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Author Topic: Dose Timing?  (Read 5335 times)

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Offline Steve76

  • Member
  • Posts: 26
Dose Timing?
« on: January 23, 2016, 09:02:47 am »
I am a bit worried about the way I have been taking my Harvoni pills after reading about RAVS. 

I haven't missed any doses,  I took my 1st pill in the evening around 5:30 PM(Nurse wanted me take the first pill it in front of here).
 I realized this time would not work for me so I took the 2nd pill at 9:00 AM the next day but it was only 15.5 hours later not realizing this was two close together(I guess there is supposed to be at least an 18 hour window between pills).   Obviously I did not overdose, but I am worried about the initial doses being close together and the possible effect on the virus afterwords going from more of the harvoni in my system initially to less taking it at 9:00 am every day.

Also, there has been a couple of times on the weekend I took the pill a couple of hours later(slept later-probably twice). 

I was reading about relapses and started freaking out,  I have some OCD issues as well so worry is part of my makeup unfortunately.

I have been spot on about dosing times since then though.

Kind of freaking out I guess I should have been more aware of this, any experience with this or insight would be appreciated.


Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Dose Timing?
« Reply #1 on: January 23, 2016, 12:00:26 pm »
Hi, Steve -- you'll be fine. The CNP who supervised my treatment told me the day before I started that if I accidentally took 2 pills on the same day, that wouldn't be a problem, since phase 1 clinical trials have high doses, then later phases figure out the lowest dose that'll work. I've been reading these forums for about a year now, and I remember that a particular person accidentally swallowed 2 Harvoni in the same day early in his treatment, yet he got cured (defined as he reached SVR12: no virus detected 12 weeks after the end of treatment). Also, lots of people had to change their time, which they generally did by adjusting 2 hours at a time, so being a couple of hours late should also not be a problem.

9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85


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