..  The difference in the numbers you're quoting is tiny; I'd view it as noise in the system.
I have to agree. If the small increase in AST especially was due to liver cells being killed by HCV then the VL would certainly not be UND. Those of us with F4 and a high body mass can expect higher alt and ast during and post treatment. Not that I would do it but if someone had more than a few ounces of booze a day or two before a LP test, the result could very well scare the doctor and the patient. It would not be surprising to see AST up in the 60s or 70s if someone did this.

Normal AST for many is in the 30-40s and a constant reading of over 60 is a key indicator of advancing cirrhosis. I am sure if I lose some pork this summer my AST will come down though because fatty liver disease can be a double curse especially if you have other liver issues to deal with.

But to hell with it for now I am going out to get myself a nice MooseTrax ice cream sundae!

Cheers
Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline HHburme

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  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
started Harvoni 12/13/14....4 wk ud 8 wk ud 12 wk ud , 12 eot 3 million vl. Harvoni did not work and being ud on all previous tests. Totally devastated. sorry

John
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline Bob V

  • Member
  • Posts: 231
John, wow that sucks, sorry :( you need time to process this then start looking into the new drugs coming out...bottom line don't give up.

Again sorry.
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Katie

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started Harvoni 12/13/14....4 wk ud 8 wk ud 12 wk ud , 12 eot 3 million vl. Harvoni did not work and being ud on all previous tests. Totally devastated. sorry

John

What crippling news.  I am so sorry and it just makes no sense.  So sorry.  I have a test at 16 weeks which is on the 25th.  I was detected at EOT and at 8 weeks post undetected, so now I am worried not just for me but for all of us.

Just know they are still coming up with other treatments and it won't be long until they find something that works for everybody.  Not much comfort right now but hope is still there so don't give up.

Sending you a big ((((HUG)))) John!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline dragonslayer

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  • Posts: 873
Yea; really horrible news.  Each time another one of these pops up, it shakes everybody to the core... Its a real gut shot to those of us who think weve reached SVR;  creates a deep sense of vulnerability in everyone... And for John, who tested UND while on treatment at 4 wks, 8wks, and EOT, what a cruel turn of events.   What a cruel irony of being Undetected throughout treatment only to relapse before SVR12, when there are those of us who report Detected at EOT and even after, who wind up Undetected at that same SVR12 marker.   

The one Im really dreading the most is the SVR12 UND result that becomes Detected with viral load at the SVR24 test...  Thats going to be a killer, although the odds are minuscule of it ever happening.
« Last Edit: June 10, 2015, 02:54:09 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Grateful 52

  • Newbie
  • Posts: 2
1. 4wk  EOT VL status Undetected
2. Treatment duration 12 weeks
3. tx naive
4. Genotype (1a)
5. F1-F4 fibrosis status unknown, ultrasound only- showed nothing
6. Initial VL -1 mil in mid 2014, likely infected 1972.
This is my first post, but Ive been reading your posts for the past year, since diagnosis.  Viral load at 4 and 8 weeks during treatment was detected <12, so results 4 wk after EOT was quite a relief !   Liver enzymes are all normal now, platelets a little low.  Feeling more energy than I've had in years!  Many many thanks to all of your informative posts, made the journey so much smoother...from insurance coverage, through side effects, interpreting lab results to post EOT. 
Will post 12 week EOT when known.  Best wishes to all!

Offline Bob V

  • Member
  • Posts: 231
Grateful52

Good luck.
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline lporterrn

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  • Posts: 1,984
  • LucindaPorterRN
    • LucindaPorterRN
Dear John,
I am sorry to hear this. I want to say something encouraging, but not empty, when I know that healing from this news is a process that takes time. I've been through it, as have others, and feel free to lean on us.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline Mike

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  • Member
  • Posts: 999
Hi John,

I'm sorry to hear this, and, having failed treatment before, I know what a bummer this can be. Please don't be to hard on yourself.

Hang in there. There a lots of new things on the horizon.

Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline jberlin

  • Global Moderator
  • Member
  • Posts: 306
  • Contracted Hep C in 76, treated 2004 & 2012, cured
John,

Let me echo the words of hope others have offered you.  I too relapsed, and it was devastating. Unfortunately 90% success rates still means that 10% experience failure.  As others have said there are more and more options and improved treatments nearly every year, so chin up and you will beat this awful virus.

Best wishes,
jack

Offline Lynn K

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  • Member
  • Posts: 4,526
  • Get tested, get treated, get cured, fight Hep c!
Hi John

So sorry to see this news

I also failed Sovaldi and Olysio last year and was crushed by the news.

Hang in there new meds are coming that look like even better results.

But for now I am sending a warm hug out to you hang in there

Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Junkyard

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  • Posts: 24
These liver function values fluctuate..  The difference in the numbers you're quoting is tiny; I'd view it as noise in the system.

Offline Junkyard

  • Member
  • Posts: 24
Thanks for the words. I have been through the relapse brefore and it really does make you feel very helpless. What we have to go through is bad enough but then to get the bad news is really heart felt.
I got my news last time the night of my granddaughters graduation from high school.
Hoping that day never comes again.
Good luck to all

Offline Lynn K

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  • Member
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  • Get tested, get treated, get cured, fight Hep c!
I had the same a slight increase at 4 weeks post but I am trying not to be concerned as my ALT/AST are still in normal range and yours look like they are also.

When I relapsed last year it was my ALT that went above normal.

My EOT Sov/Oly last year were ALT 29 AST 25
and my results on relapse 12 weeks later ALT 56 AST 45

Did you have a 4 week viral load test and have those results come in yet?

Good luck
« Last Edit: June 10, 2015, 08:04:46 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline kate0b1

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  • Posts: 293
update for labs, 12 post is back and UND, i will ask my family doc for 24 wk labs just so i can feed my OCD, but for now done, done and done.

1. 12 wk EOT VL status - Undetected
2. Treatment duration - 12 weeds
3. tx naive or experienced - experienced
4. Genotype (1a or 1b) - 1a
5. F1-F4 fibrosis status unknown
6. Initial VL unknown from relapse

stay well everyone
kate

Offline Bob V

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  • Posts: 231
YAY Kate!!!!!!!

I'm getting 24wk labs too, my doc only wanted 24 but I requested 12wk too...I wasn't waiting that long to find out.
« Last Edit: June 11, 2015, 04:15:50 pm by Bob V »
Male 64
Dx hep non AB 1972, Hep C 1991
GT 1A
VL 3.7m (pre tx)
Liver B 1992, unremarkable
Liver ultrasound 2014, normal
Treatment Interferon 90's x2 failed
Started Harvoni 12/08/2014 (12wks)
Finished Harvoni  3/1/15
5wk lab detected <15
8wk lab UND
EOT lab UND!
12wk post lab UND!
24wk post lab UND!
58wk post lab UND!

Offline Mike

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  • Member
  • Posts: 999
Congrats, Kate!

Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline Katie

  • Member
  • Posts: 784
I put on my dancing shoes and here's your HAPPY DANCE KATE!  You just made my day.  Celebrate your new life and stay in touch!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Thanks to everyone for the kind thoughts. It's very difficult to process, almost as if I'm grieving. Will get through this. Just really believed that I was finally cured, only  to have the bottom fall out. Need a little time and then I will come up with a new game plan. Everything in my life was finally going good and then blasted with the news I relapsed. Really tough blow. So happy for everyone that made it. Thank you for caring.

John
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline Katie

  • Member
  • Posts: 784
John, You are grieving and that's OK.  You will move on, you've given your liver a much needed rest, and hope is not gone for a cure in the near future.  We are here for you.

{{{HUGS}}}

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

 


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