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Author Topic: 1-shot HCV cure on horizon  (Read 10798 times)

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Offline terih

  • Member
  • Posts: 74
Re: 1-shot HCV cure on horizon
« Reply #1 on: April 29, 2015, 08:09:08 pm »
Oh this is so exciting, I have a Harvoni relapse appointment at the Texas Liver Institute in 2 weeks! Maybe I'll get a chance at this 1 shot dealio!  :)





64 yrs. on this fine planet!
diagnosed 1993
Stage 1 cirrhosis
Genotype 1a
12 wks. Harvoni  Relapse late Feb. 2015
Currently treating with Solvaldi/Olysio
The light at the end of the tunnel, is often not a train!

Offline seekir

  • Member
  • Posts: 32
    • Mikey's Island
Re: 1-shot HCV cure on horizon
« Reply #2 on: April 29, 2015, 09:47:20 pm »
Guess there may be good reasons for some of us to be patient and wait a bit longer. I assume they're having some positive results, they seem to be keeping their cards pretty close to their chests.
61 yo male
Genotype 1a, treatment naive till 8/6/15 when Harvoni treatment was provided through Gilead's Support Path after health insurer (HMSA) denied Harvoni treatment and appeal due to moderate F1/F2 liver status. Sides very mild, virus "undetectable" at 28 days.

Offline spitzbar

  • Member
  • Posts: 25
Re: 1-shot HCV cure on horizon
« Reply #3 on: April 30, 2015, 07:25:06 pm »


.....it's always a pleasure to see the news was carefully read.   And most certainly explore your opportunity there in Texas, we're sure you'll be considered a valid candidate.   

Offline pappy

  • Member
  • Posts: 22
Re: 1-shot HCV cure on horizon
« Reply #4 on: May 09, 2015, 03:47:00 pm »
Very interesting thank you for this information .

Offline GLCII

  • Member
  • Posts: 127
Re: 1-shot HCV cure on horizon
« Reply #5 on: July 16, 2015, 05:35:51 pm »
That was deffinitly an interesting read.
Pre Tx (VL 12043488) ALT 52/ AST 39
Harvoni Start Date 03/12
2 Week in Tx Results HCV RNA Detected, less than 15 IU/mL. ALT 19 / AST 19
4 Weeks in Tx Results HCV RNA Not detected. ALT 21 / AST 18
12 Week in Tx Results HCV RNA Not detected. ALT 17 / AST 19
--------------------------------------------------------------
Post 12 Week EOT Tx ALT 19/ AST 19 (Undetected)
Post 24 Week EOT Tx ALT 19/ AST 15 (Undetected)

Offline MelHu

  • Member
  • Posts: 33
Re: 1-shot HCV cure on horizon
« Reply #6 on: September 14, 2015, 07:47:44 pm »
Definitely interesting.  I am genotype 2b and F3 liver status on last 5 days of Sovaldi/RIBA. I was a little down-hearted until now because at my 6 week testing there was still a VL of 49IU/ml and at 8th week 40IU/ml. So I was figuring that I might be a non- responder seeing that most anyone with success has a < VL at 4 weeks.  But this could be an alternate treatment for this silent disease. Probably got it thru blood transfusion at my son's birth in 1979. Just diagnosed in March 2015. Devastating news but so much progress and greatness for those who do achieve SVR. Here's hoping for the best for all on this crazy, scary and happy trip to eradicating this awful disease.
Mel
Genotype 2b
Probably contacted in 1979
3/2015 VL 3,250,000
   Alt 70.    Ast 31 U/L
   F3 liver status
Sovaldi/ribavirin
12week duration 6/28/15-9/19/15
TX naive
7/25/15 VL 49 IU/ml
   Alt 11
8/22/15 VL 40 IU/ml detected. Alt 9
9/19/15 VL <20 IU/ml detected Alt 12
10/21/15 VL <20 IU/ml detected not-quantifiable
11/24/15  8 week EOT UNDETECTED
3/19/16  6 month EOT Undetected  SVR
I am truly blessed!!!
Finally!  I am truly thankful to be free of it!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: 1-shot HCV cure on horizon
« Reply #7 on: September 19, 2015, 04:07:14 pm »
What irony if this works.  I mean how wonderful, but also how very ironic.  When I think of all the lead up to this time.  Folks infected for 20 to 50 years... the transplants... the many years of peg and ribo... the army of liver cirrhotics... the long path of the new drugs to market... and politics to meet the high price.  I never imagined over the decades that a one dose drug might do the trick, but it was one of my three wishes to a gini.

Lovely to know that the battle continues for those in the wings or the ones that have had relapses.  One things for sure, it might drive down the price of Harvoni.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: 1-shot HCV cure on horizon
« Reply #8 on: September 19, 2015, 05:00:24 pm »
Earlier this week, I attended a program by four local hepatologists. The one who spoke about what's coming down the pike mentioned a single-shot cure; he estimated it would be publicly available around 2025. He also mentioned treatments arriving in 2016 (a single-tablet therapy for genotypes 1, 4, 5, and 6 that would be safe for those with end-stage kidney disease; also, a possibly better treatment for genotype 3), 2017 (a therapy that would take only 6-8 weeks), and 2018 (one or more treatments that would take only 4 weeks).
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

 


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