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Author Topic: Merck MK-3682 & 8408 Study  (Read 6207 times)

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Offline Onefluover

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Merck MK-3682 & 8408 Study
« on: July 06, 2016, 09:56:15 pm »
Was just notified (after applying almost a year ago) that I have been accepted -or chosen- to participate in a trial study.  :) It is non-random. :) :) it will begin next month (August). I'm not finding anything archived here on these two drugs. Does anyone know anything about them that I should know about? Below is a bit of info and links:

Clinicaltrials.gov link: https://clinicaltrials.gov/ct2/show/NCT02759315?term=MK-3682+and+MK-8408&rank=5   (please note there have been a few protocol amendments, so criteria may vary a little). Treatment duration will be 8 or 12 weeks.
 
This is a Phase 2 Merck study assessing the safety/effectiveness of MK-3682 and MK-8408 for 8, 12, and possibly 16 weeks of treatment. These drugs were previously studied in combination with a third drug, and now they are determining if the double combo is as effective as the triple. As far as drug class goes, the regimen would be similar to Epclusa (Sovaldi/Velpatasvir). MK-3682 is an NS5B polymerase inhibitor and MK-8408 is an NS5A replication complex inhibitor.
 
Prior studies with the triple drug combo had cure rates over 90% for genotype 3, so we are hoping to see similar cure rates with the double drug combination.
 
http://www.businesswire.com/news/home/20151116005459/en/Merck-Announces-Presentation-Results-Phase-2-Studies
51 M HAV/HBV Im., HCV-G3a
Fibrospect 2 <16 (F0/1) VL 4M
Expsd 1984-1992 (?) dx 1992
First tx attempt 2015
Liver 18.6 cm, relatively course & echogenic w/ diffuse hepatocellular process. 
Abnormal labs: ALT 163, AST 73, Chol 118, HDL Chol 30, IGA .05, Ferritin 648, Iron Bind Cap 296, Iron Sat 60%
Signs & symptoms: Freq. severe headache, very high BP, abdominal pain, distentia, joint pain, dbl vis., white nails, Schamberg's Dis., nausea, mild Jaundice, dark urine, non-hereditary Hemochromatosis.

 


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