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Author Topic: Zepatier and Solvaldi 8 weeks in....  (Read 7682 times)

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Offline Ron C in YYZ

  • Newbie
  • Posts: 2
Zepatier and Solvaldi 8 weeks in....
« on: September 06, 2016, 08:24:16 pm »
Eight weeks in on Zepatier and Solvaldi. Zero side effects.

AST 23
ALT 23
VL <15

Pre-treatment
Male 57

Geno type 3 treatment niave
Stage 4 a cirrhosis
VL >6,000,000

Looks like it's working, fingers crossed, 29 more days to go...
« Last Edit: September 07, 2016, 10:08:22 pm by Ron C in YYZ »

Offline Gaj

  • Member
  • Posts: 172
  • Optimist
Re: Zepatier and Solvaldi 8 weeks in....
« Reply #1 on: September 07, 2016, 08:35:20 pm »
Hi Ron,

Good to hear that you are handling that combination well without sides. I will be watching your progress with interest as it is a potential future retreatment option that I have been discussing with my doctors.

PS should your VL result read <15 without the 000 after it?
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline Ron C in YYZ

  • Newbie
  • Posts: 2
Re: Zepatier and Solvaldi 8 weeks in....
« Reply #2 on: September 07, 2016, 10:16:33 pm »
Hi Gaj
             Yes, you are correct. I have changed it. I will also post updates. A visit to my GI Dr yesterday was not good. Was there for consult on the upper endoscopy he performed 3weeks ago. Turns out that I have developed esophageal varicies due to the cirrhosis. So now I am taking 40 mg Nadolol daily. Where does this stop? Will keep the updates coming.

Offline AllShookUp

  • Member
  • Posts: 30
  • "itching like a man on a fuzzy tree" - Not anymore
Re: Zepatier and Solvaldi 8 weeks in....
« Reply #3 on: September 08, 2016, 12:31:22 am »
Ron. You might not need to take Nadolol.

My GI told me to take 40mg Nadolol. My liver specialist said he was wrong. I suggest that you  read the below discussion. which covers this subject -

 "Seasoned Treatment Veterans" which is located in the Advanced Liver Disease Main Forum.
Male - BabyBoomer
1995 - diagnosed HCV
2002 - Peg + Riba - quit after 5 weeks severe anemia
2015 Nov -start 12 weeks Harvoni +Riba + Procrit
Gen 1b - VL 1,500,000 -ALT93-AST143
Comp cirrhosis - enlarged spleen - platelets 35
Week 5 of Tx - HCV undetected - ALT/AST normal
End Week 12 of Tx - HCV UD - ALT/AST normal
Jan. 25, 2016 EOT
April 4, 2016 - SVR10 UD - ALT/AST normal
May 5, 2016 - SVR14 UD - ALT/AST normal
Aug 5, 2016 - SVR28 UD - ALT/AST normal

 


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