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Author Topic: Treatment naive but still detectable after 4 weeks  (Read 13311 times)

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Offline Bchu

  • Newbie
  • Posts: 1
Treatment naive but still detectable after 4 weeks
« on: October 31, 2015, 09:20:43 pm »
Hello,
I'm really wondering what it means that I am still detectable after 4 weeks on harvoni,
<15 at least it's lower than the  6 million that it was a month ago. Since I am only on 8 weeks of treatment are my chances of being cured decreased???
Should I ask my doctor to try and keep my me on harvoni for four more weeks.
I'm really confused, anyone with experience in something like this ???
Had hep c since 2008, never treated, before treatment VL 6 mil,
At four weeks <15 detectable, 23 25 ast alt.
Thanks everyone .


Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment naive but still detectable after 4 weeks
« Reply #1 on: October 31, 2015, 09:32:23 pm »
Hi and welcome to the forum,

It doesn't mean anything that you are still detected at 4 weeks the only test that matter is the 12 weeks after treatment has ended. There is no correlation with early not detected and eventual SVR with this new generation of meds.

There have even been a few here who were weakly detected at the end of treatment but went on to achieve SVR 12

If you have any questions about your treatment your doctor is your best source of information

good luck on treatment
Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline moz1959mel

  • Member
  • Posts: 11
  • Who's house? Runs House!
Re: Treatment naive but still detectable after 4 weeks
« Reply #2 on: October 31, 2015, 10:46:53 pm »
I really hate to sound stupid but what does "SVR12" mean? I keep seeing it everyone (just joined 2 days ago).
Thanks and be blessed  ;D
Infected: 1998
Diagnosed: 2007
Treatment: Naive

Fibroscan: F0/F1 10/01/2015
GT: 2
VL: 8,100,000
AST: 19
ALT: 27

Began Sovaldi (400 mgs) + ribavirin (1200 mgs) on 10/28/15
Bloodwork - Virus Undetected 11/28/15

Offline Philadelphia

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  • It only looks like I know what I'm doing
Re: Treatment naive but still detectable after 4 weeks
« Reply #3 on: October 31, 2015, 11:07:07 pm »
SVR12 means sustained virological response at 12 weeks after the end of treatment. If after 12 weeks post treatment there is no virus, i.e. A sustained response, you are considered cured.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment naive but still detectable after 4 weeks
« Reply #4 on: October 31, 2015, 11:08:47 pm »
SVR= sustained viral response meaning the after a given time post treatment you have a sustained response against the virus

SVR 4 means not detected 4 weeks after treatment has ended SVR 12 is 12 weeks after treatment has ended still being not detected which by most doctors means cured SVR 24 = 24 weeks post treatment which the remaining medical professionals want to see before they will call you cures

And welcome to the forum moz!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Treatment naive but still detectable after 4 weeks
« Reply #5 on: November 01, 2015, 01:06:44 am »
 Hey Moz,  The only stupid question is the one that is never asked. Keep on asking . The forums are a wonderful place to get informed and educated in all sorts of areas where knowledge is lacking or needs updating!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline moz1959mel

  • Member
  • Posts: 11
  • Who's house? Runs House!
Re: Treatment naive but still detectable after 4 weeks
« Reply #6 on: November 01, 2015, 08:49:37 am »
Thanks so much you guys  ;D
Infected: 1998
Diagnosed: 2007
Treatment: Naive

Fibroscan: F0/F1 10/01/2015
GT: 2
VL: 8,100,000
AST: 19
ALT: 27

Began Sovaldi (400 mgs) + ribavirin (1200 mgs) on 10/28/15
Bloodwork - Virus Undetected 11/28/15

Offline JAF

  • Member
  • Posts: 49
Re: Treatment naive but still detectable after 4 weeks
« Reply #7 on: November 01, 2015, 10:34:32 am »
Bchu welcome!  With a 6mill VL pre tx it's not a bad sign to have some VL still detectable. I haven't had my 4 wk labs yet but I am already preparing myself that there may be some detectable VL still hiding somewhere. As long as it's minimal I can accept it. My pre tx VL was slightly under 4.5 mill. Like mentioned above. Svr12 is our focus. Good luck
Female; 56; New York
Infected: mid 70's
Diagnosed: 2000
Treatment naive
Began Sovaldi + riba (1200 mgs) on 10/15/15
GT 2b
PRE-TREATMENT:
VL: 2,412,570
AST: 50
ALT:  52
Fibrospect index: 42

4 wk labs done 11-14. Waiting for results

Offline Else

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  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Treatment naive but still detectable after 4 weeks
« Reply #8 on: November 01, 2015, 11:41:18 am »
Welcome bchu,

Just think of it - from 6 million to less than 15 in four weeks!  It sounds like you're doing great.  The viral load test you took doesn't measure amounts under 15, hence the generic "<15".  So for all you know that number could be 2!

A wonderful start.  Congratulations!

Hi Moz.  The board is full of HCV shorthand: tx, sxs, SVR, etc.  So if you need the 411 on any FAQ, ask away.  ;)
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Treatment naive but still detectable after 4 weeks
« Reply #9 on: November 01, 2015, 08:11:27 pm »
About HCV acronyms: In January, moderator Lynn K. posted a list of them along with their meanings. Here is the link to her post:
http://forums.hepmag.com/index.php?topic=1653.msg12340#msg12340
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

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  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment naive but still detectable after 4 weeks
« Reply #10 on: November 01, 2015, 08:12:38 pm »
Thanks for finding that Gnatty

I knew I left that somewhere lol

I see that SVR is missing from the list but we sure use it lot now!

OK edit SVR is on the list
« Last Edit: November 02, 2015, 12:41:59 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline JAF

  • Member
  • Posts: 49
Re: Treatment naive but still detectable after 4 weeks
« Reply #11 on: November 01, 2015, 08:45:26 pm »
There is just so much info on here and if you check in every day you'll learn all the acronyms very fast. I joined on day 6 of treatment and had to look up what SVR and sxs meant. Tomorrow is day 19 and I've learned so much already. We can't pick up the phone and call the doctor with every thought or question but there's always someone here to offer advice. Thanks guys!
Female; 56; New York
Infected: mid 70's
Diagnosed: 2000
Treatment naive
Began Sovaldi + riba (1200 mgs) on 10/15/15
GT 2b
PRE-TREATMENT:
VL: 2,412,570
AST: 50
ALT:  52
Fibrospect index: 42

4 wk labs done 11-14. Waiting for results

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Treatment naive but still detectable after 4 weeks
« Reply #12 on: November 01, 2015, 11:27:42 pm »
Great list!  So I had a RVR.  Hey, that's kind of a BFD.  ;)

 ;D
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment naive but still detectable after 4 weeks
« Reply #13 on: November 02, 2015, 12:45:17 am »
Today with the new DAA's RVR is not as much a BFD as it was in the past with P/R Tx. Now we look for SVR after EOT to determine if Tx was a success and the Dx can change to UND HCV RNA

LOL
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Treatment naive but still detectable after 4 weeks
« Reply #14 on: November 02, 2015, 02:43:37 am »
Thanks, Else, for giving me a chance to prove that I don't know much. Not finding BFD on Lynn's list of Hep acronyms, I Googled this new-to-me TLA. I take it you DON'T mean:
- Boston Fire Department
- Bidirectional Forwarding Direction
- a streamlined, fun and affordable software instrument for acoustic drums
- San Diego's savory deli Big Front Door
- Behindertenfahrdienst (German: Transport of Disabled)
- Budgerigar Fledgling Disease
- Breakfast for Dinner
or a host of other things (Acronym Finder lists 77 possible meanings).

BTW, I think I've figured out which one you DO mean  :o

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Treatment naive but still detectable after 4 weeks
« Reply #15 on: November 02, 2015, 12:20:16 pm »
I feel ya, Gnatty.  I used SNAFU for decades before I even knew that it was an acronym.  :)  Now that I think about it, SNAFU should definitely be on the list as part and parcel of your average medication approval experience.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Treatment naive but still detectable after 4 weeks
« Reply #16 on: November 03, 2015, 08:44:43 am »
 I don't guess We need to get into FUBAR, BOHICA, or FYJIMO as they might not be appropriate for sensitive ears! LOL.
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: Treatment naive but still detectable after 4 weeks
« Reply #17 on: November 03, 2015, 10:36:03 am »
Lynnk could you repost that acronym thread ASAP for newbies and even oldbies?
Get it to the top of the heap or maybe under a different title?
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline Shenny

  • Member
  • Posts: 4
Re: Treatment naive but still detectable after 4 weeks
« Reply #18 on: November 03, 2015, 11:23:26 am »
Hi all. First time on the site; long time HCV.  Infected 1970; Diagnosed 1994. Viral load 7M+ F4-cirrhosis. Treatment naive because I heard the side effects of Ribavarin/Interferon were too debilitating.  I was willing to take my chances and wait till something better came along.

Then along came Harvoni.  I started 1st dose of a 12 week course on October 2, 2015.  The side effects so far are minimal. I'm more tired than usual, but I can deal with that.  I took my 1st blood test on October 27th and tomorrow I have my first follow up with the doctor after starting treatment.  Needless to say I'm very anxious about this appointment.  I will let you guys know the results.

I'm so fortunate. I was approved for the treatment within a month of taking all the required scans and blood work.  My $3k  monthly co-payment was absorbed by a foundation. I wish everyone good luck with this treatment.  I hear it is miraculous.


Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Treatment naive but still detectable after 4 weeks
« Reply #19 on: November 03, 2015, 11:37:29 am »
Welcome, Shenny. You're in good company. I, too, got HCV in the early 70's but took my chances waiting, even though it was hard on my liver (see the pre-treatment stats below). When my patient portal sent an email indicating there were results from my 4-week lab tests, my hand actually shook when I went to click on the link. It turned out that Harvoni is indeed miraculous. I predict you'll be on cloud 9 tomorrow, or at least cloud 7 if the HCV viral load is slightly detected rather than undetected. Either way, your odds for a cure are terrific. -Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Shenny

  • Member
  • Posts: 4
Re: Treatment naive but still detectable after 4 weeks
« Reply #20 on: November 03, 2015, 01:24:21 pm »
Gnatty-

Can you please tell me what  FibroScan F4 kPa 19.5
05/15/15 FibroSure F2 Necroinflam.act.grade A3 means?  I am F4 as well.  I have asked my doc how bad is my cirrhosis, but he keeps giving me an evasive answer.  I am trying to find out the amount of liver damage I've sustained from this disease.

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Treatment naive but still detectable after 4 weeks
« Reply #21 on: November 03, 2015, 02:50:30 pm »
The FibroScan kPa is a measurement which is explained in this chart: http://hepatitiscnewdrugresearch.com/fibroscan-results-the-scoring-card.html
   Necroinflam.act.grade A3 is "Severe activity" (A3 is the worst; A0=No Activity, A1=Minimal activity, and A2=Moderate activity). Necroinflam. stands for necrosis + inflammation.
   There are various ways of measuring whether there's fibrosis and, if so, how much. Biopsy is one way, FibroScan is another, and various blood tests such as the FibroSure are yet another way. They each come up with a fibrosis score, with stage F0 meaning no fibrosis and stage F4 meaning cirrhosis. No test is foolproof (even a biopsy sees just a bit of the total picture), which is why my FibroScan and FibroSure results, taken just two days apart, came to very different conclusions. It is also why your doc is reluctant to say just how bad your cirrhosis is.
   One piece of good news is that a few recent well-conducted studies indicate that, once a cirrhotic is cured of hepatitis, the amount of fibrosis can decrease. Until very recently, it was thought that cirrhosis couldn't be reversed, but these recent studies indicate it is sometimes possible to improve enough to go from F4 to F3. A lot of us on these forums are looking forward to seeing if that will be true for us, and we are keeping our eyes out for more such studies.

HTH,
Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment naive but still detectable after 4 weeks
« Reply #22 on: November 04, 2015, 01:00:35 am »
Hi Shenny and welcome

Extent of liver damage once diagnosed with cirrhosis is basically based on if you are having symptoms of cirrhosis or not.

If you do not have symptoms you would be considered compensated if you begin to experience symptoms of cirrhosis you would be considered to be decompensated,

What is decompensated cirrhosis?

Cirrhosis

If you experience any of the serious problems described below, your disease has progressed from compensated cirrhosis to decompensated cirrhosis. You are then at risk of dying from life-threatening complications of liver disease, unless your sick liver can be replaced with a healthy liver (liver transplant).

    Bleeding varices (internal bleeding)
    Ascites (fluid in the belly)
    Encephalopathy (confusion)
    Jaundice (yellowing of eyes and skin)

http://www.hepatitis.va.gov/patient/complications/cirrhosis/decompensated.asp

I was diagnosed with cirrhosis 8 years ago and even though I had developed esophageal varicies that needed to be banded (enlarged blood vessels similar to varicose veins in your swallowing tube) and have some edema I am still considered compensated.

Another way that cirrhosis is staged for severity of liver disease is a scoring systems based on some of your blood test results

There is the MELD score (Model for End-Stage Liver Disease) which uses your INR, bilirubin, and creatinine scores to determine how high you would be on the liver transplant list. The score goes from 6 to 40 and at most transplant centers your score would have to be at least 15 to be on the transplant list.

For reference my MELD score is 8

http://www.mayoclinic.org/medical-professionals/model-end-stage-liver-disease/meld-model
Here is a Wikipedia article about the MELD score

https://en.wikipedia.org/wiki/Model_for_End-Stage_Liver_Disease

The other scoring system commonly used is the Child-Turcotte-Pugh score

It uses your PT (prothrombin Time or INR) results along with your albumin and bilirubin test results as well as whether you have any ascities or hepatic encephalopathy

Here is a calculator:
http://www.hepatitis.va.gov/provider/tools/child-pugh-calculator.asp

And a Wikipedia article
https://en.wikipedia.org/wiki/Child-Pugh_score

I am considered to be a Child "A" score.


The fibroscan only confirms cirrhosis the extent of damage is evidenced by symptoms.

One common early symptom is a low platelet count minimum normal is 150 mine is about 80 to 90 I have seen some with numbers as low as 50 or lower.

What happens is that due to the scaring of the liver it is difficult for blood to flow through the main vein in the liver called the portal vein. This causes high blood pressure in that vein aka portal hypertension. This can cause esophageal varicies as well as cause the spleen to enlarge and begin to sequester platelets which is what causes the low platelet count.

The good news is that with cure of hep c our livers won't get any worse and may begin to improve with time. with cure we can with care and kindness to our livers expect to live a normal life span.

I hope this helps somewhat let me know if you have any more questions and I will try my best to answer them.

Good luck on treatment

Lynn
« Last Edit: November 04, 2015, 01:02:15 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Treatment naive but still detectable after 4 weeks
« Reply #23 on: November 04, 2015, 06:56:15 am »
I'm confused Else,
                         Aren't SNAFU and SX the same thing?
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Treatment naive but still detectable after 4 weeks
« Reply #24 on: November 04, 2015, 10:39:20 am »
LOL Not always, Bill.  It was a happy surprise to me that there can be positive Sx.  It's a roll of the dice.

And thank you to Tommy for expanding my acronym lexicon.   ;D ;D ;D
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Treatment naive but still detectable after 4 weeks
« Reply #25 on: November 04, 2015, 03:10:34 pm »
More like a crap shoot, but I digress!!! :-\ :-X :-[
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Treatment naive but still detectable after 4 weeks
« Reply #26 on: November 04, 2015, 04:47:55 pm »
How ya feelin' Tommy?   Still hankering to get out to your High Lonesome for some quiet time?
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Treatment naive but still detectable after 4 weeks
« Reply #27 on: November 04, 2015, 10:18:56 pm »
 Hey Else, Feeling kinda funky the last few days. No energy or appetite. Having some lower G.I. issues again. Can't seem to get by it. Doc says oh well, as long as no high fevers or dehydration problems keep on keepin on.
  Trying to scrape up some extra scratch to make it out to Gods' Country for a little one on one with the Big Guy!
  BTW, just noticed the avatar :o :-\ :P ::) ??? ;) No more disenfranchised semi angry rapper left in You? :)LOL.
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

 


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