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Author Topic: Retreatment after DAA Failure: Symposium on Salvage Therapy: 2016  (Read 7376 times)

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Offline elias

  • Member
  • Posts: 285
This is a fairly detailed and up to date online symposium on salvage therapy after DAA failures:

CME Internet Symposium:
Based on:AASLD 2016 Expert Review

http://hosted.medipix.com/aasld2016/

Ribavirin, as part of re-treatment regimen in the past, will rarely be needed with these newer approaches. Unfortunately, some of the key drugs needed for several of those options are not yet approved.

I read here that Gilead's triple DAA protocol Sof/Vel/Vox is likely to be approved in a few months. They have announced application for FDA approval today. It's probably good that other options are in pipeline as well. In terms of cost.

Any thought on this?


PS: There are many more topics covered in this symposium than retreatment. That just happened to be the topic I was most focused  on. The panel are well-known experts in the field. So worth sitting through it all
« Last Edit: December 08, 2016, 09:57:23 pm by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: Retreatment after DAA Failure: Symposium on Salvage Therapy: 2016
« Reply #1 on: January 23, 2017, 11:46:10 pm »
Thanks Elias this is great information.
Are you done with your journey? I see January 17th as end of treatment for you. I completed in 2015. My mind is blown by all the options available now.
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline elias

  • Member
  • Posts: 285
Re: Retreatment after DAA Failure: Symposium on Salvage Therapy: 2016
« Reply #2 on: January 24, 2017, 12:20:35 am »
Youre very welcome, sapphire.

I completed my 12 weeks of Epclusa on January 13. I'll probably take EOT+4week viral load just to see how it's going. Then hold on for EOT+12.

===============

Yes , there are options now for ribavirin-free re-treatment awaiting approval. I do wonder about possible insurance hurdles though
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

 


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