post-AbbVie

[Nobody Special]

Did anyone here go thru Abb-Vie treatment?

I enrolled in clinical trial in 2013.
This was my protocol: for 12 weeks.
dose twice a day.  in morning, take all five:
ABT-450/r, a protease inhibitor
        taken with ritonavir;
the NS5A inhibitor ABT-267;
the non-nucleoside polymerase inhibitor ABT-333;
and ribavirin ( as placebo )
in evening, just ritonavir & ribavirin

Immeasurably good news: it was successful, and I hear no one has relapsed.

The reason I ask:

I developed acid reflux during the trial.
At the time, I was prescribed Omeprazole,
(a PPD), which was effective.  A while after the trial,
it was no longer effective.  General Practitioner
prescribed Famatdine, which didn't work.  Prilosec
was effective while I took it, but box says don't take
for four months after.

Actually, I've developed a suite of symptoms which may or may not be related to the acid reflux :

After 8 months, the dizziness and ravenous hunger have subsided; remaining still are constipation, the acid reflux, heartburn, and nausea, to varying degrees. The latter sometimes precludes ability to work until it goes away. I also awaken with stomach pain, usually one or both sides lateral to nave, sometimes under sternum.
Still have (for me) errratic weight swings (6 lbs).

I've seen an endocrinologist, 2 gastroenterologists, my hepatologist, and my GP, and all I've found out ( via a endoscopy ) is that I've developed low-grade esophagitis, and beginning-stage ulcer near duodenum.

As I flail around in the dark, for diagnosing all my symptoms, and treating them, I'm going back to the first symptom -- acid reflux ( GERD ) which manifested during the clinical trial -- and presenting this to the forum in case anyone has had any similar situation.   Thank you.

Breathing in, I heal myself. 
Breathing out, I heal others. 
May all beings be well.

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[Lynn K]

You can take prilosec for longer per doctors orders from what I understand that is the OTC instructions. If you have chronic acid reflux/GERD that needs to be addressed by your gastro they are the experts.

I have that issue but for me it is from a hiatial hernia. I used to smoke and had a terrible cough. Sometimes I felt like I was going to cough myself inside out which is where I assume I developed the hiatial hernia.

Personally I think the clinical trial and your acid reflux are unrelated just occurring at the same time. Being ill can cause stress which can lead to stomach issues as well.

I hope they can find you help to feel better soon

Good luck
Lynn

[Philadelphia]

I did 24 weeks with ribavirin but didn't have any of those things you mention either before or during treatment. Does your doctor think they might be related to the ulcer?

Sorry, I'm not much use.