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Author Topic: High ALT and AST after 1 month EOT  (Read 16471 times)

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Offline msu

  • Member
  • Posts: 12
High ALT and AST after 1 month EOT
« on: March 03, 2016, 12:02:32 am »
Dear All

Its one month now I finished my SOV+RIBA 24 weeks treatment for GT-3a.

I went for blood test and my ALT 57 (Max range-41) and AST 41 (max range-40) are elevated.

Is it a concern that HCV may have returned? Thinking of this makes me really feel sad.

Nonetheless my doctor does not want to comment and has requested for a viral load test next week.


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MSU
GT3A
Sovaldi+Riba for 24 Weeks
VL before treatment 2.9 million
Treatment started 8.8.15

Offline Lynn K

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  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: High ALT and AST after 1 month EOT
« Reply #1 on: March 03, 2016, 03:26:14 am »
There are different things that can raise ALT and AST the only way to know what is going on is go have a viral load test.

Wishing you good luck
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline msu

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  • Posts: 12
Re: High ALT and AST after 1 month EOT
« Reply #2 on: March 03, 2016, 04:30:30 am »
Thanks Lynn

I am keeping my fingers crossed, gave the blood sample for viral load today and will receive the report within 10 days.
Logged
MSU
GT3A
Sovaldi+Riba for 24 Weeks
VL before treatment 2.9 million
Treatment started 8.8.15

Offline BillT

  • Member
  • Posts: 573
Re: High ALT and AST after 1 month EOT
« Reply #3 on: March 03, 2016, 10:23:29 am »
Hi MSU,
          I found this and thought I would pass it on.It's something to consider depending on how your tests come out.This one is actively recruiting.



https://clinicaltrials.gov/ct2/show/NCT02607735?term=gilead&rank=50
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #4 on: March 03, 2016, 01:41:55 pm »
Thank you for the link MSU. I got my viral load back and am udectected but i did not get a response about the rise in my alt. I rather jump right back on treatment now since i just stopped if i need to so answers would really help me.
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Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: High ALT and AST after 1 month EOT
« Reply #5 on: March 03, 2016, 10:02:30 pm »
Hi Ms and welcome

You might want to read this article but basically elevated liver enzymes could be caused by different things. How long after treatment was this viral load taken?

What do high (elevated) liver tests (AST and ALT) mean?

http://www.medicinenet.com/liver_blood_tests/page4.htm

"AST (SGOT) and ALT (SGPT) are reasonably sensitive indicators of liver damage or injury from different types of diseases or conditions. However, it must be emphasized that higher-than-normal levels of these liver enzymes should not be automatically equated with liver disease. They may mean liver problems or they may not."

Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #6 on: March 03, 2016, 10:21:57 pm »
Thank you Lynn for the additional info. I have to stay positive end the end of this month and May. Reading things on this forum helps a lot.  :)
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Offline CureSeeker

  • Member
  • Posts: 121
  • Virus Free! Happy Dance Time!
Re: High ALT and AST after 1 month EOT
« Reply #7 on: March 05, 2016, 04:04:15 pm »
Our genotype (3a) is not the easiest to treat, but you do need to keep positive about your treatment working.  The mind is a very powerful tool, and can overcome insurmountable situations.

I am paranoid about relapse, but I had a very good in-my-face reason to be paranoid about it.  Every time my bloods come back undetected I feel less and less paranoid, and more and more like a vanquisher of dragons, lol.  *puffs out chest and flexes muscles*

In my experience, and we are all different, treatment messed me up with severe anemia during treatment.  RA runs in my family, and that seemed to also have become a bit aggravated, but nothing debilitating, and shortly after treatment stopped I had a small rash on my belly which disappeared within a few days.

I'm still waiting for bloods to get perfectly back to normal, but they are headed that way.  *thunbs up*

Anyway, the point of all that being, you just came off of taking some pretty powerful drugs religiously for 6 months, then you abruptly stopped.  We can all expect our labs and bodies to be going through adjustments.

If you were an avid coffee-drinker for 6 months religiously, then abruptly stopped, it would not be hard to imagine feeling messed up until your body adjusted to no longer having the caffeine multiple times a day, as an example.  If something as mild as caffeine can have us all messed up, its not hard to imagine something like chemotherapy having us all messed up for a while.

I hope your AST/ALT gets back to normal on your next labs and relieves your mind of any further worry regarding relapse or cancer. 

Until then, live for today, and worry about being happy.  You can trip on the sidewalk or slip on a banana peel, get hit by a bus or train, or any number of ways we can die right now, and then all the time we spent worrying about relapse etc would just be time and energy we wasted.

Be happy!  Best wishes! :)








Logged
Once you eliminate the impossible, whatever remains, no matter how improbable, must be the truth.

~ Arthur Conan Doyle


Genotype 3a, F 0-1
Sovaldi & Ribavirin x 24 weeks

2/23/16 - UNDETECTED!  SVR12 achieved.  :D
6/21/17 - UNDETECTED!  1.5 years post treatment.
July 2018 - UNDETECTED!

Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #8 on: March 05, 2016, 05:47:21 pm »
 :) very true!
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Offline msu

  • Member
  • Posts: 12
Re: High ALT and AST after 1 month EOT
« Reply #9 on: March 05, 2016, 11:35:40 pm »
@MS Brat

Happy to hear about your UND thats the 2nd best news , 1st one obviously the SVR  :).

I will also get my results of Viral Load this week and i am also trying to think positive. Lets C  :D

Also thanks Lynn, Bill and CureSeeker for sharing the useful info.

Cheers
Logged
MSU
GT3A
Sovaldi+Riba for 24 Weeks
VL before treatment 2.9 million
Treatment started 8.8.15

Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #10 on: March 06, 2016, 02:17:34 am »
Makes it easier to have this to share everything through this journey. Best of luck. :)
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Offline msu

  • Member
  • Posts: 12
Re: High ALT and AST after 1 month EOT
« Reply #11 on: March 08, 2016, 04:39:13 am »
Hi All

Wanted to share the gud news...

Got my VL back UND  :) :) :)

Overjoyed and delighted and took a sigh of relief after getting the report.....

Asked doc about the high ALT n AST levels and he thinks that this might resulted from the workout i started after the EOT. He is now 99% sure that i will achieve SVR since 1 month result replicates the 3 months result EOT.

Cheers
Logged
MSU
GT3A
Sovaldi+Riba for 24 Weeks
VL before treatment 2.9 million
Treatment started 8.8.15

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: High ALT and AST after 1 month EOT
« Reply #12 on: March 08, 2016, 05:55:05 am »
Fantastic news congrats!
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: High ALT and AST after 1 month EOT
« Reply #13 on: March 08, 2016, 07:53:32 am »
Good news :)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #14 on: March 08, 2016, 12:39:33 pm »
Awesome news!
Logged

Offline MaryC

  • Member
  • Posts: 117
  • Life is not a sprint; it's a marathon.
Re: High ALT and AST after 1 month EOT
« Reply #15 on: March 15, 2016, 02:43:36 pm »
Quote from: msu on March 08, 2016, 04:39:13 am
Hi All

Wanted to share the gud news...

Got my VL back UND  :) :) :)

Overjoyed and delighted and took a sigh of relief after getting the report.....

Asked doc about the high ALT n AST levels and he thinks that this might resulted from the workout i started after the EOT. He is now 99% sure that i will achieve SVR since 1 month result replicates the 3 months result EOT.

Cheers
MSU,
I was sweating my 12 week post tx VL results also.  I was able to access my LFT's which were mildly elevated...specifically my AST which was 44!  I was certain that I relapsed.  It took several days (with a weekend filled with angst), but learned my VL 12 weeks post tx remains negative...Yippee!  In exploring what could cause my AST's to elevate (I don't have other risk factors such as alcohol or fatty liver disease), it was determined that this was caused by exercise - specifically marathon training!  I ran 17 miles on Sunday before my test on Wed and 7.5 miles on Tuesday the night before my blood test.  They believe the AST elevation was d/t muscle damage which happens with extreme exercise. 

Glad to hear you had good results in the end.  Good to hear from someone else with a similar experience with elevated LFT's not from relapse.

Mary
Logged
GT 3a
Dx'd 4/15 not known when contracted
Labs 7/15:
-VL 537,000
-AST 32
-ALT 41
-Fibrosis score 0.46 (F1-F2)
Started tx 9/17/2015 with Daklinza + Sovaldi
6/6/16: 24 week EOT SVR!  Cured!

Offline Mikoda

  • Member
  • Posts: 4
Re: High ALT and AST after 1 month EOT
« Reply #16 on: March 24, 2016, 10:17:43 am »
So glad I found this.  I'm now 5 weeks on Harvoni and prior to treatment ALT was 37, now 1212 and AST was 39, now it's 888.  Good news, virus showed not detected.  My doctor has no idea and said he'd never seen this before.  Anyone seen this drastic increase in enzymes after beginning treatment?
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Offline MsBrat58

  • Member
  • Posts: 26
Re: High ALT and AST after 1 month EOT
« Reply #17 on: April 03, 2016, 03:31:14 am »
I was on Abvie and just had my 1 month eot blood work and my liver readings were perfect and i remain undetected. One more test to go. :)
Be patient with temporary rises in ast and alt as mine it also. It did settle down. Hang in there everyone. :)
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